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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Cell and Circuit Design for Single-Poly EPROM 显示文摘 | HOE D H K SCHULTZ K J SALAMA C A T HADAWAY R A KEMPF P | 1989 | IEEE Journal of Solid-state Circuits1989，24，4： | 1 |
| 3 | Interaction of conjuated dienoic dervatives of linoleic with β-carotence on cellular host defence显示文摘 | Michal J J Chew B P Schultz T D | 1992 | FASEBJ1992，6，： | 1 |
| 4 | Wood laminates glued by enzymatic oxidation of brown-rotted lignin显示文摘 | JIN L NICHOLAS D D SCHULTZ T P | 1991 | Holzforschung1991，，45： | 1 |
| 5 | Effect of delayed drying time on copper distribution in the annual rings of ACQ-treated southern yellow pine research stakes 显示文摘 | GAN L DARREL D N SCHULTZ T P | 2006 | Forest Products Journal2006，56，3： | 1 |
| 6 | An improved synthesis of 6, 8-dimethoxy- 3-methylisocoumarin, a fungal metabolite precursor 显示文摘 | KENDALL J K FISHER T H SCHULTZ H P | 1989 | J Org Chem1989，54，17： | 1 |
| 7 | Interaction of conjugated dienoic derivatives of linoleic acid with β-carotene on cellular host defense显示文摘 | Michal J J Chew B P Schultz T D | 1992 | FASEB J1992，6，： | 1 |
| 8 | Wood laminates glued by enzymatic oxidation of brown-rotted lignin显示文摘 | Jin L Nicholas D D Schultz T P | 1991 | Holzforschung1991，45，6： | 1 |
| 9 | Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid显示文摘 | Hansen T Holm P Schultz K | 2004 | Int J Pharm2004，287，12： | 1 |
| 10 | Erythromycin inhibits Pseudomonas aeruginosa-induced tumour necrosis factor-alpha production in human whole blood显示文摘 | Schultz MJ Speelman P Van der Poll T | | 0，，02： | 1 |
| 11 | Lifetime migration with education strata 显示文摘 | SCHULTZ T P | 1982 | Economic Development and Cultural Change1982，，30： | 1 |
| 12 | Responses of monkey dopamine neurons to reward and conditionel stimuli during suocessive steps of learning a delayed response task显示文摘 | Apicella P Ljungberg T | 1993 | J Neurosci1993，13，3： | 1 |
| 13 | Estimating crossing fibers:a tensor decomposition approach显示文摘 | Schultz T Seidel H P | 2008 | Visualization and Computer Graphics2008，14，6： | 1 |
| 14 | Vibrotactile detection thresholds for chest skin of amputees following targeted reinnervation surgery显示文摘 | Schultz A E Marasco P D Kuiken T A | | 0，，： | 1 |
| 15 | A novel QSAR approach for estimating toxicity of phenols 显示文摘 | Schultz T W Bearden A P Jaworska J S | 1995 | SAR and QSAR in Environmental Research1995，5，： | 1 |
| 16 | Triton induced hyperlipidaemia in rats as an animal model for screening hypolipideamic drugs 显示文摘 | Schurr P E Schultz J R Parkinson T M | 1972 | Lipids1972，7，1： | 1 |
| 17 | Multilingual spoken language processing显示文摘 | Fung P Schultz T | 2008 | IEEE Signal Processing Magazine2008，25，3： | 1 |
| 18 | Steam explosion of mixed hardwood chips,ricehulls,cornstalks,and sugar cane bagasse显示文摘 | SCHULTZ T P | 1984 | Journal of Agricultural and Food Chemistry1984，，32： | 1 |
| 19 | Development of environmentally-be- nign wood preservatives based on the combination of organic bio- cides with antioxidants and metal chelators 显示文摘 | Schultz T P Nicholas D D | 2002 | Phytochemistry2002，61，5： | 1 |
| 20 | Deletions in the third intracellular loop of the thyrotropin receptor显示文摘 | Winerow P Schoneberg T Schultz G | 1998 | J Biol Cherm1998，273，14： | 1 |
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