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2篇 您的检索式:作者名="Sebastian Palm"
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1Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook 2019Regenerative Biomaterials2019,6,2:4
2混凝土路面砖通过“应力测试”显示文摘高浓度除冰剂.甚至在没有冰冻作用情况下.所带来的碱土金属氯化物也会对混凝土产生持续性损伤。位于德国杜塞尔多夫市的水泥工业研究院,针对各种类型除冰剂对混凝土路面砖的影响进行了研究,实验室试验结果表明:具有足够的水泥含量和低水灰比的混凝土路面砖,显示出很好的抗冻性能和抗除冰剂侵蚀的能力。高浓度碱土金属氯化物溶液对混凝土路面砖没有产生明显的损坏。Patrick Schffel Sebastian Palm Dietmar Ulonska 崔玉忠 2014建筑砌块与砌块建筑2014,,3:0
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