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| 1 | Innate Immunity and Neuroinflammation in the CNS:The Role of Microglia in Toll-Like Receptor-Mediated Neuronal Injury显示文摘小胶质细胞是中枢神经系统内的内源性免疫细胞,在中枢神经系统的固有免疫反应中扮演关键的角色,其主要作用是早期控制感染及激活适应性免疫系统细胞,以清除病原体。小胶质细胞引发的固有和适应性免疫反应包括前炎性因子的释放。虽然有效的免疫反应对于防御病原体的侵害是必须的,但中枢神经系统的炎症反应也会造成相应的组织损伤和神经退行性变化。Toll样受体是模式识别受体家族中一个主要成员,不仅介导固有免疫反应,也参与适应性免疫反应。通过Toll样受体,小胶质细胞能识别中枢神经系统内的病原体配体及宿主配体。虽然越来越多的证据表明Toll样受体信号通路调节中枢神经系统有益的保护反应,但其诱导的小胶质细胞活化及前炎症因子释放也介导多种中枢神经系统疾病病理过程中的神经毒性作用。因此,Toll样受体介导的小胶质细胞活化对中枢神经系统的最终作用,取决于二者之间微妙的平衡。本文主要评述中枢神经系统内Toll样受体信号通路调控的神经退行性作用。 | SEIJA LEHNARDT | 2010 | 神经损伤与功能重建2010，5，1： | 55 |
| 2 | Partial anterior cruciate ligament tears treated with intraligamentary plasma rich in growth factors显示文摘AIM:To evaluate the effect of the application of plasma rich in growth factors(PRGF)-Endoret to the remaining intact bundle in partial anterior cruciate ligament(ACL)tears.METHODS:A retrospective review of the rate of return to play in football players treated with the application of PRGF-Endoret in the remaining intact bundle in partial ACL injuries that underwent surgery for knee instability.Patients with knee instability requiring revision surgery for remnant ACL were selected.PRGF was applied in the wider part of posterolateral bundle and the time it took patients to return to their full sporting activities at the same level before the injury was evaluated.RESULTS:A total of 19 patients were reviewed.Three had a Tegner activity level of 10 and the remaining 16level 9.The time between the injury and the time of surgery was 5.78 wk(SD 1.57).In total,81.75%(16/19)returned to the same pre-injury level of sport activity(Tegner 9-10).17 males and 2 females were treated.The rate of associated injury was 68.42%meniscal lesions and 26.31%cartilage lesions.The KT-1000 values were normalized in all operated cases.One patient was not able to return to sport due to the extent of their cartilage lesions.The 15 patients with Tegner activity level 9 returned to play at an average of 16.20 wk(SD1.44)while the 3 patients with Tegner activity level 10did so in 12.33 wk(SD 1.11).CONCLUSION:With one remaining intact bundle the application of PRGF-Endoret in instability cases due to partial ACL tear showed high return to sport rates at pre-injury level in professional football players. | Roberto Seijas Oscar Ares Xavier Cuscó Pedro lvarez Gilbert Steinbacher Ramón Cugat | 2014 | World Journal of Orthopedics2014，5，3： | 3 |
| 3 | Solvent-free synthesis of functionalized flavones under microwave irradiation 显示文摘 | Seijas J A Vazquez-Tato M P Carballido-Reboredo R | 2005 | J Org Chem2005，70，7： | 1 |
| 4 | Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer显示文摘 | Jian-Ping Guo Shao-Kun Shu Lili He Yi-Chun Lee Patricia A. Kruk Seija Grenman Santo V. Nicosia Gil Mor Michael J. Schell Domenico Coppola Jin Q. Cheng | 2009 | The American Journal of Pathology2009，，1： | 1 |
| 5 | Terrible triad of the elbow-role of the coronoid process:a case report显示文摘 | Seijas R Joshi N Hernandez A | | 0，，03： | 1 |
| 6 | Terrible triad of the elbow : role of the coronoid process, A case repori显示文摘 | Seijas R Joshi N Hemandez A | 2005 | J Orthop Surg( Hong Kong)2005，13，3： | 1 |
| 7 | Understanding failure mechanisms to improve reliability of coke drums显示文摘 | Penso J A Lattarulo Y M Seijas A J | 1999 | American Society of Mechanical Engineers Pressure Vessels and Piping Division (Publication) PVP1999，395，： | 1 |
| 8 | Sepsis caused by New Delhi metallo-β-lactamase(bla NDM-1)and qnr Dproducing Morganella morganii,treated successfully with fosfomycin and meropenem:case report and literature review显示文摘 | Seija V Medina Presentado JC Bado I | 2015 | Int J Infect Dis2015，30，： | 1 |
| 9 | Degradation Half life Times of PCDDs, PCDFs and PCBs for Environmental Fate Modeling显示文摘 | Sinkkonen Seija Paasivirta Jaakko | 2000 | Chemosphere2000，40，911： | 1 |
| 10 | Magnetic resonance imaging evaluation of patellar tendon graft remodelling after anterior cruciate ligament reconstruction with or without platelet-rich plasma显示文摘 | Seijas Roberto Ares Oscar Catala Jordi Alvarez-Diaz Pedro Cusco Xavier Cugat Ramon | 2013 | Journal of Orthopaedic Surgery2013，，1： | 1 |
| 11 | Expertise in Translation显示文摘 | Siren Seija & Kai Hakkarainen | 2002 | Across Languages and Cultures2002，，1： | 1 |
| 12 | Comparison of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) versus Durolane hyaluronic acid in the treatment of patients with symptomatic osteoarthritis: A randomized controlled trial显示文摘 | Víctor Vaquerizo Miguel ángel Plasencia Ignacio Arribas Roberto Seijas Sabino Padilla Gorka Orive Eduardo Anitua | 2013 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2013，，： | 1 |
| 13 | The effect of preoperative fasting on postoperative pain, nausea and vomiting in pediatric ambulatory tonsillectomy 显示文摘 | Seija K Ilpo K Tarja S | 2009 | Int J Ped orl2009，73，2： | 1 |
| 14 | Clavicular hook plate for grade-III acromioclavicular dislocation显示文摘 | Steinbacher G Sallent A Seijas R | 2014 | J Or- thop Surg( Hong Kong)2014，22，3： | 1 |
| 15 | Synthesis of anacardic acids by nucleophilis substitution on 2-aryloxazolines显示文摘 | Seijas JA Vizouez-Tatomp MP Martinez MM | 2004 | Tetrahedron Lett2004，45，9： | 1 |
| 16 | Life cycle strategies of bloom-forming,filamentous cyanobacteria in the Baltic Sea显示文摘 | Sanna S Hermanni K Seija H | 2010 | Deep-Sea Research Ⅱ2010，57，： | 1 |
| 17 | Structural characteristics and chemical composition of birch(Betula pendula) leaves are modified by increasing CO2 and ozone显示文摘 | Elina O Johanna R Seija K | 2005 | Global Change Biology2005，11，5： | 1 |
| 18 | Serum HE4 Profile During Primary Chemotherapy of Epithelial Ovarian Cancer显示文摘 | Johanna Hynninen Annika Auranen Kirsti Dean Maija Lavonius Olli Carpen Antti Perheentupa Marko Sepp?nen Seija Grénman | 2011 | International Journal of Gynecological Cancer2011，，9： | 1 |
| 19 | Oncogenic osteomalacia: two case reports with surprisingly different outcomes 显示文摘 | Seijas R Ares O Sierra J | 2009 | Arch Orthop Trauma Surg2009，129，4： | 1 |
| 20 | Quadriceps and patellar tendon ruptures显示文摘 | Seijas R Steinbacher G Rius M | 2010 | Tech Knee Surg2010，9，3： | 1 |
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