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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Mesh stability of look-ahead inter connected systems显示文摘 | Pant A Seiler P Hedrick J K | | 0，，0018： | 1 |
| 3 | Development of a Colli- sion Avoidance System显示文摘 | SEILER P SONG B HEDRICK J | 1998 | SAE1998，，98： | 1 |
| 4 | Gas exchange and canopy structure of 9-year-old loblolly pine,pitch pine and pitch × loblolly hybrids 显示文摘 | Samuelson L J Seiler J R Feret P P | 1992 | Trees1992，6，： | 1 |
| 5 | Evaluation and bioinduction of energy components of Jatropha curcas显示文摘 | AUGUSTUS G D P S JAYABALAN M SEILER G J | 2002 | Biomass and Bioenergy2002，23，： | 1 |
| 6 | Estimates of gross and net fluexs of carbon between the biosphere and the atmosphere from hiomass burning显示文摘 | Seiler W Crutzen P J | 1980 | Clim Chang1980，2，3： | 1 |
| 7 | Estimates of gross and net fluxes of carbon between the biosphere and the atmosphere from biomass burning显示文摘 | SEILER W G CRUTZEN P J | 1980 | Climate Change1980，2，3： | 1 |
| 8 | Evaluation and bioinduction of energy components of Jatropha curcas 显示文摘 | Augustusa G D P S Jayabalan M Seiler G J | 2002 | Biomass and Bioenery2002，23，： | 1 |
| 9 | Role of quail in the interspeciestransmission of H9 influenza A viruses : molecular changes on HA thatcorrespond to adaptation from ducks to chickens 显示文摘 | PerezD R Lim W Seiler J P | 2003 | Joumal ofVirology2003，77，5： | 1 |
| 10 | The role of perforin and Fas - de- pendent cytotoxiciy in protection against cytopathic and noncytopathic viruses 显示文摘 | Kagi S P Seiler J Pavlovic B etal | 1995 | lmmunol1995，25，： | 1 |
| 11 | A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site : e,Jidence for C - F… = O interactions显示文摘 | Olsen J A Banner D W Seiler P | 2003 | Angew Chem Int Ed2003，115，： | 1 |
| 12 | Estimates of gross and net fluxes of carbon between the biosphere and the atmosphere from biomass burning显示文摘 | Seiler W Crutzen P J | 1980 | Clim Change1980，2，： | 1 |
| 13 | Estimates of gross and net fluexs of carbon between the biosphere and the atmosphere from biomass burning 显示文摘 | Seiler W Crutzen P J | 1980 | Climatic Change1980，2，3： | 1 |
| 14 | Adaptation of pandemic H1N1 influenza viruses in mice显示文摘 | Ilyushina N A Khalenkov A M Seiler J P | 2010 | J Virol2010，84，17： | 1 |
| 15 | Estimates of gross and net fluxes of carbon between the biosphere and the atmosphere from biomass burning显示文摘 | Seiler W Crutzen P J | 1980 | Climate Change1980，2，： | 1 |
| 16 | Gas exchange and canopy structure of 9-year-old loblolly pine, pitch pine and pitch loblolly hybrids 显示文摘 | Samuelson L J Seiler J R Feret P P | 1992 | Trees1992，6，： | 1 |
| 17 | Development of a collision warning system显示文摘 | Seiler P Song B Hedrick K J | 1998 | SAE1998，，： | 1 |
| 18 | Estimates of gross and net fluxes of carbon between the biosphere and the atmosphere from biomass burning显示文摘 | Seiler W Crutzen P J | 1980 | Climatic Change1980，2，： | 1 |
| 19 | Role of Quail in the interspecies transmission of H9 influenza A viruses:molecular changes on HA that correspond to adaptation from ducks to chickens显示文摘 | Perez D R Lim W Seiler J P | 2003 | J Virol2003，77，： | 1 |
| 20 | Model reduction for aeroservoelastic systems 显示文摘 | Moreno C P Seiler P J Balas G J | 2014 | Journal of Aircraft2014，51，1： | 1 |
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