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| 1 | Activins and activin antagonists in hepatocellular carcinoma显示文摘In many parts of the world hepatocellular carcinoma (HCC)is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood.There is increasing evidence that activins,which are members of the transforming growth factorβ(TGFβ)superfamily of growth and differentiation factors,could play important roles in liver carcinogenesis.Activins are disulphide-linked homo- or heterodimers formed from four differentβsubunits termedβA,βB,βC,andβE,respectively.Activin A, the dimer of twoβA subunits,is critically involved in the regulation of cell growth,apoptosis,and tissue architecture in the liver,while the hepatic function of other activins is largely unexplored so far.Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG,and at the cell membrane antagonistic coreceptors like Cripto or BAMBI.Additionally,in the intracellular space inhibitory Smads can modulate and control activin activity.Accumulating data suggest that deregulation of activin signals contributes to pathologic conditions such as chronic inflammation,fibrosis and development of cancer.The current article reviews the alterations in components of the activin signaling pathway that have been observed in HCC and discusses their potential significance for liver tumorigenesis. | Alev Deli Emanuel Kreidl Stefan Santifaller Barbara Trotter Katja Seir Walter Berger Rolf Schulte-Hermann Chantal Rodgarkia-Dara Michael Grusch | 2008 | World Journal of Gastroenterology2008，14，11： | 8 |
| 2 | Municipal solid waste composition studies显示文摘 | MCCAULEY BELL REINHART D SEIR H | 1997 | ASCE Practice Periodical of Hazardous and Radioactive Waste1997，1，4： | 2 |
| 3 | Effect of variable light intensity on composite shrinkage显示文摘 | Dennison J P Yaman P Seir R Hamilton J C | 2000 | J Prosthet Dent2000，84，5： | 1 |
| 4 | Ultras ono- graphicevaluation of joint involvement in early rheumatoid arthrit is inclinical remission : power doppler signal predics short termrelapse 显示文摘 | Seire CA Mon tecuceo C Cndullo V | 2009 | Rheumatology2009，48，9： | 1 |
| 5 | Effect of variable light intensity on composite shrinkage 显示文摘 | Dennison JB Yaman P Seir R | 2000 | J Pmsthet Dent2000，84，5： | 1 |
| 6 | Plasma procalcitonin in rheumatic diseases显示文摘 | Seire CA Capotali R Perotti C | | 0，，02： | 1 |
| 7 | Comparing open and sealed bid auctions evidence from timber auctions显示文摘 | Susan Athey Jonathan Levin Enrique Seir | 2011 | Quarterly Journal of Economics 12011，126，1： | 1 |
| 8 | Acetylated and hydroxypropylated wheat starch: paste and gel properties compared with modified maize and tapioca starched显示文摘 | TAKAHSSHI S MANINGAT C SEIR P | 1989 | Cereal Chemistry1989，66，6： | 1 |
| 9 | A Mathematical Programming Method for Design of Elastics Bodies in Contact显示文摘 | SEIRE A | 1971 | Journal of Applied Mechanics Transactions of ASME1971，，6： | 1 |
| 10 | Surgical treatment of Graves' disease:subtotal thyroidectomy might still be the preferred option显示文摘 | Lepner U Seire I Palmiste V | 2008 | Medicina (Kaunas)2008，44，1： | 1 |
| 11 | The surface firmness of cooked noodles from soft and hard wheat flour 显示文摘 | Oh N H Seir P A Deyoe C W | 1985 | Cereal Chemistry1985，62，6： | 1 |
| 12 | Circulating levels of os- teopontin are related with calcification paramete in patients with renal transplantations显示文摘 | Karakan S Seir S Ozdenir Acar FN | 2011 | Transplant Proc2011，43，2： | 1 |
| 13 | Tissue levels of matrix metalloproteinases MMP - 2 and MMP - 9 are related to the overall survival of patients with gastric carcinoma显示文摘 | Seir CFM Kubberm FJGM Ganesh S | 1996 | By J Cancer1996，74，： | 1 |
| 14 | Embryonic, larval and juvenile development of the roughskin sculpin,Trachidermus fasciatus (Scorpaeniformes: Cottidae)显示文摘 | Naohiko Takeshita Norio Onikura Seiichi Matsui Seir? Kimura | 1997 | Ichthyological Research (-)1997，，2： | 1 |
| 15 | Phosphoprotein extraction from the dentine/cementum complex of human tooth roots显示文摘 | Clarkson BH Seirs RL | 1990 | Arch Oral Biol1990，35，5： | 1 |
| 16 | Embryonic, larval and juvenile development of the roughskin sculpin,Trachidermus fasciatus (Scorpaeniformes: Cottidae)显示文摘 | Naohiko Takeshita Norio Onikura Seiichi Matsui Seir? Kimura | 1997 | Ichthyological Research (-)1997，，2： | 1 |
| 17 | Circulating levels of osteopontin are related with calcification parameters in patients with renal transplantations显示文摘 | Karakan S Seir S zdenir Acar FN | | 0，，02： | 1 |
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