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| 1 | Chronic HCV infection and inflammation:Clinical impact on hepatic and extra-hepatic manifestations显示文摘The liver has a central role in regulating inflammation by its capacity to secrete a number of proteins that control both local and systemic inflammatory responses. Chronic inflammation or an exaggerated inflammatory response can produce detrimental effects on target organs. Chronic hepatitis C virus(HCV) infection causes liver inflammation by complex and not yet well-understood molecular pathways, including direct viral effects and indirect mechanisms involving cytokine pathways,oxidative stress and steatosis induction. An increasing body of evidence recognizes the inflammatory response in chronic hepatitis C as pathogenically linked to the development of both liver-limited injury(fibrosis, cirrhosis and hepatocellular carcinoma) and extrahepatic HCV-related diseases(lymphoproliferative disease,atherosclerosis, cardiovascular and brain disease). Defining the complex mechanisms of HCV-induced inflammation could be crucial to determine the global impact of infection, to estimate progression of the disease, and to explore novel therapeutic approaches to avert HCVrelated diseases. This review focuses on HCV-related clinical conditions as a result of chronic liver and systemic inflammatory states. | Rosa Zampino Aldo Marrone Luciano Restivo Barbara Guerrera Ausilia Sellitto Luca Rinaldi Ciro Romano Luigi E Adinolfi | 2013 | World Journal of Hepatology2013，5，10： | 13 |
| 2 | Chronic hepatitis C virus infection and neurological and psychiatric disorders:An overview显示文摘Hepatitis C virus(HCV)infection is considered a systemic disease because of involvement of other organs and tissues concomitantly with liver disease.Among the extrahepatic manifestations,neuropsychiatric disorders have been reported in up to 50%of chronic HCV infected patients.Both the central and peripheral nervous system may be involved with a wide variety of clinical manifestations.Main HCV-associated neurological conditions include cerebrovascular events,encephalopathy,myelitis,encephalomyelitis,and cognitive impairment,whereas'brain fog',depression,anxiety,and fatigue are at the top of the list of psychiatric disorders.Moreover,HCV infection is known to cause both motor and sensory peripheral neuropathy in the context of mixed cryoglobulinemia,and has also been recently recognized as an independent risk factor for stroke.These extrahepatic manifestations are independent of severity of the underlying chronic liver disease and hepatic encephalopathy.The brain is a suitable site for HCV replication,where the virus may directly exert neurotoxicity;other mechanisms proposed to explain the pathogenesis of neuropsychiatric disorders in chronic HCV infection include derangement of metabolic pathways of infected cells,alterations in neurotransmitter circuits,autoimmune disorders,and cerebral or systemic inflammation.A pathogenic role for HCV is also suggested by improvement of neurological and psychiatric symptoms in patients achieving a sustained virologic response following interferon treatment;however,further ad hoc trials are needed to fully assess the impact of HCV infection and specific antiviral treatments on associated neuropsychiatric disorders. | Luigi Elio Adinolfi Riccardo Nevola Giacomo Lus Luciano Restivo Barbara Guerrera Ciro Romano Rosa Zampino Luca Rinaldi Ausilia Sellitto Mauro Giordano Aldo Marrone | 2015 | World Journal of Gastroenterology2015，21，8： | 6 |
| 3 | Methodological approaches for kinematic coupling of non-matching finite element meshes显示文摘 | Sellitto A Borrell R Caputo F | 2011 | Procedia Engineering2011，10，： | 1 |
| 4 | Oocyte-granulosa cell heterologous gap junction are required for the coordination of nuclear and cytoplasmic meiotic competence 显示文摘 | Carabatsos M J Sellitto C Goodenough DA | 2000 | Dev Biol2000，226，2： | 1 |
| 5 | The Role of User-Generated Content in Tourists' Travel Planning Behavior 显示文摘 | Cox C Burgess S Sellitto C | 2009 | Journal of Hospitality Marketing & Management2009，，8： | 1 |
| 6 | Prenatal lens development in connexin43 and connexinS0 double knockout mice 显示文摘 | White TW Sellitto C Paul DL | 2001 | Invest Ophthalmol Vis Sci2001，42，： | 1 |
| 7 | Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36显示文摘 | Deans MR Gibson JR Sellitto C | 2001 | Neuron2001，31，3： | 1 |
| 8 | Amino acid-based formula as a rescue strategy in feeding very-low-birth-weight infants with intrauterine growth restriction 显示文摘 | Raimondi F Spera AM Sellitto M | 2012 | J Pediatr Gastro- enterol Nutr2012，54，： | 1 |
| 9 | A study of missing web-cites in scholarly ar- ticles: towards an evaluation framework 显示文摘 | Sellitto C | 2004 | Journal of Information Science2004，30，6： | 1 |
| 10 | Behavior of circulating CD4+ CD25 + FOXP3+ regulatory T ceils in colon cancer patients undergoing surgery 显示文摘 | Sellitto A Galizia G De Fanis U | 2011 | J Clin Immunol2011，31，6： | 1 |
| 11 | Amino acid - based for- mula as a rescue strategy in feeding very-low-birth-weight infants with intrauterine growth restriction显示文摘 | Raimondi F Spera AM Sellitto M | 2012 | Pediatr Gastroenterol Nu- tr2012，54，5： | 1 |
| 12 | Aberrant connexin26 hemichannels underlying keratitis ichthyosis deafness syndrome are potently inhibited by mefloquine显示文摘 | Levit NA Sellitto C Wang HZ | 2015 | J Invest Deimatol2015，135，4： | 1 |
| 13 | A study of missing web-cites in scholarly articles: towards an evaluation framework显示文摘 | Sellitto C | 2004 | Journal of Information Science2004，30，6： | 1 |
| 14 | Polyacrylamide gel electrophoresis in discontinuous transverse urea-gradient gels显示文摘 | Gentile F Veneziani B M Sellitto C | 1997 | Analytical Biochemistry1997，244，2： | 1 |
| 15 | Trust perceptions of online travel information by different content creators:Some social and legal implications显示文摘 | Burgess S Sellitto C Cox C | 2009 | Service Industries Journal2009，15，2： | 1 |
| 16 | Trust Percep-tions of Online Travel Information by Different Content Creators:Some social and legal implications 显示文摘 | Burgess S Sellitto C Cox C Buultjens J | 2009 | Infor-mation Systems Frontiers:A Journal of Research and In-novation2009，15，2： | 1 |
| 17 | Water-soluble carbon nanotube-enzyme conjugates as function- al biocatalytic formulations显示文摘 | ASURI P KARAJANAGI S S SELLITTO E | 2006 | Biotechnol Bioeng2006，95，5： | 1 |
| 18 | Short 9q interstitial deletion in a neonate with lethal non - immune hydrops 显示文摘 | Sellitto M Genesio R Conti A | 2008 | Am J Med Genet A2008，146，19： | 1 |
| 19 | Prenatal lens development in connexin43 and connexin50 double knockout mice显示文摘 | White TW Sellitto C Paul DL | 2001 | Invest Ophthalmol Vis Sci2001，42，12： | 1 |
| 20 | Analysis of seven maternal polymorphisms of genes involved in homocysteine/folate metabolism and risk of Down syndrome offspring 显示文摘 | Scala 1 Granese B Sellitto M | 2006 | Genet Med2006，8，7： | 1 |
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