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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Transcutaneous bilirubin measurement: a multicenter evaluation of a new device显示文摘 | Rubaltelli FF Gourley GR Loskamp N Modi N Roth-Kleiner M Sender A | 2001 | Pediatrics2001，107，6： | 1 |
| 3 | Serum paraoxonase- 3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary ar- tery disease 显示文摘 | RULL A GARCIA R FERNANDEZ SENDER L | 2012 | Atherosclerosis2012，220，2： | 1 |
| 4 | Efficacy and safety of abotulinumtoxina in patients with urinary incontinence due to neurogenic detrusor overactivity : a randomised, double-minded, placebocontrolled trial显示文摘 | Francisco C Sender H Philip A | 2011 | European Urology2011，60，： | 1 |
| 5 | Toxicological aspects of cyclamate and cyclohexylamine 显示文摘 | Bopp B A Senders R C Kesterson J W | 1986 | Crit Rev Toxicol1986，16，3： | 1 |
| 6 | Social Media Affecting Tour Operators' Customer Loyalty显示文摘 | Senders A Govers R Neuts B(2013) | 2013 | Journal of Travel and Tourism Marketing2013，4157，： | 1 |
| 7 | The R&D Marketing Interface:Results from an Empirical Study of Innovation Projects 显示文摘 | W E Sender A K Chakrabart | 1978 | Ieee Trans- actions on Engineering Management1978，25，： | 1 |
| 8 | Toxicological aspects of cyclamate and cyclohexylamine显示文摘 | BOPP B A SENDERS R C KESTERSON J W | 1986 | Crit Rev Toxicol1986，16，3： | 1 |
| 9 | Management of bilateral cleft lip and nasal deformity显示文摘 | SENDERS C W | 2006 | Curr Opin Otolaryngol Head Neck Surg2006，14，4： | 1 |
| 10 | The effect of hu- man albumin in association with intensive phototherapy in the management of neonatal jaundice 显示文摘 | Caldera R Maynier M Sender A | 1993 | Arch Fr Pedi- atr1993，50，39： | 1 |
| 11 | Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease显示文摘 | RULL A GARC(I)A R FERNNDEZ SENDER L | | 0，，10： | 1 |
| 12 | Perceived stress in multiple sclerosis the potential role of mindfulness in health and wellbeing显示文摘 | Senders A Bourdette D Hanes D | 2014 | Journal of Evidence-Based Complementary and Alternative Medicine2014，19，2： | 1 |
| 13 | Bovine lactoferrin gene polymorphism and expression in relation to mastitis resist- ance a review显示文摘 | Pawlik A Sender G Korwin-Kossakowska A | 2009 | Anita Sci Pap Rep2009，27，： | 1 |
| 14 | Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior显示文摘 | Bhat A Boyadjiev SA Senders CW | 2011 | PLoS One2011，6，25： | 1 |
| 15 | Toxicological aspects ofcyclamate and cyclohexylamine显示文摘 | BOPP B A SENDERS R C KESTERSON J W | 1986 | Crit Rev Toxicol1986，16，3： | 1 |
| 16 | Social media affecting tour operators' customer loyalty显示文摘 | Senders A Govers R Neuts B | 2013 | Journal of Travel & Tourism Marketing2013，30，12： | 1 |
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