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| 1 | 腹壁疝补片修补相关感染:病理学、治疗和结局显示文摘目的分析应用合成补片行疝修补后出现需要去除补片的手术部位感染并发症病人的临床及人口统计学特点,补片植入手术的细节以及感染发生后的治疗和结局。方法从病人资料表中获得病人的感染相关因素(人口统计学参数、疝修补术特点和使用的网片)。收集32例连续病例的标本(补片和组织),行细菌培养和显微镜检查。前瞻性评估补片取出后的结局。结果 22例接受了切口疝修补术,10例接受了腹股沟疝修补术,大部分病人手术时间较长,28例出现过早期伤口并发症(浆液肿或血肿)。在'补片植入-取出'间期,部分病人进行了保守治疗,例如局麻下引流或者窦道切除。22例的网片被完全取出(其中9例是补片部分取出后),其余10例部分取出补片治疗有效。大部分补片(24例)是多纤丝聚丙烯网片,补片周围组织的显微镜观察发现有白细胞浸润、巨细胞反应、胶原纤维无序排列以及脓肿形成。32例共进行了51例次手术治疗,补片取出后,有6例复发和2例肠瘘。平均随访时间为40(30~97)个月。结论大多数需要去除补片的感染病例前次疝修补术时间较长,并且有未经治疗的术后早期伤口并发症。补片部分取出通常不会成功,而且会带来并发症。取出全部补片的外科探查手术应该在全麻下进行。 | Tolino MJ Tripoloni DE Ratto R Garcia MI | 2010 | 中国实用外科杂志2010，30，12： | 20 |
| 2 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 3 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 4 | 维生素C和维生素E减轻热应激改善蛋鸡活质量和蛋品质显示文摘试验为研究维生素C和维生素E对热应激下蛋鸡活质量和蛋品质的影响。试验选用720羽39周龄白莱航蛋鸡,随机分为4个处理组,各组分别添加0、150 mg/kg维生素C、150 mg/kg(150 IU)维生素E和150 mg/kg维生素C+150 mg/kg维生素E。试验结束时各试验组的最终活质量、蛋质量、蛋黄质量、蛋清质量和蛋壳质量都显著高于对照组(P<0.05),其中添加维生素C+维生素E组的蛋壳质量最高。通过对蛋鸡活质量和蛋品质指标的跟踪观察发现,抗氧化添加剂的加入能缓解热应激造成的不良影响。 | J J Ajakaiye M Cuesta - Mazorra J R Garcia - Diaz 黄鑫 李彪 谭斌 | 2013 | 饲料研究2013，36，7： | 3 |
| 5 | Evaluation of heavy metal availability in polluted soils by two sequential extraction procedures using factor analysis显示文摘 | I Maiz I Arambarri R Garcia E Millán | 2000 | Environmental Pollution2000，，1： | 2 |
| 6 | Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis显示文摘 | Martin Briand Jean G. Dumesnil Lyes Kadem Antonio G. Tongue Régis Rieu Damien Garcia Philippe Pibarot | 2005 | Journal of the American College of Cardiology2005，，2： | 2 |
| 7 | Chlorophyll meter estimates leaf area based nitrogen concentration of rice 显示文摘 | Peng S B Laza R C Garcia F V | 1995 | Communication of Soil Science and Plant Analysis1995，26，： | 1 |
| 8 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 9 | Effect of enzyme addition to wheat-,barley-and rye-based diets on nutrient digestibility and performance of laying hens显示文摘 | Lazaro R Garcia M Aranibar M J | 2003 | British Poultry Science2003，44，2： | 1 |
| 10 | Reliability and predictive validity of the Motivated Strategies for Learning Questionnaire (Mslq)显示文摘 | Pintrich P R Smith D A F Garcia T | 1993 | Educational and Psychological Measurement1993，53，3： | 1 |
| 11 | osteosarcoma显示文摘 | MESSERSCHMITT P J GARCIA R M ABDUL-KARIM F W | 2009 | J Am Acad Orthop Surg2009，17，8： | 1 |
| 12 | Trans-fissural or transsulcal approach versus combined stereotaetic-microsurgieal approach 显示文摘 | Garcia Sola R Pulido P Kusak E | 1991 | Acta Neuroehir Suppl (Wien)1991，52，： | 1 |
| 13 | A cortical neuropeptide with neuronal depressant and sleep - modulating properties 显示文摘 | DELECEA L CRIADO J R PROSPERO - GARCIA O | 1996 | Nature1996，381，6579： | 1 |
| 14 | Antibiotic bisanthraquinones produced by a Slxeptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinate 显示文摘 | SOCHA A M GARCIA D SHEFFER R | 2006 | J Nat Prod2006，69，7： | 1 |
| 15 | Gloom and doom? The future of marine capture fisheries显示文摘 | Garcia Grainger J R | 2005 | Philosophical Tanscations of the Royal Society2005，360，： | 1 |
| 16 | Glutamic acid and Alzheimer's disease显示文摘 | Arias CB Garcia F Tapia R | 1998 | Neurobiology1998，6，2： | 1 |
| 17 | Renal angiotensin Ⅱ receptor regulation in two kidney, one clip hypertensive rats:effect of ACE inhibition 显示文摘 | AMIRI F GARCIA R | 1997 | Hypertension1997，30，： | 1 |
| 18 | Effects of extremely hot dayson people older than 65 years in Seville (Spain) from 1986 to 1997显示文摘 | Diaz J Garcia R Velazquez | 2002 | Int J Biometeorol2002，46，： | 1 |
| 19 | Tuning the performance of room temperat urephosphorescence sensing materials for oxygen using factorial designs显示文摘 | Badia R Garcia M E Diaz | 2000 | A nal Lett2000，33，2： | 1 |
| 20 | Strontium-89 for palliation of pain from bone metastases in patients with prostate and breast cancer显示文摘 | Pons F Herranz R Garcia A | 1997 | Eur J Nucl Med1997，24，： | 1 |
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