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| 1 | Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs显示文摘The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs. | Hakhyun Ka Heewon Seo Yohan Choi Inkyu Yoo Jisoo Han | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 2 | Is routine iron supplementation needed during gestation?显示文摘 | Park CH Lee JK Seo KA | 2003 | J Obstet Gynecol Res2003，29，3： | 1 |
| 3 | Displacement pattern of the anterior segment using antero-posterior lingual retractor combined with a palatal plate显示文摘 | Seo KW Kwon SY Kim KA | 2015 | Korean J Orthod2015，45，6： | 1 |
| 4 | Cytochrome P450 2B6 catalyzes the formation of pharmacologically ac- tive sibutramineN- { 1--3-methylbutyl} N, N-dimethylamine) metabo- lites in human liver microsomes显示文摘 | Bae SK Cao S Seo KA | 2008 | Drug Metab Dispos2008，36，8： | 1 |
| 5 | Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandinendoperoxide synthase 2 expression in the porcine uterus显示文摘 | Seo H Kim M Choi Y Lee CK Ka H | | 0，，12： | 1 |
| 6 | Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone byCYP3A4 and 3A5显示文摘 | SEO KA LEE SJ KIM KB | 2012 | Xenobiotica2012，42，3： | 1 |
| 7 | Is Routine lron Sulpplementation显示文摘 | Park CH Lee JK Seo KA | 2003 | Needed During Gestation J Obstet Gynaecol Res2003，29，： | 1 |
| 8 | Ilaprazole, a new proton pump inhibi- tor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5 显示文摘 | Seo KA Lee SJ Kim KB | 2012 | Xenobiotica2012，42，3： | 1 |
| 9 | Differentiation of recently infarcted myocardium from chronic myocardial scar:the value of contrast-enhanced SSFP-based cine MR imaging显示文摘 | Kim KA Seo JB Do KH | 2006 | Korean J Radiol2006，7，1： | 1 |
| 10 | Second-look arthroscopic find-ings after repairs of posterior root tears of the medialmeniscus 显示文摘 | Seo HS Lee SC Jung KA | 2011 | Am J Sports Med2011，39，1： | 1 |
| 11 | Quantitativeanalysis of exnperi- mental peritumoral edema in cats显示文摘 | Hossmann KA Seo K Szymas J | 1990 | Adv Neurol1990，52，： | 1 |
| 12 | Coordination of multiple dual oxidase -regulatory pathways in responses to commensal and infectious microbes in Drosophila gut 显示文摘 | Ha EM Lee KA Seo YY | 2009 | Nat Immunol2009，10，9： | 1 |
| 13 | The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil显示文摘 | KU HY AHN HJ SEO KA et 01 | 2008 | Drug Metab Dispos2008，36，6： | 1 |
| 14 | Low serum concen- trations o{ moxi{显示文摘 | Lee SH Seo KA Lee YM | 2015 | Yonsei Med J2015，56，4： | 1 |
| 15 | Quantitativeanalysis of experimental peritumoral edema in cats 显示文摘 | Hossmann KA Seo K Szymas J | 1990 | Adv Neurol1990，52，： | 1 |
| 16 | Quantitative analysis of experimental peritumoral edema in cats显示文摘 | Hossmann KA Seo K Szymas J | 1990 | ADV Neurol1990，52，： | 1 |
| 17 | Calcium extrusion regulatory molecules: differential expression during pregnancy in the porcine uterus显示文摘 | Y. Choi H. Seo J. Shim I. Yoo H. Ka | 2013 | Domestic Animal Endocrinology2013，，： | 1 |
| 18 | Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chro- matography/tandem mass spectrometl'y 显示文摘 | Kim KB Seo KA Kim SE | 2011 | Journal of Pharmaceu- tical and Biomedical Analysis2011，56，4： | 1 |
| 19 | Ilaprazole, a new proton pump inhibitor,is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3 A5 显示文摘 | Seo KA Lee S J Kim KB | 2012 | Xenobiotica2012，42，3： | 1 |
| 20 | Low Serum Concen- trations of Moxifloxacin, Prothionamide, and Cy- closerine on Sputum Conversion in Multi-Drug Resist- ant TB显示文摘 | Lee SH Seo KA Lee YM | 2015 | Yonsei Med J2015，56，4： | 1 |
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