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| 1 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 2 | Serotonergic modulation of mismatch negativity 显示文摘 | Seppo K Ville M Iiro PJ | 2005 | Psychiatry Research : Neuroimaging2005，138，： | 1 |
| 3 | Reversible surface binding of cadmium and lead by lactic acid and bifidobacteria显示文摘 | Teemu H Seppo S Jussi M | 2008 | International journal of food microbiology2008，125，2： | 1 |
| 4 | Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryo显示文摘 | SEPPO A MORELAND M SCHWEINGRUBER H | 2000 | Eur J Bio chem2000，267，12： | 1 |
| 5 | Low plasma ghrelin is associated with insulin resistance,hypertension,and the prevalence of type 2 diabetes显示文摘 | Seppo M P Eija K Sohvi H | 2003 | Diabetes2003，52，10： | 1 |
| 6 | Adhesion of some probiotic and dairy Lactobacillus strains to Caco-2 cell cultures显示文摘 | Elina M T Seppo J S | 1998 | Int J Food Microbiol1998，41，： | 1 |
| 7 | In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal mucus显示文摘 | CARMEN COLLADO M JUSSI M SEPPO S | 2007 | Food Res Intern2007，40，5： | 1 |
| 8 | Indicators measuring university-industry cooperation显示文摘 | SEPPO M LILLES A | 2012 | Social Science Electronic Publishing2012，20，1： | 1 |
| 9 | The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats显示文摘 | Sanna J Paula M P(a)ivi P Raimo KT Liisa A Seppo K | | 0，，： | 1 |
| 10 | Adhersion of two Lactobacillus strains,one lactoeoceus and one propionibacterium strain to cultured human intestinal Caco-2 cell line显示文摘 | Elina M LEHTO Seppo S | 1997 | Bioscience Mieroflora1997，16，1： | 1 |
| 11 | Risk Factors for Anastomotic Leakage After Left-Sided Colorectal Resection With Rectal Anastomosis显示文摘 | Jyrki T. M?kel? M.D. Heikki Kiviniemi M.D. Seppo Laitinen M.D | 2003 | Diseases of the Colon & Rectum2003，，5： | 1 |
| 12 | Power Prediction in Mobile Communication Systems Using an Optimal Neural-Network Structure 显示文摘 | Xiao Ming Gao Xiao Zhi Gao Jarno M A Seppo J Ovaska | 1997 | IEEE Transactions on Neural Networks1997，8，6： | 1 |
| 13 | Adhersion of two lactobacillus strains, one lactococcus and one propionibacterium strain to cultured human intestinal Caco-2 cell line 显示文摘 | LEHTO Seppo S | 1997 | Bioscience Microflora1997，16，1： | 1 |
| 14 | In vitro analysis of probiotic strain combinations to inhibit pathogen adhesion to human intestinal- mucus 显示文摘 | CARMEN COLLADO M JUSSIM SEPPO S | 2007 | Food Res Intern2007，40，5： | 1 |
| 15 | Low plasma ghrelin is associated with insulin resistance,hypertension,and the prevalence of type 2 diabetes显示文摘 | Seppo M Poykko Eija Kellokoski Sohvi Horkko | | 0，，： | 1 |
| 16 | Mortalityfrom coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction 显示文摘 | Steven M Haffner MD Seppo Lehto MD | 1998 | N Engl J Med1998，339，： | 1 |
| 17 | Epidural analgesia diminished pain but did not otherwise improve enhanced recovery after laparoscopic sigmoidectomy: a prospective randomized study显示文摘 | Pertti Turunen Monika Carpelan-Holmstr?m Pekka Kairaluoma Heidi Wikstr?m Olli Kruuna Pertti Pere Martina Bachmann Seppo Sarna Tom Scheinin | 2009 | Surgical Endoscopy2009，，1： | 1 |
| 18 | Reversible surface binding of cadmium and lead by lactic acid and bifidobacteria显示文摘 | Teemu H Seppo S Jussi M | 2008 | Int J Food Microbiol2008，125，2： | 1 |
| 19 | Model Computations on the Effects of Elevating Temperature and Atmospheric CO2 on the Regeneration of Scots Pine at the Timber Line in Finland显示文摘 | Seppo Kellom?ki Hannu V?is?nen Taneli Kolstr?m | 1997 | Climatic Change1997，，4： | 1 |
| 20 | Risk Factors for Anastomotic Leakage After Left-Sided Colorectal Resection With Rectal Anastomosis显示文摘 | Jyrki T. M?kel? Heikki Kiviniemi Seppo Laitinen | 2003 | Diseases of the Colon & Rectum2003，，5： | 1 |
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