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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 3 | Neurospheres enriched in cancer stem like cells are highly effective in eliciting a den- dritic cell mediated immune response against malignant gliomas 显示文摘 | Serena P Pietro L P Daniela C | 2006 | Cancer Res2006，66，10： | 1 |
| 4 | Human Nutrition and Metabolism 显示文摘 | Charlotte A Welma O Serena S Alexandre L | 2004 | American Society for Nutri- tional Sciences2004，，： | 1 |
| 5 | Ouabain-inhibiting activity of aldosterone antagonists显示文摘 | Semplicini A Serena L Valle R | 1995 | Steroids1995，60，1： | 1 |
| 6 | the expanding universe of γδT lytuphocytes : subsets, generation and function 显示文摘 | Serena M Nadia C L M Girliana G | 2008 | Current Immuno Rev2008，4，4： | 1 |
| 7 | Colonization, succession, and nutrition of macrobenthic assemblages in a restored wetland at Tijuana Estuary, California显示文摘 | Serena M M Lisa A L Carolyn C | 2004 | Estuary Coast & Shelf Science2004，60，： | 1 |
| 8 | The empirical risk-return relation: A factor analysis approach显示文摘 | Sydney C L Serena N | 2007 | Journal of Financial Economics2007，83，1： | 1 |
| 9 | Ouabain-inhibiting activity of aldosterone antagonists显示文摘 | Semplicini A Serena L Valle R | 1995 | Steroids1995，60，1： | 1 |
| 10 | Ouabain--inhibiting activity of aldosterone antagonists 显示文摘 | Semplicini A Serena L Valle R | 1995 | Steroids1995，60，1： | 1 |
| 11 | Excess Sensi- tivity and Asymmetries in Consumption: An Em- pirical Investigation 显示文摘 | Garcia R Annamaria L Serena N | 1997 | Journal of Money Credit and Banking1997，29，2： | 1 |
| 12 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule一1 induction by advanced glycation end products显示文摘 | Giuseppina B Guido L Serena DT | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 13 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 14 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 15 | Spectrophotometric determination of binding constants between some aminocyclodextrins and nitrobenzene derivatives at various pH values显示文摘 | MEO P L FRANCESCA D A SERENA R | 2002 | Tetrahedron2002，58，： | 1 |
| 16 | The GLUT9 gene isassociated with serum uric acid levels in Sardinia and ChiantiCohorts 显示文摘 | Siguang L Serena S Andrea M | 2007 | PLoS One2007，11，3： | 1 |
| 17 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 18 | AFLP analysis as biomarker of exposure to organic and inorganic genotoxic substances in plant显示文摘 | Massimo L Fabrizio G Serena I | 2003 | Chemosphere2003，52，7： | 1 |
| 19 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products显示文摘 | Giuseppina B Guido L Serena D T | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 20 | Yeast dynamics during the fermentation of brined green olives treated in the field with kaolin and Bordeaux mixture to control the olive fruit fly显示文摘 | Serena Muccilli Cinzia Caggia Cinzia L | 2011 | International Journal of Food Microbiology2011，148，1： | 1 |
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