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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Development of an IL-6 inhibitor based on the functional analysis of routine IL-6 Ra显示文摘 | Miesinger M Y Serge H Stefan W | 2009 | Chem and Biol2009，16，7： | 1 |
| 3 | Cytochrome c oxidase defects of the human substantia nigra in normal aging显示文摘 | KYOKO I SERGE W PARVIZ M | 1996 | Neurobiol Aging1996，17，： | 1 |
| 4 | Simultaneous spectrophotometric determination of maltol, ethylmaltol, vaniUin and ethy vanillin in foods by multivariate calibration and art ificial neural networks 显示文摘 | Ni Y N Zhang G W Serge K | 2005 | Food Chemistry2005，89，3： | 1 |
| 5 | The neural underpin- nings of event-file management: evidence for stimulus-in- duced activation of and competition among stimulus-re- sponse bindings 显示文摘 | Simone Kuhn Andre W Keizer Lorenza S Colzato Serge A R B Rombouts Bernhard Hommel | 2011 | Journal of cognitive neuroscience2011，23，4： | 1 |
| 6 | Kineticanalysis of the thermal degradation of polystyrene- montmorillonitenanocomposite 显示文摘 | Serge Bourbigot Jeffrey W Gilman Charles A Wilkie | 2004 | Polymer Degradation and Stability2004，84，3： | 1 |
| 7 | Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis显示文摘BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths yearly.HBV is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’blood.Different regions of the world show a highly variable proportion of HCWs infected and/or immunized against HBV.Global data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV control.AIM To determine the worldwide prevalence of HBV serological markers among HCWs.METHODS In this systematic review and meta–analyses,we searched PubMed and Excerpta Medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs worldwide.We also manually searched for references of relevant articles.Four independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin M anti-HBc,and anti-HBs.Methodological quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in HCWs.Heterogeneity(I²)was assessed using theχ²test on Cochran’s Q statistic and H parameters.Heterogeneity’sources were explored through subgroup and metaregression analyses.This study is registered with PROSPERO,number CRD42019137144.RESULTS We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this meta-analysis.The pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),respectively.The pooled seroprevalences of total immunity against HBV and immunity acquired by natural HBV infection in HCWs were 56.6%(95%CI:48.7-63.4)and 9.2%(95%CI:6.8-11.8),respectively.HBV infection was more prevalent in HCWs in low-income countries,particularly in Africa.The highest immunization rates against HBV in HCWs were recorded in urban areas and in high-income countries including Europe,the Eastern Mediterranean and the Western Pacific.CONCLUSION New strategies are needed to improve awareness,training,screening,vaccination,post-exposure management and treatment of HBV infection in HCWs,and particularly in low-income regions. | Gadji Mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Chavely Gwladys Monamele Chris Andre Mbongue Mikangue Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K M Fokou Raoul Kenfack-Momo Dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean Joel Bigna Onana Boyomo Richard Njouom | 2021 | World Journal of Hepatology2021，13，9： | 1 |
| 8 | The deviation of bullets passing through windowpanes 显示文摘 | Jan D K Serge L W im V L Els De-mu ynck | 2002 | Fo- rensic Science International2002，125，： | 1 |
| 9 | Kinetic analysis of the thermal degradation of polystyrenemontmorillonite nanocomposite显示文摘 | Serge Bourbigot Jeffrey W Gilman Charles A Wilkie | 2004 | Polymer Degradation and Stability2004，84，： | 1 |
| 10 | Randomized, Double-Blind, Parallel-Group, 48-Week Study for Efficacy and Safety of a Higher-Dose Rivastigmine Patch (15 vs. 10 cm) in Alzheimer’s Disease显示文摘 | Cummings Jeffrey Froelich Lutz Black Sandra E Bakchine Serge Bellelli Giuseppe Molinuevo José L Kressig Reto W Downs Pamela Caputo Angelika Strohmaier Christine | 2012 | Dementia and Geriatric Cognitive Disorders2012，，5： | 1 |
| 11 | Cytochrome c oxidase defects of the human substantia nigra in normal aging显示文摘 | Kyoko I Serge W Parviz M | 1996 | Neurobiol Aging1996，17，： | 1 |
| 12 | Simultaneous spectrophotometric determination of maltol, ethyl maltol, vanillin and ethyl vanillin in foods by multivariate calibration and artificial neural networks显示文摘 | Ni Y N Zhang G W Serge K | 2005 | Food Chemistry2005，89，3： | 1 |
| 13 | IL -23 up- regulates IL- 10 and induces IL- 17 synthesis by polyclonally activated ha'i've T cells in human 显示文摘 | Serge V E Stanislas G Dominique D W | 2005 | Europe- an Journal of Immunology2005，35，2： | 1 |
| 14 | Kinetic analysis of the thermal degradation of polystyrene-montmorillonitenanocomposite显示文摘 | Serge Bourbigot Jeffrey W Gilman Charles A Wilkie | 2004 | Polymer Degradation and Stability2004，84，3： | 1 |
| 15 | Bringing an ecological view of change to Landsat: Based remote sensing显示文摘 | Kennedy R E Serge A Cohen W B | 2014 | Frontiers of Ecology and Environment2014，12，6： | 1 |
| 16 | Applicationof chemo- metrics methods for the simultaneous kineticspectro- photometric determination of aminoearb and carbaryl invegetahle and water samples显示文摘 | Ni Y N Xiao W Q Serge K | 2009 | Journal of Hazard- ous Materials2009，，168： | 1 |
| 17 | Preliminary ob- servations on the effects of holding temperature on reproduc- tive performance of female white sturgeon, Acipenser trans- montanus Richardson 显示文摘 | Molly A H W Joel P V E Serge I D | 1999 | Aquaculture1999，176，： | 1 |
| 18 | Inhibition of proteaso- mal glucocorticoid receptor degradation restores dexamethasone-me- diated stabilization of the blood-brain barrier after traumatic brain in- jury显示文摘 | Thal Serge C Schaible EV Neuhaus W | 2013 | Critical Care Med2013，41，： | 1 |
| 19 | Kinetic analysis of the thermal degradation of polystyrene-montmorillonite nanocomposite显示文摘 | Serge Bourbigot Jeffrey W Gilman Charles A Wilkie | 2004 | Polymer Degradation and Stability2004，84，： | 1 |
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