|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant显示文摘AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or cyclosporine.METHODS: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal dysfunction.RESULTS: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria. | José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan Serrano Jordi Muntané Francisco J Padillo Miguel A Gómez | 2015 | World Journal of Transplantation2015，5，1： | 6 |
| 3 | Land cover changes and fragmentation in mountain neotropical ecosystems of Oaxaca, Mexico under community forest management显示文摘Changes in land cover have a direct impact on forest ecosystem goods and services. In this study, changes in land cover in Sierra de Juarez–Oaxaca ecosystems were estimated using a consistent processing of Landsat images and OBIA methodology. Additionally, landscape analyses using FRAGSTAT were conducted. In 2014, Sierra de Juarez–Oaxaca was covered by approximately 84% of forests, mainly pine-oak and cloud forests. After extensive deforestation until 2001, this trend was reversed and the forest cover surface area in 2014 was slightly higher than in 1979. The comparison of the landscape structure of the forested and agricultural lands suggests an increase in habitat heterogeneity. However, interspersion and juxtaposition indices, showing the patch shape by patch area and perimeter, were similar throughout the study period(1979–2014). Social and economic drivers can explain this situation: namely, community organization, forest enterprises, payment for ecosystem services programs, and changes of agricultural activity. Communities in the Sierra of Oaxaca have reforested degraded lands, created community forest enterprises, and preserved the forest under conservation schemes like those proposed by the Mexican payment for ecosystem services programs. However, their sustainable management faces internal challenges and has become highly dependent on political and institutional decisions beyond their control. | Rafael M~a Navarro Cerrillo Dennis J.Esteves Vieira Susana Ochoa-Gaona Bernardus H.J.de Jong M~a del Mar Delgado Serrano | 2019 | Journal of Forestry Research2019，30，1： | 4 |
| 4 | Biogeochemistry inNeves Corvo mining region,Iberian Pyrite Belt,Portugal显示文摘 | Batista M J Abreu M M Serrano P M | 2007 | Journal of Geochemical Exploration2007，92，23： | 3 |
| 5 | A new regulatory motif in cell cycle control causing specific inhibition of cyclinD/CDK4显示文摘 | Serrano M Hannon Gj Beach D | | 0，，： | 2 |
| 6 | Synthesis and characterization of epoxidized styrene-butadiene block copolymer as templates for nanostructured thermosets显示文摘 | Serrano E Larranaga M Remiro P M | 2004 | Macromolecular chemistry and physics2004，205，7： | 1 |
| 7 | Effects of sample pre-treatment on the δ^13C and δ^18O values of living benthic foraminifera显示文摘 | Serrano O Serrano L Mateo M A | 2008 | Chemical Geology2008，257，： | 1 |
| 8 | The common biology of cancer and ageing显示文摘 | Finkel T Serrano M Blasco M | 2007 | Nature2007，448，7155： | 1 |
| 9 | Microsatellite based genetic diversity and population structure of the en-dangered Spanish Guadarrama goat breed显示文摘 | Serrano M Calvo J H Martínez M | 2009 | BMC Genetics2009，10，： | 1 |
| 10 | Confocal mi-croscopy study of phase morphology evolution in epoxy/polysiloxanethermosets显示文摘 | Cabanelas J C Serrano B Gonzalez M G | 2005 | Polymer2005，46，： | 1 |
| 11 | Detecting rich-club ordering in complex networks显示文摘 | Colizza V Flammini A Serrano M A | 2006 | Nature Physics2006，2，2： | 1 |
| 12 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4显示文摘 | Serrano M Hannon GT Beach D | 1993 | Nature1993，366，6： | 1 |
| 13 | Cancer: a lower bar for senescence 显示文摘 | Serrano M | 2010 | Nature2010，464，7287： | 1 |
| 14 | Bethesda criteria for microsatellite instability testing: impact on the detection of new cases of Lynch syn- drome显示文摘 | Serrano M Lage P Belga S | 2012 | Faro Cancer2012，1，4： | 1 |
| 15 | The role of polyamines in the improvement of shelf life of fruits 显示文摘 | Valero D Martinez-romero D Serrano M | 2002 | Trends Food Sci Teehnol2002，13，： | 1 |
| 16 | Psychometric characteristics of PIMS-compared to PDQ-39 and PDQL-to evaluate quality of life in Parkinson's disease patients: validation in Spanish (Ecuadorian style)显示文摘 | Serrano-Duenas M Serrano S | 2008 | Parkinsonism Relat Disord2008，14，2： | 1 |
| 17 | Glomerular filtration rate in evaluation of the effect of iodinated contrast media on renal function 显示文摘 | Becker J Babb J Serrano M | 2013 | A JR Am J Roentgenol2013，200，4： | 1 |
| 18 | The glass transition and interfacial layer instyrene-butadiene rubber containing silica nanofiller 显示文摘 | Arrighi V MeEwen I J Qian H Serrano P M B | 2003 | Polymer2003，44，： | 1 |
| 19 | The power and the promise of oncogene-induced senescence markers显示文摘 | Collado M Serrano M | 2006 | Nat Rev Cancer2006，6，6： | 1 |
| 20 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 显示文摘 | SERRANO M HANNON G J BEACH D | 2003 | Nature2003，366，6456： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员