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454篇 您的检索式:作者名="Sethi M"
    题名 作者 年代 出处 被引量
1Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition.Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar 2015World Journal of Gastroenterology2015,21,43:36
2The complexity of flowshop and jobshop scheduling显示文摘Garey M R Johnson D S Sethi R 1996Mathematies Operations Research1996,1,11:1
3The complexity of flowshop and jobshop scheduling显示文摘GAREY M R JOHNSON D S SETHI R 1976Math Oper Res1976,,1:1
4beta 2 - adrenergic receptor polymorphisms, asthma and COPD: two large population - based studies显示文摘Thomsen M Nordestgaard BG Sethi AA 2012Eur Respir J2012,39,:1
5Posterior vitreous detachment induced by microplasmin显示文摘Gandorfer A Rohleder M Sethi C 0,,02:1
6Accuracy of anterior intra-articular injection of the glenohumeral joint 显示文摘SETHI P M KINGSTON S ELATTRACHE N 2005Arthroscopy: The Journal of Arthroscopic Related Surgery2005,21,1:1
7Accuracy of anterior Intra-articalar injection of the glenohumeral joint, arthroscopy显示文摘Paul M Sethi MD 2005Journal of Arthroscopie and Related Surgery2005,1,:1
8Diagnosis of ventilator-associat-ed pneumonia in children in resource-limited setting:a comparative study of bronchoscopic and nonbronchoscopic methods 显示文摘Sachdev A Chugh K Sethi M 2010Pediatr Crit Care Med2010,11,2:1
9The complexity of flow shop and job shop scheduling显示文摘Garey M R Johnson D S Sethi R 1976Mathematics of Op- erations Research1976,1,2:1
10Evidence of chlamydial infectiori in infertile women with fallopian tube obstruction 显示文摘Sharma M Sethi S Daftari S 2003India J Pathol Microbiol2003,46,4:1
11Evidence of chlamydial infection in infertile women with fallopian tube obstruction显示文摘Sharma M Sethi S Daftari S 2003Indian J Pathol Microbiol2003,46,:1
12The complexity of flowshop and job shop scheduling显示文摘Garey M R Johnson D S Sethi R 1976Mathematics of Operations Research1976,1,2:1
13The complexity of flowshop and jobshop scheduling显示文摘Garey M R Johnson D S Sethi R R 1976Mathematics of Operations Research1976,1,:1
14Synthesis and antifungal activity of 2-hydroxy-l-naphthalaniline and its N-phenyl derivatives 显示文摘MANRAO M R SETHI R K SHARMA R C 1996J Indian Chem Soc1996,73,:1
15Channel coordination with a risk-neutral supplier and a downside-risk-averse retailer显示文摘Gan X H Sethi S P Yan H M 2005Production and Operations Management2005,14,1:1
16Posterior vitreous detachment induced by microplasmin 显示文摘Gandorfer A Rohleder M Sethi C 2004Invest Ophthalmol Vis Sci2004,45,2:1
17Linking homogenization and densification in W-Ni-Cu alloys through master sintering curve (MSC) concepts显示文摘SETHI G PARK S J JOHNSON J L GERMAN R M 2009Intemational Journal of Refractory Metals and Hard Materials2009,27,4:1
18Sequencing and scheduling in robotic cells: recent developments 显示文摘Dawande M W Geismar H N Sethi S P 2005Journal of Scheduling2005,8,5:1
19Retinoblastoma显示文摘Mehta M Sethi S Pushker N 0,,02:1
20Psychological care in trauma patients显示文摘Mohta M Sethi AK Tyagi A 0,,01:1
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