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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | The role of magnetic field in the transition to streaming ablation in wire arrays显示文摘 | Martin M R Seyler C E Greenly J B | 2010 | Phys Plasmas2010，17，05： | 1 |
| 3 | Functional problems and arthrofibrosis following total knee arthroplasty 显示文摘 | Seyler T M Marker D R Bhave A | 2007 | J Bone Joint Surg Am2007，89，3： | 1 |
| 4 | Community associ ated methicillin-resistant Staphylococcus aurez,~s 显示文摘 | Mertens R Seyler L Lacor P e* al | 2012 | Acta Clin Belg2012，67，4： | 1 |
| 5 | Iron isotope composition of the bulk waters and sediments from the Amazon River Basin显示文摘 | Franck Poitrasson Lucieth Cruz Vieira Patrick Seyler Giana Márcia dos Santos Pinheiro Daniel Santos Mulholland Marie-Paule Bonnet Jean-Michel Martinez Barbara Alcantara Lima Geraldo Resende Boaventura Jér?me Chmeleff Elton Luiz Dantas Jean-Loup Guyot Luiz | 2014 | Chemical Geology2014，，： | 1 |
| 6 | Functional problems and treatment solutions solution safter total hip arthroplas-ty显示文摘 | Bhave A Marker D R Seyler T M | 2007 | J Arthroplasty2007，22，2： | 1 |
| 7 | Surface replacement is comp-arable to primary total hip arthroplasty显示文摘 | McGrath M S Marker D R Seyler T M | 2009 | Clin Orthop Relat Res2009，，467： | 1 |
| 8 | The role of magnetic field in the transition to streaming ablation in wire arrays显示文摘 | Martin M R Seyler C E Greenly J B | 2010 | Phys Plas- mas2010，17，05： | 1 |
| 9 | Valley-polarized exciton dynamics in a 2D semiconductor heterostructure显示文摘 | Rivera P Seyler K L Yu H Y Schaibley J R Yan J Q Mandrus D G Yao W Xu X D | 2016 | Sci- ence2016，351，6274： | 1 |
| 10 | Do modern techniques improve core decompression outcomes for hip osteonecrosis显示文摘 | MARKER D R SEYLER T M ULRICH S D | 2008 | Clin Orthop Relat Res2008，466，5： | 1 |
| 11 | Treatment of early stage osteonecrosis of the femoral head显示文摘 | David R Thorsten M Seyler M | 2008 | J Bone Joint Surg Am2008，，904： | 1 |
| 12 | Opening discussion显示文摘 | Seyler R J | 1994 | Assignment of the Glass Transition1994，，： | 1 |
| 13 | Community associated methicillin-resistant Staphylococcus aureus 显示文摘 | Mertens R Seyler L Lacor P | 2012 | Acta Clin Belg2012，67，4： | 1 |
| 14 | On the perpendicular scale of electron phase-space holes显示文摘 | Franz J R Kintner P M Seyler C E | 2000 | Geophys Res Lett2000，27，： | 1 |
| 15 | Structural and genetic analysis of the BldB protein of Streptomyces coelicolor显示文摘 | Eccleston MR Ali A Seyler R | 2002 | Journal of Bacteriology2002，184，15： | 1 |
| 16 | Relaxation model for extended magnetohydrodynamicst comparison to magnetohydrodynamics for dense Z-pinches 显示文摘 | Seyler C E Martin M R | 2011 | Phys Plasmas2011，18，01： | 1 |
| 17 | Pulsatile subcutaneous nocturnal administration of GnRH by portableinfusion pump in hypogonadotropic hypogonadism: initiation of gonadotropin responsiveness显示文摘 | Jacobson R I Seyler L E Jr Tamborlane W V Jr | 1979 | J Clin Endocrinol Metab1979，49，4： | 1 |
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