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| 1 | Clinical and molecular features of young-onset colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression. | Veroushka Ballester Shahrooz Rashtak Lisa Boardman | 2016 | World Journal of Gastroenterology2016，22，5： | 9 |
| 2 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 3 | Thermodynamic Analysis of Liquefied Natural Gas(LNG)Production Cycle in APCI Process显示文摘The appropriate production of liquefied natural gas(LNG)with least consuming energy and maximum efficiency is quite important.In this paper,LNG production cycle by means of APCI Process has been studied.Energy equilibrium equations and exergy equilibrium equations of each equipment in the APCI cycle were established.The equipments are described using rigorous thermodynamics and no significant simplification is assumed.Taken some operating parameters as key parameters,influences of these parameters on coefficient of performance(COP)and exergy efficiency of the cascading cycle were analyzed.The results indicate that COP and exergy efficiency will be improved with the increasing of the inlet pressure of MR(mixed refrigerant)compressors,the decreasing of the NG and MR after precooling process,outlet pressure of turbine,inlet temperature of MR compressor and NG temperature after cooling in main cryogenic heat exchanger(MCHE).The COP and exergy efficiency of the APCI cycle will be above 2% and 40%,respectively,after optimizing the key parameters. | Shahrooz Abbasi Nezhad Bezhan Shabani Majid Soleimani | 2012 | Journal of Thermal Science2012，21，6： | 3 |
| 4 | Behavior and design of reinforced concrete, steel, and steel-concrete coupling beams显示文摘 | KENT A HARRIES M EERI BINGNIAN GONG BAHRAM M SHAHROOZ | 2000 | Earthquake Spectra2000，16，4： | 1 |
| 5 | Outrigger beam-wall connections I: component testing and development of design model 显示文摘 | SHAHROOZ B M DEASON J T TUNC G | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 6 | Destructivetesting of decommissioned concrete slab bridge 显示文摘 | Miller R A Aktan A E Shahrooz B M | 1994 | Journal of Structural Engineering1994，120，7： | 1 |
| 7 | Outrigger beam-wall connections 1I : subassembly testing and further modeling enhancements 显示文摘 | SHAHROOZ B M TUNC G DEASON J T | 2004 | Journal of Structural Engineering2004，130，2： | 1 |
| 8 | Concrete-steel composite cou- pling beams I: component testing显示文摘 | Gong B Shahrooz B M | 2001 | Journal of Structural Engineering2001，，6： | 1 |
| 9 | Concrete-steel composite cou- pling beams II: subassembly testing and design verification显示文摘 | Gong B Shahrooz B M | 2001 | Journal of Structural Engineering2001，，6： | 1 |
| 10 | DestructiveTesting of Decommissioned Concrete Slab Bridge显示文摘 | A E Aktan B M Shahrooz | 1994 | Journal of Structural Engineering1994，120，7： | 1 |
| 11 | Electromagnetic interference (EMI) reduction from printed circuit board (PCB) using electromagnetic bandgap structures显示文摘 | Shahrooz Shahparnia Omar M Ramahi | 2004 | IEEE Transaction on Electromagnetic Compatibility2004，46，4： | 1 |
| 12 | Destructive testing of decommissioned concrete slab bridge 显示文摘 | Miller R A Aktan A E Shahrooz B M | 1994 | Journal of Structural Engineering1994，120，7： | 1 |
| 13 | Destructive tes- ting of decommissioned concrete slab bridge 显示文摘 | Miller R A Aktan A E Shahrooz B - M | 1994 | Journal of Structural Engineering1994，120，7： | 1 |
| 14 | Large scale testing of a replaceable 'fuse' steel coupling beam显示文摘 | Patrick J Fortney Bahram M Shahrooz Gian A Rassati | 2007 | Journal of Structural Engineering2007，133，12： | 1 |
| 15 | Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines显示文摘 | Seyedeh Parinaz Akhlaghi Shahrooz Saremi Seyed Nasser Ostad Rassoul Dinarvand Fatemeh Atyabi | 2010 | Nanomedicine: Nanotechnology Biology and Medicine2010，，5： | 1 |
| 16 | Concrete-Steel Composite Coupling Beams. II: Subassembly Testing and Design Verification显示文摘 | Bingnian Gong Bahram M. Shahrooz | 2001 | Journal of Structural Engineering2001，，6： | 1 |
| 17 | Behavior and design of reinforced concrete, steel, and steel - concrete coupling beams 显示文摘 | Harries Kent A Gong Bingnian Shahrooz Bahram M | 2000 | Earthquake Spectra2000，16，4： | 1 |
| 18 | Destructive testing of decommissioned concrete slab bridge 显示文摘 | Miller R A Aktan A E Shahrooz B M | 1994 | Journal of Structural Engineering1994，120，7： | 1 |
| 19 | Concrete-Steel Composite Coupling Beams. I: Component Testing显示文摘 | Bingnian Gong Bahram M. Shahrooz | 2001 | Journal of Structural Engineering2001，，6： | 1 |
| 20 | Seismic design:ld performance of composite coupled walls 显示文摘 | Shahrooz B M Remmetter M E Qin Fei | 1993 | Journal of Structural Engineering1993，119，11： | 1 |
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