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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Gastric floating ma- trix tablets: Design and optimization using combination of pol- ymers显示文摘 | Shailesh T Laxmanbhai D Dasharath M | 2008 | Acta Pharrn2008，58，： | 1 |
| 3 | Analysis and Simulation of Five- phase Synchronous Reluctance Machines Including Third Harmonic of Air-gap MMF显示文摘 | Toliyat H A Shailesh P W Lipo T A | 1998 | IEEE Transactions on Industry Application1998，34，2： | 1 |
| 4 | Transfersomes: Avesicular carrier system for transdermal drug delivery 显示文摘 | Shailesh T Paijapati Charmi Q | 2011 | AJBPR2011，2，1： | 1 |
| 5 | Effect of nanco- A1203 particles on the corrosion behavior of alkyd based waterborne coatings显示文摘 | Shailesh K Dhoke T Jai Mangal Sinha A S Khanna | 2009 | J Coat Technol Res2009，6，3： | 1 |
| 6 | Formulation and performance study of low molecular weight, alkyd - based waterborne anticorrosive coating on mild steel显示文摘 | Shailesh Kewaldas Dhoke T J M Sinha A S Khanna | 2008 | Progress Organic Coatings2008，62，2： | 1 |
| 7 | Preparation and invitro evaluation of ethylcellulose coated egg albumin micro-spheres of diltiazem hydrochloride显示文摘 | Shailesh T Vipul P Girishbhai J | 2010 | J Young Pharm2010，2，1： | 1 |
| 8 | Mechanism(s) of turmeric-mediated protective effects against benzo (a) pyrenederived DNA adducts 显示文摘 | Rachana T Shailesh D | 2002 | Cancer Letters2002，175，6： | 1 |
| 9 | Regional alterations of brain biogenic amines and GABA/glutamate levels in rats following chronic lead exposure during neonatal development显示文摘 | Shailesh K Umar MV Desiraju T | 1990 | Arch Toxicol1990，64，： | 1 |
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