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| 1 | Irritable bowel syndrome in children:Current knowledge, challenges and opportunities显示文摘Irritable bowel syndrome(IBS) is a common and troublesome disorder in children with an increasing prevalence noted during the past two decades. It has a significant effect on the lives of affected children and their families and poses a significant burden on healthcare systems. Standard symptom-based criteria for diagnosis of pediatric IBS have changed several times during the past two decades and there are some differences in interpreting symptoms between different cultures. This has posed a problem when using them to diagnose IBS in clinical practice. A number of potential patho-physiological mechanisms have been described, but so far the exact underlying etiology of IBS is unclear. A few potential therapeutic modalities have been tested in children and only a small number of them have shown some benefit. In addition, most of the described patho-physiological mechanisms and treatment options are based on adult studies. These have surfaced as challenges when dealing with pediatric IBS and they need to be overcome for effective management of children with IBS. Recently suggested top-down and bottom-up models help integrating reported patho-physiological mechanisms and will provide an opportunity for better understanding of the diseases process. Treatment trials targeting single treatment modalities are unlikely to have clinically meaningful therapeutic effects on IBS with multiple integrating patho-physiologies. Trials focusing on multiple combined pharmacological and non-pharmacological therapies are likely to yield more benefit. In addition to treatment, in the future, attention should be paid for possible prevention strategies for IBS. | Niranga Manjuri Devanarayana Shaman Rajindrajith | 2018 | World Journal of Gastroenterology2018，24，21： | 14 |
| 2 | Childhood constipation as an emerging public health problem显示文摘Functional constipation(FC) is a significant health problem in children and contrary to common belief, has serious ramifications on the lives of children and their families. It is defined by the Rome criteria which encourage the use of multiple clinical features for diagnosis. FC in children has a high prevalence(0.7%-29%) worldwide, both in developed and developing countries. Biopsychosocial risk factors such as psychological stress, poor dietary habits, obesity and child maltreatment are commonly identified predisposing factors for FC. FC poses a significant healthcare burden on the already overstretched health budgets of many countries in terms of out-patient care, in-patient care, expenditure for investigations and prescriptions. Complications are common and range from minor psychological disturbances, to lower health-related quality of life. FC in children also has a significant impact on families. Many paediatric clinical trials have poor methodological quality, and drugs proved to be useful in adults, are not effective in relieving symptoms in children. A significant proportion of inadequately treated children have similar symptoms as adults. These factors show that constipation is an increasing public health problem across the world with a significant medical, social and economic impact. This article highlights the potential public health impact of FC and the possibility of overcoming this problem by concentrating on modifiable risk factors rather than expending resources on high cost investigations and therapeutic modalities. | Shaman Rajindrajith Niranga Manjuri Devanarayana Bonaventure Jayasiri Crispus Perera Marc Alexander Benninga | 2016 | World Journal of Gastroenterology2016，22，30： | 10 |
| 3 | Simulation of four respiratory viruses and inference of epidemiological parameters显示文摘While influenza has been simulated extensively to better understand its behavior and predict future outbreaks,most other respiratory viruses have seldom been simulated.In this study,we provide an overview of four common respiratory viral infections:respiratory syncytial virus(RSV),respiratory adenovirus,rhinovirus and parainfluenza,present specimen data collected 2004e2014,and simulate outbreaks in 19 overlapping regions in the United States.Pairing a compartmental model and data assimilation methods,we infer key epidemiological parameters governing transmission:the basic reproductive number R0 and length of infection D.RSV had been previously simulated,and our mean estimate of D and R0 of 5.2 days and 2.8,respectively,are within published clinical and modeling estimates.Among the four virus groupings,mean estimates of R0 range from 2.3 to 3.0,with a lower and upper quartile range of 2.0e2.8 and 2.6e3.2,respectively.As rapid PCR testing becomes more common,estimates of the observed virulence and duration of infection for these viruses could inform decision making by clinicians and officials for managing patient treatment and response. | Julia Reis Jeffrey Shaman | 2018 | Infectious Disease Modelling2018，3，1： | 6 |
| 4 | Non-genetic contributions of the sperm nucleus to embryonic development显示文摘从几个实验室的最近的数据提供了最新使肥沃的卵母细胞从为合适的胚胎的开发被要求的精子染色质继承 epigenetic 信号的证据。为这评论的目的,术语 epigenetic 被用来描述从精子房间被传给胚胎的分子的信息的所有类型。当在哺乳动物或为为哪个有证据,它可以那么做为合适的 embryogenesis 被要求,有已经被建立了的 epigenetic 信息的至少六种不同形式。这些是(i) DNA methylation;(ii ) 精子特定的 histones,(iii ) 另外的联系染色质的蛋白质;(iv ) perinuclear 膜蛋白质;(v) 精子出生的 RNA 并且,这评论的焦点;并且(vi ) 由精子的 DNA 环领域组织原子矩阵。当为有效授精和随后的胚胎开发作为必要部件为帮助繁殖技术为精子的操作和 cryopreservation 设计协议时,这些 epigenetic 信号应该被考虑。 | Yasuhiro Yamauchi Jeffrey A Shaman W Steven Ward | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 5 | Autonomic functions and gastric motility in children with functional abdominal pain disorders显示文摘BACKGROUND Abdominal pain-predominant functional gastrointestinal disorders(AP-FGIDs)are the most common cause of recurrent abdominal pain in children. Despite its high prevalence, the underlying pathophysiology of this condition is poorly understood.AIM To assess the role of gastric dysmotility and autonomic nervous system dysfunction in the pathophysiology of AP-FGIDs.METHODS One hundred children, fulfilling Rome III criteria for AP-FGIDs, and 50 healthy controls, aged 5 to 12 years, were recruited after obtaining parental consent. All patients were investigated for underlying organic disorders. Gastric motility and cardiovascular autonomic functions were assessed using validated non-invasive techniques.RESULTS The main gastric motility parameters assessed(gastric emptying rate [45.7 vs 59.6 in controls], amplitude [48.7 vs 58.2], frequency of antral contractions [8.3 vs 9.4],and antral motility index [4.1 vs 6.4]) were significantly lower in children with AP-FGIDs(P < 0.05). The post-prandial antral dilatation at 1 min after the test meal significantly correlated with the severity of abdominal pain(P < 0.05).Assessment of autonomic functions in AP-FGID patients showed neither a significant difference compared to the control group, nor a correlation with gastric motility abnormalities(P > 0.05). The duration of pain episodes negatively correlated with the parasympathetic tone(maladaptive parasympathetic tone)(P< 0.05).CONCLUSION Children with AP-FGIDs have abnormal gastric motility but normal cardiovascular autonomic functions. There is no relationship between abnormal gastric motility and autonomic functions. The pathogenesis of AP-FGIDs is not related to cardiovascular autonomic dysfunction. | Amaranath Karunanayake Shaman Rajindrajith Hitanadura Asita de Silva Sampath Gunawardena Niranga Manjuri Devanarayana | 2019 | World Journal of Gastroenterology2019，25，1： | 3 |
| 6 | Influence of non‐alcoholic fatty liver disease on the development of diabetes mellitus显示文摘 | Anuradhani Kasturiratne Sanjaya Weerasinghe Anuradha S Dassanayake Shaman Rajindrajith Arjuna P Silva Norihiro Kato A Rajitha Wickremasinghe H Janaka Silva | 2012 | J Gastroenterol Hepatol2012，，1： | 2 |
| 7 | Association between functional abdominal pain disorders and asthma in adolescents: A cross-sectional study显示文摘AIM To find the association between asthma and different types of functional abdominal pain disorders(FAPDs) among teenagers. METHOD A cross-sectional study was conducted among 13 to 15-year-old children from six randomly selected schools in Anuradhapura district of Sri Lanka. Data were collected using translated and validated selfadministered questionnaires(Rome Ⅲ questionnaire, International Study on Asthma and Allergies in Childhood questionnaire, and Pediatric Quality of Life Inventory 4.0) and administered under an examination setting after obtaining parental consent and assent.RESULTS Of the 1101 children included in the analysis, 157(14.3%) had asthma and 101(9.2%) had at least one FAPDs. Of children with asthma, 19.1% had at least one type of FAPDs. Prevalence rates of functional abdominal pain(FAP)(8.9% vs 3.3% in nonasthmatics), functional dyspepsia(FD)(2.5% vs 0.7%), and abdominal migraine(AM)(3.2% vs 0.4%) were higher in those with asthma(P < 0.05, multiple logistic regression analysis), but not in those with irritable bowel syndrome(4.5% vs 3.1%, P = 0.2). Severe abdominal pain(10.8% vs 4.6%), bloating(16.6% vs 9.6%), nausea(6.4% vs 2.9%), and anorexia(24.2% vs 16.2%) were more prevalent among asthmatics(P < 0.05). Lower gastrointestinal symptoms did not show a significant difference. Scores obtained for health related quality of life(HRQoL) were lower in those with asthma and FAPDs(P < 0.05, unpaired t-test).CONCLUSION Asthma is associated with three different types of FAPDs, namely, FD, AM, and FAP. HRQoL is significantly impaired in teenagers with asthma and FAPDs. | Manori Vijaya Kumari Niranga Manjuri Devanarayana Lakmali Amarasiri Shaman Rajindrajith | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 8 | Topoisomerase II- mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes显示文摘 | Yamauchi Y Shaman JA Ward WS | 2007 | Biol Reprod2007，76，4： | 1 |
| 9 | Du- al-mode microstrip open-loop resonators and filters 显示文摘 | Hong Jiansheng Hussein Shaman Young-Hoon Chun | 2007 | IEEE Transactions Microwave Theory and Techniques2007，55，8： | 1 |
| 10 | Derivatization with 4-chlo- ro-7-nitro-2,1,3-benzoxadiazolc for the spectrophotomet- fie and differential pulse polarographic determination of acetylcysteine and captopfil 显示文摘 | Haggag R Belal S ShaMan R | 2008 | Science Pharmacy2008，，76： | 1 |
| 11 | Behavioral portfolio theory 显示文摘 | Hersh Shefrin Meir Shaman | 2000 | Journal of Financial and Quantitative Analysis2000，35，2： | 1 |
| 12 | Hyperphosphatemia Management in Patients with Chronic Kidney Disease显示文摘 | Shaman AM Kowalski SR | 2016 | Saudi Pharm J2016，24，4： | 1 |
| 13 | Antecedents of Organizational Slack显示文摘 | SHAMAN M P etc al | 1988 | Academy of Management Review1988，13，4： | 1 |
| 14 | Topoisomerase II-mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes 显示文摘 | Yamanchi Y Shaman JA Ward WS | 2007 | Biol Repmd2007，76，4： | 1 |
| 15 | Ultra-wideband (UWB) bandpass filter with embedded band notch structures 显示文摘 | SHAMAN H HONG J S | 2007 | Microwave and Wireless Components Letters2007，17，3： | 1 |
| 16 | Findings of a Ber- lin Questionnaire survey: comparison between patients seen in an asthma clinic versus internal medicine clinic 显示文摘 | Auckley D Moallem M Shaman Z | 2008 | Sleep Med2008，9，： | 1 |
| 17 | The Structure and Governance of Venture-Capital Organizations显示文摘 | Shaman W A | 1999 | Journal of Financial Economics1999，，27： | 1 |
| 18 | Laparoscopic cholecys- tectomy in cirrhotics: aprospective randomized study comparing the con- ventional diathermy and the harmonic scalpel for gallbladder dissection显示文摘 | Bessa SS Abdel-Razek AH Shaman MA | 2011 | J laparoendosc Adv Surg Tech A2011，21，1： | 1 |
| 19 | Toward defining and abolishing the Bona Fide Occupational Qualification based on class status显示文摘 | Shaman Jeffrey M | 1971 | Labor Law Journal1971，22，6： | 1 |
| 20 | Diastolic stress echocargiography:hemedynamic validation and clinical significance of estimation of ventricular filling pressure with exercise显示文摘 | Burgess MI Jenkins C Shaman JE | | Journal of the American College of Cardiology0，，： | 1 |
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