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| 1 | Intervention effect of Zhuangfang Rugan Huaxian Granules on CCl_(4)compound factor‑induced liver fibrosis rat model and its effect on the expression ofα‑SMA and E‑Cadherin显示文摘Objective:To study the intervention effect of Zhuangfang Soft Liver and Fibrous Granules on CCl_(4)compound factor-induced liver fibrosis rat model and its effect onα-SMA and E-Cadherin protein expression.Methods:Forty-eight male Wistar rats were randomly divided into a blank group,a pathological model group and a group of 16 rats in each group.The rats in the pathological model group and the pellet group were injected subcutaneously with 40%carbon tetrachloride(CCl_(4))oil combined with peanut oil to establish an animal model of rat liver fibrosis,and the pellets were administered by gavage three times a week for 8 weeks from the 5th week.The expression of oxidative stress oxidase dismutase(SOD)and malondialdehyde(MDA)was detected by enzyme-linked immunoassay(ELISA),and the expression ofα-smooth muscle actin(α-SMA)and E-calmodulin(E-Cadherin)was detected by RT-PCR andWestern Blot.expression.Results:Compared with the blank group,the serum ALT and AST levels of the rats in the pathological model group were significantly increased,and the serum ALT and AST levels of the rats in the soft liver and fibrous pellet group were significantly decreased(P<0.001).In the pathological model group,the lobular structure of liver tissue was mutilated and numerous liver fibrous tissues were abnormally proliferated,and the collagen fibers formed by the proliferation were confluent into dense fibrous intervals,thus turning into pseudolobular structure,and a large number of fatty degenerated hepatocytes of different shapes and sizes appeared inside the pseudolobular structure,and the diffuse infiltration of inflammatory cells was significant.Compared with the pathological model group,the degree of destruction of hepatic lobular structure was significantly reduced in the LBP group,and there were different degrees of proliferation of collagen fibrous tissue concentrated in the area from the central vein to the confluent area,and the fibrous septum was relatively loose,with a small amount of inflammatory cell infiltration,and the degree of infiltration was reduced compared with the pathological model group.Compared with the pathological model group,the SOD level was significantly higher in the group of liver softener and fibrous pellets compared with the pathological model group and the blank group(P<0.001),the MDA level was significantly lower in the group of liver softener and fibrous pellets compared with the pathological model group(P<0.001),the expression level ofα-SMA was significantly lower in the group of liver softener and fibrous pellets(P<0.001),and the expression level of E-Cadherin was significantly higher in the group of liver softener and fibrous pellets(P<0.001).Conclusion:Soft Liver Fibro Pellets can effectively inhibit liver fibrous tissue proliferation and reduce the serum ALT and AST levels in rats with CCl_(4)combined with peanut oil compound solution induced liver fibrosis,and its anti-liver fibrosis mechanism may be through protecting liver function,reducing the level of oxidative stress,down-regulating the expression ofα-SMA protein,up-regulating the expression of E-cadherin protein,and inhibiting epithelial-mesenchymal transition epithelial mesenchymal transformation(EMT)and thus exerting therapeutic effects on CCl_(4)compound-induced hepatic fibrosis in rats. | ZHANG Wen‑fu WU Shan‑shan DAI Ming LV Jian‑lin HUANG Jing‑jing LI Xiao‑long WANG Zhen‑chang | 2023 | Journal of Hainan Medical University2023，29，5： | 0 |
| 2 | Characterization of FEEWAVE,a low‑power waveform digitizer ASIC with 15‑ps time resolution显示文摘Purpose FEEWAVE is a chip with a waveform digitizer based on a switched capacitor array(SCA).A SCA uses capacitor arrays to store waveforms and exhibits low-power consumption and high time resolution performance.However,the limitations of the chip manufacturing process induce sampling interval and digitization deviations between different cells,which affects the performance of the chip.Methods Calibration was performed on the SCA sampling part on the FEEWAVE chip to obtain more accurate digitized output and time intervals between the sampling cells.Experiments were carried out according to the proposed amplitude and time calibration methods,and the time resolution of the chip was further improved by a fitting algorithm.Results and conclusion Through the calibration algorithm,the time resolution of the SCA sampling part of the chip reached 9.0 ps after calibration.In the self-test of the electronics time performance,the time measurement after leading-edge fitting and calibration was approximately 12.3 ps.In the joint test with silicon photomultiplier detectors,the time resolution of the SCA part was low and comparable to the resolution of the oscilloscope after calibration algorithm and waveform fitting. | Yu‑sheng Wang Jia‑yi Ren Wei Wei Jie Zhang Pei‑ran Ye Xiao‑shan Jiang Zheng Wang | 2023 | Radiation Detection Technology and Methods2023，7，3： | 0 |
| 3 | Rainfall amount determines annual herb controls over soil seed bank and its similarity with vegetation in the Tengger Desert显示文摘Background:Soil seed banks may offer great potential for maintaining and restoring desert ecosystems that have been degraded by climate change and anthropogenic disturbance.However,few studies have explored the year‑to‑year dynamics in the species composition(richness and abundance)of these desert soil seed banks.Thus,we conducted a 4‑year study to assess the effects of environmental factors(meteorology and microtopography)and aboveground vegetation on the soil seed bank of the Tengger Desert,China.Results:We found the seed bank was dominated by annual herb species both in species richness and abundance.More rainfall in the growing season increased the number of seeds in the soil seed bank,and quadrat micro‑elevation had a negative effect on soil seed bank size.The species composition in the seed bank had significantly larger between‑year similarity than that in the aboveground vegetation due to the dominance of annual herb species.For different life forms,the species composition of annual herbs showed distinctly larger temporal similarity between the aboveground vegetation and the seed bank compared with perennial herbs and shrubs.Conclusions:Our findings highlight that the combined effects of environmental factors and plant life forms deter‑mine the species composition(especially the abundance)of soil seed banks in deserts.However,if degraded desert ecosystems are left to regenerate naturally,the lack of shrub and perennial herb seeds could crucially limit their restoration.Human intervention and management may have to be applied to enhance the seed abundance of perennial lifeforms in degraded deserts. | Ya‑Fei Shi Zeng‑Ru Wang Bing‑Xin Xu Jian‑Qiang Huo Rui Hu Yang Zhao Zhi‑Shan Zhang | 2022 | Ecological Processes2022，11，1： | 0 |
| 4 | 同步放化疗联合每周多西他赛与顺铂治疗局部晚期鼻咽癌的比较:一项倾向性评分匹配分析显示文摘背景与目的基于多西他赛的同步放化疗(concurrent chemoradiotherapy,CCRT)治疗头颈部肿瘤疗效显著且毒性可控。CCRT联合顺铂和/或5-氟尿嘧啶治疗局部晚期和转移性/复发性鼻咽癌(nasopharyngeal carcinoma,NPC)疗效确切。但是,CCRT联合多西他赛治疗局部晚期NPC尚无明确报道。本研究旨在比较CCRT联合每周多西他赛与3周1次顺铂治疗局部晚期NPC的疗效及毒性。方法评估2010年1月至2014年12月新确诊为局部晚期NPC患者的临床资料,患者均接受了CCRT联合每周1次多西他赛(15mg/m^2)或3周1次顺铂(80–100 mg/m2)的治疗。为平衡基线特征,进行了1∶1的特征评分匹配。比较两组间的不良事件和生存期。结果本研究共纳入962例患者,对其中448例患者进行了匹配并认定为匹配队列。整体队列的平均随访持续时间为48个月。在整体队列[风险比(hazard ratio,HR)=0.37,95%置信区间(confidence interval,CI):0.19–0.72,P=0.030]和匹配队列(HR=0.33,95%CI:0.14–0.79,P=0.023)两组中,接受多西他赛治疗患者的3年淋巴结无复发生存率均显著提高。然而,在2个队列中,总生存期、无局部复发生存期,无远端转移生存期均无显著差异。多西他赛组中患者的3级放射性皮炎(6.7%vs.1.8%,P=0.001)、黏膜炎(74.5%vs.37.9%,P<0.001)的发生率显著增高,而顺铂组患者多发任意级别的肾损伤(1.8%vs.15.1%,P<0.001)、呕吐(18.8%vs.88.3%,P<0.001)和ALT升高(19.2%vs.31.3%,P=0.027)及白细胞减少(2.2%vs.11.6%,P<0.001)。结论CCRT联合每周低剂量多西他赛对局部NPC患者是一种有效且可耐受的治疗方案。尤其是针对治疗前EBV DNA水平较低的患者,该方案可主要通过提高控制局部淋巴结转移进而使患者获得良好的生存获益。 | Jun‑Fang Liao Qun Zhang Xiao‑Jing Du Mei Lan Shan Liu Yun‑Fei Xia Xiu‑Yu Cai Wei Luo | 2019 | 癌症2019，38，9： | 2 |
| 5 | A gross deletion of the PAX3 gene in a large Chinese family with Waardenburg syndrome type Ⅰ显示文摘Waardenburg syndrome(WS)is an autosomal-dominant neurocristopathy characterized by sensorineural hearing loss(SNHL)and pigmentary abnormalities of the iris,hair,and skin.It is responsible for approximately 3%of congenital hearing loss[1].WS is thought to be fully penetrant when considering at least one clinical feature,but the penetrance of each feature is not complete[2].Four types of WS have been classifed based on the clinical manifestations.WS1 is one of the most common forms of WS.To confrm the diagnosis of WS1,at least two major or one major plus two minors of the Waardenburg consortium criteria must be present.In brief,major criteria include congenital sensorineural hearing loss,pigmentary disturbances of the iris,hair hypopigmentation,dystopia canthorum(average W index of afected family members is greater than 1.95)and afected frst-degree relatives.Minor criteria include skin hypopigmentation,synophyrys or medial eyebrow fare,broad and high nasal root,hypoplasia of alae nasi,and premature graying of hair[3].High phenotypic heterogeneity has been observed in WS1,even in the same family[4]. | Shu‑Zhi Yang Lei Hou Xin Qi Guo‑Jian Wang Sha‑Sha Huang Shan‑Shan Zhang Bang‑Qing Huang Ying Yang Bei‑Cheng Li Shuo Liu Pu Dai Yu Su | 2023 | World Journal of Pediatrics2023，19，12： | 0 |
| 6 | The rapid and efficient strategy for SARS-CoV-2 Omicron transmission control: analysis of outbreaks at the city level显示文摘Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. Hence, control measures are continuously being optimized to guard against large-scale coronavirus disease 2019 (COVID-19) outbreaks. This study aimed to explore the relationship between the intensity of control measures in response to different SARS-CoV-2 variants and the degree of outbreak control at city level.Methods: A retrospective study was conducted in 49 cities with COVID-19 outbreaks between January 2020 and June 2022. Epidemiological data on COVID-19 were extracted from the National Health Commission, People’s Republic of China, and the population flow data were sourced from the Baidu migration data provided by the Baidu platform. Outbreak control was quantified by calculating the degree of infection growth and the time-varying reproduction number (Rt). The intensity of the outbreak response was quantified by calculating the reduction in population mobility during the outbreak period. Correlation and regression analyses of the intensity of the control measures and the degree of outbreak control for the Omicron variant and non-Omicron mutants were conducted, respectively.Results: Overall, 65 outbreaks occurred in 49 cities in China from January 2020 to June 2022. Of them, 66.2% were Omicron outbreaks and 33.8% were non-Omicron outbreaks. The intensity of the control measures was positively correlated with the degree of outbreak control (r = 0.351,P = 0.03). The degree of reduction in population mobility was negatively correlated with the R_(t) value (r = - 0.612,P < 0.01). Therefore, under the same control measure intensity, the number of new daily Omicron infections was 6.04 times higher than those attributed to non-Omicron variants, and theRt value of Omicron outbreaks was 2.6 times higher than that of non-Omicron variants. In addition, the duration of non-Omicron variant outbreaks was shorter than that of the outbreaks caused by the Omicron variant (23.0 ± 10.7, 32.9 ± 16.3,t = 2.243,P = 0.031).Conclusions: Greater intensity of control measures was associated with more effective outbreak control. Thus, in response to the Omicron variant, the management to restrict population movement should be used to control its spread quickly, especially in the case of community transmission occurs widely. Faster than is needed for non-Omicron variants, and decisive control measures should be imposed and dynamically adjusted in accordance with the evolving epidemic situation. | Jin‑Xin Zheng Shan Lv Li‑Guang Tian Zhao‑Yu Guo Pei‑Yong Zheng Yue‑Lai Chen Shi‑Yang Guan Wei‑Ming Wang Shun‑Xian Zhang | 2022 | Infectious Diseases of Poverty2022，11，6： | 0 |
| 7 | Quality of life of hospitalized patients after lung cancer operation and analysis of influencing factors显示文摘Objective:To explore the current status and influencing factors of quality of life in patients with lung cancer after surgery in a tertiary hospital in Hainan province.Methods:To investigate the influencing factors of quality of life of lung cancer patients after surgery in a tertiary hospital in Hainan province by cross‑sectional survey method.Results:The scores of insomnia,appetite loss,constipation and pain in 186 lung cancer patients after surgery in a tertiary hospital in Hainan Province were significantly higher than the reference value.Multiple linear regression analysis showed that older patients(>60 years)had lower scores in physical function domain(β=-0.193),and female patients had more appetite loss symptoms(β=0.245).Compared with other minority ethnic groups,Han ethnic group had lower scores in role function domain(β=0.179),more severe fatigue symptoms(β=-0.162),and higher general health level(β=0.166).Patients with employee medical insurance had lower scores of emotional function(β=0.194),cognitive function(β=0.281),the lowest score in social function(β=0.188),and severe pain in other parts(β=-0.227).Smokers had less cough symptoms(β=0.175)and more arm and shoulder pain symptoms(β=-0.21)than non‑smokers.Patients with secondhand smoke exposure had lower cognitive function scores(β=-0.158)and more obvious symptoms of oral ulcer(β=0.185).Patients who drank alcohol frequently(drinking frequency>1 time/day)had more severe cough symptoms(β=0.27).Patients with small number of children(0‑1)had milder cough symptoms(β=0.178).Patients who did not understand the disease had obvious symptoms of arm and shoulder pain(β=0.151).Patients with early pathological stage(stageⅠ‑Ⅱ)had more severe shortness of breath(β=-0.159)and pain(β=-0.181).The symptoms of appetite loss were more obvious in patients living in cities(β=0.192).The symptoms of peripheral neuropathy were more obvious(β=0.174).Patients who often consumed pickulated food had severe pain symptoms(β=-0.219),and pain in other parts was obvious(β=-0.149).Male patients had obvious alopecia symptoms(β=-0.306).Conclusion:Age,ethnicity,residence,type of medical insurance,number of children,pathological stage of lung cancer,smoking,second‑hand smoke exposure,alcohol consumption,and frequent consumption of pickled food were related to the quality of life of lung cancer patients in hospital after surgery.Medical staff and family members should pay attention to the emotional communication of patients during the treatment of lung cancer patients in hospital after surgery.Patients should avoid exposure to smoking,alcohol and second‑hand smoke,and reduce consumption of pickled food. | HU Yi‑fan HUANG Xiu‑ming XIAO Sha ZHOU Jing WANG Shuo‑min WU Qi‑sheng ZHOU Bing‑xian FAN Shi‑heng FAN Ya‑yan CHEN Xian‑shan ZHANG Jing | 2023 | Journal of Hainan Medical University2023，29，12： | 0 |
| 8 | Interaction of radiation-induced defects with tungsten grain boundaries at across scales: a short review显示文摘As promising candidates for plasma-facing materials,tungsten-based materials suffer the irradiation of high-energy neutrons in addition to the hydrogen isotopes and helium irradiation and the high-thermal flux.Radiation-produced defects,e.g.self-interstitial atoms(SIAs)and vacancies(Vs),can induce the hardening and embrittlement of tungsten,meanwhile enhancing the retention of hydrogen isotopes and helium in tungsten.Reducing the grain size of materials to introduce a high density of defect sinks,e.g.,grain boundaries(GBs)prevalent in nano-/ultrafine-crystalline materials,was demonstrated to be an effective approach for mitigating irradiation damage in tungsten.In this paper,we reviewed the theoretical advances in exploring radiation-resistance of nano-structured tungsten at across scales.It was concentrated on the results of molecular dynamics,molecular statics,and the object kinetic Monte Carlo simulations on the fundamental interaction of the radiation-created Vs and SIAs with the GB.These mechanisms include GB-promoted V/SIA migration and SIA-V recombination,interstitial-emission induced annihilation,coupling of the V migration close to the GB with the SIA motion within the GB,and interstitial reflection by the locally dense GB structure.We proposed the remaining scientific issues on the defect-GB interactions at across scales and their relation to experimental observations.We prospected the possible trends for simulating the radiation damage accumulation and healing processes in nano-structured tungsten in terms of the development of the across-scale computational techniques and efficiency of the GB-enhanced tolerance of tungsten to irradiation under complex in-service conditions. | Xiang‑Yan Li Yan‑Ge Zhang Yi‑Chun Xu Xue‑Bang Wu Xiang‑Shan Kong Xian‑Ping Wang Qian‑Feng Fang Chang‑Song Liu | 2020 | Tungsten2020，2，1： | 0 |
| 9 | Multigenerational birth cohort study in China:importance,necessity and beyond显示文摘A birth cohort study is an epidemiological study that enrolls a group of people who were born during a specifc period of time and follows up with them from the prenatal period to adulthood and even old age.The establishment of a birth cohort study enables the exploration of the etiology of diseases and enriches the understanding and awareness of health status among the reproductive population.Additionally,it provides evidence-based support for the launch of public health policies and programs and thus practically promotes the health care of women and children,facilitating the early prevention of disease in childhood and adulthood[1]. | Sai‑Li Ni Wei He Jia‑Kai Zhang Fei Yang Guan‑Nan Bai Die Li Wei‑Ze Xu Jia‑Bin Li Qiang Shu Shan‑Kuan Zhu | 2023 | World Journal of Pediatrics2023，19，5： | 0 |
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