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| 1 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 2 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 3 | SPACECRAFT DOCKING SIMULATION USING HARDWARE-IN-THE-LOOP SIMULATOR WITH STEWART PLATFORM显示文摘A ground-based hardware-in-the-loop (HIL) simulation system with hydraulically drivenStewart platform for spacecraft docking simulation is presented. The system is used for simulatingdocking process of the on-orbit spacecraft. Principle and structure of the six-degree-of-freedom simu-lation system are introduced. The docking process dynamic of the vehicles is modeled. Experimentresults and mathematical simulation data are compared to validating the simulation system. The com-parisons of the results prove that the simulation system proposed can effectively simulate the on-orbitdocking process of the spacecraft. | Huang Qitao Jiang Hongzhou Zhang Shangying Han Junwei | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 12 |
| 4 | Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells显示文摘 | Yan Zhang Si Wang Xiuxia Wang Shangying Liao Yujian Wu Chunsheng Han | 2012 | Cell Research2012，22，4： | 10 |
| 5 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 6 | Kinetics and mechanisms of p-nitrophenol biodegradation by Pseudomonas aeruginosa HS-D38显示文摘The kinetics and mechanisms of p-nitrophenol(PNP)biodegradation by Pseudomonas aeruginosa HS-D38 were investigated. PNP could be used by HS-D38 strain as the sole carbon,nitrogen and energy sources,and PNP was mineralized at the maximum concentration of 500 mg/L within 24 h in an mineral salt medium(MSM).The analytical results indicated that the biodegradation of PNP fit the first order kinetics model.The rate constant kPNP is 2.039×10-2/h in MSM medium,KPNP+N is 3.603×10-2/h with the addition of ammonium chloride and KPNP+C is 9.74×10-3/h with additional glucose.The addition of ammonium chloride increased the degradation of PNP.On the contrary,the addition of glucose inhibited and delayed the biodegradation of PNP.Chemical analysis results by thin-layer chromatography(TLC),UV-Vis spectroscopy and gas chromatography(GC)techniques suggested that PNP was converted to hydroquinone(HQ)and further degraded via 1,2,4-benzenetriol(1,2,4-BT)pathway. | ZHENG Yongliang LIU Deli LIU Shiwang XU Shangying YUAN Yongze XIONG Li | 2009 | Journal of Environmental Sciences2009，21，9： | 6 |
| 7 | Physicochemical properties,antimicrobial activity and oil release of fish gelatin films incorporated with cinnamon essential oil显示文摘Fish skin gelatin films incorporated with various concentrations of cinnamon essential oil(CEO)were prepared and characterized.The results showed that tensile strength(TS),elongation at break(EAB),and water content(WC)of the gelatin based film decreased with the increasing concentrations of CEO,but water vapor permeability(WVP)increased.Addition of CEO improved light barrier property of the film.The Scanning electron microscope(SEM)showed that the heterogeneous surface and porous formation appeared in gelatin-CEO films.Fourier transform infrared spectroscopy analyses(FTIR-ATR)spectra indicated the interactions existed between gelatin and CEO.The gelatin-CEO films exhibited good inhibitory effects against the tested microorganisms(Escherichia coli,Staphylococcus aureus,Aspergillus niger,Rhizopus oryzae,and Paecilomyces varioti)and their antifungal activity seemed to be more effective than the resistance to bacterial growth.In vitro release studies showed an initial burst effect of CEO release and that subsequently slowed down at 40℃,but the initial burst release was not obvious at 4℃.The obtained results suggested that incorporation of CEO as a natural antimicrobial agent into gelatin film has potential for developing as active food packaging. | Jiulin Wu Xinyu Sun Xiaoban Guo Shangying Ge Qiqing Zhang | 2017 | Aquaculture and Fisheries2017，2，4： | 4 |
| 8 | Synthesis and Characterization of Niobium-doped TiO_2 Nanotube Arrays by Anodization of Ti-20Nb Alloys显示文摘Well crystallized niobium-doped TiO_2 nanotube arrays(TiNbO-NT) were successfully synthesized via the anodization of titanium/niobium alloy sheets,followed with a heat treatment at 550 C for 2 h.Morphology analysis results demonstrated that both the titanium/niobium alloy microstructure and the dissolution strength of electrolyte played major roles in the formation of nanotube structure.A single-phase microstructure was more favorable to the formation of uniform nanotube arrays,while modulating the dissolution strength of electrolyte was required to obtain nanotube arrays from the alloys with multi-phase microstructures.X-ray diffraction(XRD) and X-ray photoelectron(XPS) analysis results clearly demonstrated that niobium dopants(Nb 5+) were successfully doped into TiO_2 anatase lattice by substituting Ti 4+ in this approach. | Zhengchao Xu Qi Li Shian Gao Jianku Shangi | 2012 | Journal of Materials Science & Technology2012，28，10： | 4 |
| 9 | Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase显示文摘 | Hong Nian Wei Zhang Hexin Shi Qingzhen Zhao Qi Xie Shangying Liao Yan Zhang Zhuqiang Zhang Chen Wang Chunsheng Han | 2008 | Cell Research2008，18，7： | 2 |
| 10 | Pickering emulsions stabilized solely by layered double hydroxides particles: The effect of salt on emulsion formation and stability 显示文摘 | Yang Fei Liu Shangying Xu Jian | 2006 | Journal of Colloid and Interface Science2006，302，1： | 1 |
| 11 | Value of multi-quadrants biopsy:Pooled analysis of 11 population-based cervical cancer screening studies显示文摘Objective:The accuracy of colposcopy-guided biopsy is key to the success of colposcopic triage in cervical cancer screening programs.However,there is no widely adopted biopsy guideline up to date.Our study aimed to determine whether multi-quadrants biopsy improves the yield of cervical lesions.Methods:Eleven population-based cervical cancer screening studies were conducted in China.Cytology,highrisk human papillomavirus(hrHPV)testing and visual inspection were performed for primary screening.Females positive on one or more tests were referred for colposcopy and biopsy.The proportion of detected cervical intraepithelial neoplasia(CIN)2+and yields by quadrant lesion-targeted biopsy or 4-quadrant random biopsy were compared.Results:Among 4,923 females included,1,606 had quadrant lesion-targeted biopsy,and 3,317 had 4-quadrant random biopsy.The cumulative CIN2+yield increased from 0.10 for only one quadrant-targeted biopsy to 0.21,0.34,and 0.58 for at most two,three and four quadrants targeted biopsies.Among hrHPV positive females with high-grade squamous intraepithelial lesion(HSIL)+cytology,the cumulative CIN2+yield of a second targeted biopsy in another quadrant was significantly increased(P<0.05).Among hrHPV-negative females,the yield of 4-quadrant random biopsies was 0.005,and the yield by lesion-targeted biopsies was 0.017.For hrHPV positive females who had 4-quadrant random biopsy,the additional CIN2+yield for HSIL+,low-grade squamous intraepithelial lesion(LSIL)cytology,or abnormal visual inspection via acetic acid and Lugol’s iodine(VIA/VILI)were 0.46,0.11,0.14.Conclusions:A 4-quadrant random biopsy is recommended only for hrHPV positive females with HSIL cytology,and is acceptable if hrHPV positive with LSIL cytology or with abnormal VIA/VILI.Our findings add evidences for an objective and practical biopsy standard to guide colposcopy in cervical cancer screening programs in low-and middle-income countries. | Yuqian Zhao Fanghui Zhao Shangying Hu Xun Zhang Wenhua Zhang Qinjing Pan Julia C Gage Rengaswamy Sankaranarayanan Youlin Qiao | 2020 | Chinese Journal of Cancer Research2020，32，3： | 1 |
| 12 | A tectonic escape model for the formation of sedimentary basins in the Yangzhou block o~ the Lower Yangtze Region, eastern China显示文摘 | ShangY J YueZQ XiaBD etal | 2002 | Jour- nal of Asian Earth Sciences2002，20，： | 1 |
| 13 | The Mg-chelatase H subunit of Arabidopsis antagonizes a group of WRKY transcription repressors to relieve ABA-responsive genes of inhibition显示文摘 | ShangY Yan L Liu ZQ | 2010 | Plant Cell2010，22，： | 1 |
| 14 | Effect of nonionic co-surfaetants on corrosion inhibition effect of cationic Gemini surfaetant 显示文摘 | PI Y Y SHANGY Z PENG C J | 2010 | J Colloid Surf2010，355，123： | 1 |
| 15 | Preparation ofpositively charged oil/water nano-emulsions with a sub-PITmethod显示文摘 | Mei Zhen Liu Shangying Wang Lei | 2011 | J Colloid Interface Sci2011，361，2： | 1 |
| 16 | Phase behavior of butanol/octane/water/cationic gemini surfactant system 显示文摘 | CHEN L E SHANGY Z Liu H L | 2006 | Journal of Dispersion Scicence and Technologh2006，27，： | 1 |
| 17 | Pickering emulsions stabilized solely by layered double hydroxides particles: The effect of salt on emulsion formation and stability 显示文摘 | Yang Fei Liu Shangying Xu Jian | 2006 | Journal of Colloid and Interface Science2006，302，： | 1 |
| 18 | Pickering emulsions stabilized solely by layered double hydroxides particles: The effect of salt on emulsion formation and stability显示文摘 | Fei Yang Shangying Liu Jian Xu Qiang Lan Fang Wei Dejun Sun | 2006 | Journal of Colloid And Interface Science2006，，1： | 1 |
| 19 | Effect of poly (oxypropylene) diamine adsorption on hydration and dispersion of montmorillonite particles in aqueous solution显示文摘 | WANG Lei LIU Shangying WANG Tian | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，381，1： | 1 |
| 20 | 基于上皮–间质转化标志物的循环肿瘤细胞表型检测对HER2阴性转移性乳腺癌一线化疗的预后意义显示文摘背景与目的上皮–间质转化(epithelia-mesenchymal,EMT)参与肿瘤细胞的转移,并且对基于上皮细胞黏附分子的循环肿瘤细胞(circulating tumor cells,CTCs)检测技术提出了挑战,CTCs已被证实是转移性乳腺癌的预后指标。虽然有证据表明基于EMT标志物的CTCs异质性与疾病进展相关,但在临床应用方面尚无统一的参考标准。本研究旨在评估基于EMT的动态CTCs检测对转移性乳腺癌患者的预后意义。方法我们从CAMELLIA III期前瞻性研究中招募了108例人表皮生长因子受体2阴性转移性乳腺癌患者,并应用CanPatrol CTC富集技术检测外周血中不同亚型的CTCs(包括上皮型CTCs、混合型上皮/间质CTCs和间质型CTCs)。应用1年无进展生存(progression-free survival,PFS)率作为界值分别寻找CTC总数和间质CTCs比例的受试者工作曲线来确定最佳阈值,并采用Kaplan-Meier分析和Cox比例风险回归分析验证综合考虑CTC总数和间质型CTCs比例制定的诊断标准的预后价值。结果CTC总数的最佳阈值为9.5[曲线下面积(area under the curve,AUC)=0.538,95%置信区间(confidence interval,CI=0.418–0.657)]及间质CTCs比例为10.7%(AUC=0.581,95%CI:0.463–0.699)作为预测1年PFS率的界值。我们采用CTC总数≥10/5 mL且间质CTCs比例>10.7%的联合标准预测PFS。符合联合标准的患者的中位PFS显著短于不符合标准的患者(6.2个月vs.9.9个月,P=0.010)。根据该标准和显著的临床病理学特征绘制列线图,C指数为0.613(P=0.010)。结论CTC总数和间质CTCs比例的联合标准可用于监测转移性乳腺癌患者的治疗耐药性和预测患者预后。 | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | 癌症2019，38，9： | 1 |
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