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| 1 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 2 | IL-17C 在全身的真菌的感染期间为致命的发炎被要求显示文摘在 interleukin-17 (IL-17 ) 以内 cytokines 的家庭, IL-17A 被知道在对真菌的 infections; 的主人防卫批评;然而,在抗真菌的免疫的另外的 IL-17 家庭成员的功能仍然保持大部分未知。这里,我们证明那 IL-17C 表情高度在肾被导致在真菌的感染以后的上皮的房间。缺乏 IL-17C 的老鼠展出了增加的幸存并且稀释了肾织物损坏,尽管他们喝了类似的真菌的精液。IL-17C 缺乏与野类型的控制鼠标相比导致了减少的支持 inflammatory cytokine 表示。另外, IL-17C 直接在 vitro 对肾的上皮的房间起作用支持支持 inflammatory cytokine 生产。一起拿,我们的数据证明 IL-17C 是加强的一个关键因素煽动性的回答和原因在真菌的感染期间招待损害。 | Jinling Huang Shaoshuai Meng Shanjuan Hong Xin Lin Wei Jin Chen Dong | 2016 | Cellular & Molecular Immunology2016，13，4： | 7 |
| 3 | Telomerase Activity in Condyloma Acuminatum Tissue with Different HPV Types显示文摘Summary: The telomerse activity in condyloma acuminatum (CA) tissue with human papillomavirus (HPV) types of 6/11 and 16/18 was detected to investigate the function of telomerase in the occurrence, development and carcinogenesis of genital CA. Forty-two biopsies from patients with gennital CA and 30 control tissue samples were tested for telomerase activity, HPV presence and types. The telomerase activity was determined by modified telomerase repeat amplification protocol (TRAP) assay and HPV typing by polymerase chain reaction (PCR) with typing-specific primers. Results showed that HPV-DNA was negative and the expression rate of telomerase was 16.7 % in all normal skin samples. All CA samples were positive for HPV (6/11 type was found in 32 cases, 16/18 in 3 and mixed type in 7). Telomerase activity was detectable in all CA patients. The telomerase activity in CA of 16/18 type was apparently higher than in CA of 6/11 type. It was concluded that the hyperplasia in CA might be increased as a result of HPV infection, suggesting that the activation of telomerase by HPV, especially by 16/18 type may play a role in the etiology and carcinogenesis of genital CA. | TU Yating (涂亚庭) CHEN Shanjuan(陈善娟) FAN Chao(樊超) LIN Nengxing(林能兴) LIU Houjun(刘厚君) LIU Zhixiabg(刘志香) | 2002 | Journal of Huazhong University of Science and Technology(Medical Sciences)2002，22，2： | 3 |
| 4 | Analysis of VISTA expression and function in renal cell carcinoma highlights VISTA as a potential target for immunotherapy显示文摘Dear Editor,Tumors evade immune surveillances,in part via negative regulatory pathways(also called checkpoints)that also regulate immune toleranee to autoimmunity(Thommen et al.,2018).Checkpoint inhibitor therapy,i.e.,anti-CTLA-4 and anti-PD-1,has been approved to be an effective therapeutic approach in a variety of cancers(Mariathasan et al.,2018).However,only a subset of cancer patients shows durable responses(Callahan et al.,2016),urging for a broader investigation beyond PD-1 and CTLA-4. | Shanjuan Hong Qing Yuan Haizhui Xia Genzhen Zhu Yu Feng Qiang Wang Zhiyin Zhang Wei He Jian Lu Chen Dong Ling Ni | 2019 | Protein & Cell2019，10，11： | 2 |
| 5 | Study of aided diagnosis of hepatic carcinoma based on artificial neural network combined with tumor marker group显示文摘 | Shanjuan Tan Feifei Feng Yongjun Wu | 2012 | Physics Procedia2012，33，6： | 1 |
| 6 | Fingerprint matching based on extreme learning machine显示文摘 | Jucheng Yang Shanjuan Xie Sook Yoon Dongsun Park Zhijun Fang Shouyuan Yang | 2013 | Neural Computing and Applications2013，，3： | 1 |
| 7 | SAHA, an HDAC inhibitor, synergizes with tacrolimus to Prevent murine cardiac allograft rejection显示文摘Suberoylanilide hydroxamic 酸(SAHA ) 一个 histone deacetylase (HDAC ) 禁止者(HDACi ) ,最近被发现展出抑制免疫力的效果。然而,是否有拒绝和它的内在的机制尚待禁止 allograft 的 calcineurin 禁止者(CNI ) 的 SAHA 罐头 synergize 逃犯。在这研究,我们在延长 allograft 幸存在表明了 SAHA 的 synergistic 效果和 tacrolimus (FK506 ) 的非治疗学的剂量一鼠科心脏移植模型。伴随物 intragraft 检查表明从对待 SAHA 的接受者的 allografts 显著地证明 IL-17 表示的底层,和为 IL-17 表情的没有可辨别的差别被检测在之间对待 SAHA 并且 SAHA/FK506-treated allograft 作为与从对待 FK506 的动物的 allografts 相比。相反, FK506 的管理显著地压制了干扰素(IFN )-γ但是作为与对待 SAHA 的动物,和这效果的相比增加了 IL-10 表示独立于 SAHA。有趣地,有 FK506 到的 SAHA synergizes 支持 Foxp3 和 CTLA4 表示。在 vitro, SAHA 在孤立的 CD4 +T 房间减少了 Th17 房间的比例人口和 IL-17A, IL-17F, STAT3 和 RORγ 的减少的表情;在这些房间的 t。而且, SAHA 由 upregulating 提高规章的 T (Treg ) 房间的镇压功能没有影响 T 受动器房间增长的 CTLA-4 的表达式,并且由有选择地支持 T 受动器房间的 apoptosis 增加了 Treg 的比例。因此, SAHA, HDACi,可以是有与 CNI 药一起的潜在的利益的一个有希望的抑制免疫力的代理人。 | Xin Zhang Shu Hann Yindong Kang Meng Guo Shanjuan Hong Fang Liu Shangxi Fu Liming Wang Quan-Xing Wang | 2012 | Cellular & Molecular Immunology2012，9，5： | 1 |
| 8 | Analysis of the effects of donor and recipient hepatitis C infection on kidney transplant outcomes in the United States显示文摘BACKGROUND As Hepatitis C virus infection(HCV+)rates in kidney donors and transplant recipients rise,direct-acting antivirals(DAA)may affect outcomes.AIM To analyze the effects of HCV+in donors,recipients,or both,on deceased-donor(DD)kidney transplantation(KT)outcomes,and the impact of DAAs on those effects.METHODS The Organ Procurement and Transplantation Network data of adult first solitary DD-KT recipients 1994-2019 were allocated into four groups by donor and recipient HCV+status.We performed patient survival(PS)and death-censored graft survival(DCGS)pairwise comparisons after propensity score matching to assess the effects of HCV+in donors and/or recipients,stratifying our study by DAA era to evaluate potential effect modification.RESULTS Pre-DAA,for HCV+recipients,receiving an HCV+kidney was associated with 1.28-fold higher mortality(HR 1.151.281.42)and 1.22-fold higher death-censored graft failure(HR 1.081.221.39)compared to receiving an HCV-kidney and the absolute risk difference was 3.3%(95%CI:1.8%-4.7%)for PS and 3.1%(95%CI:1.2%-5%)for DCGS at 3 years.The HCV dual-infection(donor plus recipient)group had worse PS(0.56-fold)and DCGS(0.71-fold)than the dual-uninfected.Donor HCV+derived worse post-transplant outcomes than recipient HCV+(PS 0.36-fold,DCGS 0.34-fold).In the DAA era,the risk associated with HCV+in donors and/or recipients was no longer statistically significant,except for impaired PS in the dual-infected vs dual-uninfected(0.43-fold).CONCLUSION Prior to DAA introduction,donor HCV+negatively influenced kidney transplant outcomes in all recipients,while recipient infection only relatively impaired outcomes for uninfected donors.These adverse effects disappeared with the introduction of DAA. | Qing Yuan Shanjuan Hong Gregory Leya Eve Roth Georgios Tsoulfas WW Williams Joren C Madsen Nahel Elias | 2023 | World Journal of Transplantation2023，13，2： | 0 |
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