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    题名 作者 年代 出处 被引量
1抛开设计拙劣的PBL方法,探索临床前医学教育中案例学习的新模式显示文摘尽管PBL教学模式在全球医学教育领域受到了广泛推崇,还是有反对的声音存在。本文作者系统分析了PBL方法的各个教学环节,对其理念和做法提出了质疑。在阐明自己观点的同时,作者也提出了关于案例学习的新设想,介绍了一种已经成功运用的案例教学新方法。全面了解正反两方面的观点并进行客观分析,对理性思考和审慎实施医学教育改革大有益处。Paul Shanley 汪青 2008复旦教育论坛2008,6,1:42
2Hotspots of the sensitivity of the land surface hydrological cycle to climate change显示文摘Due to the shortage of the global observational data of the terrestrial hydrological variables,the understanding of how surface hydrological processes respond to climate change is still limited.In this study,the Community Land Model(CLM4.0)with high resolution atmospheric forcing data is selected to simulate the global surface hydrological quantities during the period 1948–2006and to investigate the spatial features of these quantities in response to climate change at the regional scales.The sensitivities of evaporation and runoff with respect to the dominant climate change factors(e.g.temperature and precipitation)derived from the concept of climate elasticity are introduced.Results show that evaporation has a declining trend with a rate of 0.7 mm per decade,while runoff shows a weak increasing trend of 0.15 mm per decade over the global land surface.Analyses of the hotspots in the hydrological cycle indicate that the spatial distributions for evaporation and runoff are similar over many areas in central Asia,Australia,and southern South America,but differ largely in high latitudes.It is also found that,the evaporation hotspots in arid regions are mainly associated with the changes in precipitation.Our sensitive analysis suggests that the hydrological quantities show a rather complicated spatial dependency of response of the water cycle to the different climate factors(temperature and precipitation).HUA WenJian CHEN HaiShan ZHU SiGuang SUN ShanLei YU Miao ZHOU LiMing 2013Chinese Science Bulletin2013,58,30:7
3Regional Features and Seasonality of Land–Atmosphere Coupling over Eastern China显示文摘Land-atmosphere coupling is a key process of the climate system, and various coupling mechanisms have been proposed before based on observational and numerical analyses. The impact of soil moisture(SM) on evapotranspiration(ET) and further surface temperature(ST) is an important aspect of such coupling. Using ERA-Interim data and CLM4.0 offline simulation results, this study further explores the relationships between SM/ST and ET to better understand the complex nature of the land-atmosphere coupling(i.e., spatial and seasonal variations) in eastern China, a typical monsoon area. It is found that two diagnostics of land-atmosphere coupling(i.e., SM-ET correlation and ST-ET correlation) are highly dependent on the climatology of SM and ST. By combining the SM-ET and ST-ET relationships, two 'hot spots' of land-atmosphere coupling over eastern China are identified: Southwest China and North China. In Southwest China, ST is relatively high throughout the year, but SM is lowest in spring, resulting in a strong coupling in spring. However, in North China, SM is relatively low throughout the year, but ST is highest in summer, which leads to the strongest coupling in summer. Our results emphasize the dependence of land-atmosphere coupling on the seasonal evolution of climatic conditions and have implications for future studies related to land surface feedbacks.Chujie GAO Haishan CHEN Shanlei SUN Bei XU Victor ONGOMA Siguang ZHU Hedi MA Xing LI 2018Advances in Atmospheric Sciences2018,35,6:5
4Evaluating the Capabilities of Soil Enthalpy, Soil Moisture and Soil Temperature in Predicting Seasonal Precipitation显示文摘Soil enthalpy(H) contains the combined effects of both soil moisture(w) and soil temperature(T) in the land surface hydrothermal process. In this study, the sensitivities of H to w and T are investigated using the multi-linear regression method.Results indicate that T generally makes positive contributions to H, while w exhibits different(positive or negative) impacts due to soil ice effects. For example, w negatively contributes to H if soil contains more ice; however, after soil ice melts,w exerts positive contributions. In particular, due to lower w interannual variabilities in the deep soil layer(i.e., the fifth layer), H is more sensitive to T than to w. Moreover, to compare the potential capabilities of H, w and T in precipitation(P) prediction, the Huanghe–Huaihe Basin(HHB) and Southeast China(SEC), with similar sensitivities of H to w and T,are selected. Analyses show that, despite similar spatial distributions of H–P and T –P correlation coefficients, the former values are always higher than the latter ones. Furthermore, H provides the most effective signals for P prediction over HHB and SEC, i.e., a significant leading correlation between May H and early summer(June) P. In summary, H, which integrates the effects of T and w as an independent variable, has greater capabilities in monitoring land surface heating and improving seasonal P prediction relative to individual land surface factors(e.g., T and w).Changyu ZHAO Haishan CHEN Shanlei SUN 2018Advances in Atmospheric Sciences2018,35,4:3
5Effects of soy isoflavone extracts on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized nude mice显示文摘In this study,we explored the effects of soy isoflavone extracts on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. The ovariectomized athymic mice were implanted with MCF-7 cells. They were fed with low,moderate and high doses of soy isoflavone extracts,at dietary concentrations of 6.25,12.5 and 25 g/kg,respectively. The expression of ki-67 was detected by immunohistochemistry. The pS2 expression in tumors was analyzed by real-time PCR. Estrogen level in the serum was measured by chemiluminescence enzyme immunoassay. Com-pared with the control group,dietary soy isoflavone extracts had a significant stimulatory effect on MCF-7 tumor growth in mice (P < 0.05). The ki-67 and pS2 mRNA expressions in tumors were signifi-cantly increased by 6.25 and 12.5 g/kg dose of soy isoflavone extracts (P < 0.05). And,estrogen level in serum of 6.25 and 12.5 g/kg dose groups was higher than that of control group (P > 0.05). In conclusion,in the tested dietary concentration range soy isoflavone extracts had a stimulatory effect on tumor growth. 6.25 and 12.5 g/kg doses of soy isoflavone extracts can increase the cell proliferation in tumors and induce estrogen-responsive pS2 expression.WU Qian JIN NianZu YU Jing ZHAO RenChen YU ZePing QIAO ShanLei LU XiaoHe ZHANG ChunWen 2009Chinese Science Bulletin2009,54,1:2
6IL-17–Induced Pulmonary Pathogenesis during Respiratory Viral Infection and Exacerbation of Allergic Disease显示文摘Sumanta Mukherjee Dennis M. Lindell Aaron A. Berlin Susan B. Morris Thomas P. Shanley Marc B. Hershenson Nicholas W. Lukacs 2011The American Journal of Pathology2011,,1:2
7Predicting facies architecture through sequence stratigraphy-an example from the Kaiparowits Plateau, Utah 显示文摘Shanley K W McCabe P J 1991Geology1991,19,3:1
8In vivo suppression of NF-kb and preservation of Ikb by Interleukin-13显示文摘Lentsch AB Shanley TP Sarma V 1997Clin Invest1997,100,10:1
9Topography of focal proximal tubular necrosis after ischemia with reflow in the rat kidney显示文摘Shanley PF Rosen MD Brezis M 1986Am J Pathol1986,122,3:1
10The role of sphingosine - 1 - phosphate and ceramide - 1 - phosphate in calcium homeostasis 显示文摘Hinkovska - Galcheva V VanWay SM Shanley TP 2008Current Opinion Invest Drugs2008,9,:1
11Caring for the older person in the emergency department:the ASET program and the role of the ASET clinical nurse consultant in South Western Sydney显示文摘Shanley C Sutherland S Tumeth R 0,,02:1
12Factors affecting the severity of spontaneous retroperitoneal hemorrhage in anticoagulated patients显示文摘Shah RD Nagar S Shanley C J 2008Am J Surg2008,195,3:1
13Factors controlling prolific gas production from low-permeability sandstone reservoirs: Implications for resource assessment, prospect development, and risk analysis显示文摘Shanley KW Cluff RM Robinson JW 2004AAPG Bulletin2004,88,8:1
14Factors cantrolling prolific gas production from low-permeability sandstone reservoirs:Implications for resource assessment,prospect development,and risk analysis显示文摘Shanley K W Cluff R M Robinson J W 2004AAPG Bulletin2004,88,8:1
15Perspectives on the sequence stratigraphy of continental strata 显示文摘Shanley K W McCabe P J 1994AAPG1994,78,4:1
16New venture survival: ignorance, external shocks, and risk re- duction strategies 显示文摘SHEPHERD D A DOUFLAS E J SHANLEY M 2000Journal of Business Venture2000,15,56:1
17Regulation andlocalization of tyrosine216 phosphorylation of glycogen synthasekinase-3 p in cellular and animal models of neuronal degeneration显示文摘Bhat R V Shanley J Correll M P 2000Proc Natl Acad Sci USA2000,97,11:1
18Visceral artery aneurysms显示文摘Messina LM Shanley CJ 1997Surg Clin North Am1997,77,:1
19Delineation and Analy- sis of Clusters in Orientation Data显示文摘SHANLEY R J MAHTAB M A 1976Mathematical Ge- ology1976,8,3:1
20Factors controlling pro- lific gas production from low - permeability sandstone reser- voirs:implications for resource assessment, prospect develop- ment and risk analysis显示文摘Shanley K Cluff R M Robinson J W 2004AAPGBulletin2004,,8:1
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