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| 1 | Anlotinib has good efficacy and low toxicity: a phase Ⅱ study of anlotinib in pre-treated HER-2 negative metastatic breast cancer显示文摘Objective:Anlotinib is a novel tyrosine kinase inhibitor blocking angiogenesis.This study was performed to assess the efficacy and safety of anlotinib in patients with metastatic breast cancer.Methods:Patients with HER2-negative breast cancer,who were pre-treated with anthracycline or taxanes in a neoadjuvant,adjuvant,or metastatic setting,and had treatment failure after at least one prior chemotherapy regimen in the metastatic setting were enrolled.Anlotinib was administered at 12 mg daily for 14 days in a 21-day cycle until disease progression or unacceptable toxicity occurred.Simultaneously,5–10 m L of venous blood was collected to perform circulating tumor DNA(ct DNA)testing every 2 treatment cycles.The primary endpoint was the objective response rate(ORR).Secondary endpoints included the disease control rate(DCR),progression-free survival(PFS),overall survival,safety,and biomarkers.Results:Twenty-six eligible patients were enrolled,with a median age of 56(30–75)years.The median follow-up time was 10.5 months.The ORR was 15.4%,the DCR was 80.8%,and the median PFS was 5.22 months(95%confidence interval 2.86–6.24).Fourteen(53.8%)patients survived for more than 10 months.The changes in the detectable ct DNA variant allele frequency were consistent with the tumor response.The most common treatment-related adverse events were hypertension(57.7%),thyroidstimulating hormone elevation(34.6%),and hand-foot syndrome(23.1%).Conclusion:Anlotinib showed objective efficacy with tolerable toxicity in heavily pre-treated,metastatic HER2-negative breast cancer.The dynamic changes in the ct DNA variant allele fraction may be predictive of the tumor response. | Nanlin Hu Yiran Si Jian Yue Tingting Sun Xue Wang Zhuqing Jia Songlin Gao Qiao Li Yang Shao Jiayu Wang Yang Luo Fei Ma Binghe Xu Peng Yuan | 2021 | Cancer Biology & Medicine2021，18，3： | 11 |
| 2 | FINITENESS CONDITIONS FOR GENERALIZED EXPONENTS OF DIGRAPHS显示文摘Necessary and sufficient conditions are given for the finiteness of the generalized exponents expD(k), f(D, k) and F(D, k) for digraphs which are not necessarily primitive. Also the largest finite value of the generalized exponent expD(k) for digraphs of order n is determined and the complete characterizations of the extreme digraphs are given. | SHAO JIAYU (Department of Applied Mathematics, Tonsil University, Shanghai 200092, China.)WU XIAOJUN (Project supported by the National Natural Science FOundation of China and Shanghai Science anda’echnolgy Developing FOundation.) | 1998 | Chinese Annals of Mathematics,Series B1998，19，4： | 5 |
| 3 | TOPSIS Based Assessment of Sustainable Water Resources Utilization显示文摘Based on water resources conditions,social development,social economy and ecological conditions,the Indicators system for sustainability assessment of water resources use( ISSAWRU) was established for Yinchuan City. Using the Technique for Order of Preference by Similarity to Ideal Solution( TOPSIS),the sustainable development and utilization plan of water resources was assessed for Yinchuan City during 2010-2014. In 2010-2014,there were no significant changes in the natural conditions of water resources in Yinchuan City; however,with the promulgation of national water resources related policies,Yinchuan City realized gradual increase in the water resources utilization rate,gradual improvement in the ecological environment,and gradual optimization of water resources sustainable utilization situation at the same time of ensuring rapid economic growth. | Lian TANG Yongliang WANG Zixi LIU Jiayue SHAO | 2018 | Asian Agricultural Research2018，10，10： | 4 |
| 4 | Deleting Vertices and Interlacing Laplacian Eigenvalues显示文摘The authors obtain an interlacing relation between the Laplacian spectra of a graph G and its subgraph G-U,which is obtained from G by deleting all the vertices in the vertex subset U together with their incident edges.Also,some applications of this interlacing property are explored and this interlacing property is extended to the edge weighted graphs. | Baofeng WU Jiayu SHAO Xiying YUAN | 2010 | Chinese Annals of Mathematics,Series B2010，31，2： | 3 |
| 5 | Bounds on the bases of irreducible generalized sign pattern matrices显示文摘 | Shao Jiayu You Lihua | 2007 | Linear Algebra Appl2007，427，23： | 1 |
| 6 | Bounds on the bases of irreducible generalize sign pattern matrix显示文摘 | You Lihua Shao Jiayu Shan Haiying | 2007 | Linear Algebra Appl2007，427，： | 1 |
| 7 | On the index d maximum density for irreducible Boolean matrices显示文摘 | SHAO Jiayu LI Qiao | 1988 | Diatribe Applied Mathematics1988，21，： | 1 |
| 8 | The determinantal regions of complex sign pattern matrices and ray pattern matrices显示文摘 | Shao Jiayu Shan Haiying | 2005 | Linear Algebra Appl2005，395，： | 1 |
| 9 | The inverse problems of the determinantal regions of ray pattern and complex sign pattern matrices显示文摘 | Shao Jiayu Liu Yue Ren Lingzhi | 2006 | Linear Algebra Appl2006，416，： | 1 |
| 10 | Bounds on the bases of irreducible generalized sign pattern matrices显示文摘 | You Lihua Shao Jiayu Shan Haiying | 2007 | Linear Algebra and its Applications2007，427，： | 1 |
| 11 | On the boundaries of the determinantal regions of ray pattern matrices显示文摘 | Liu Yue Shao Jiayu He Changxiang | 2008 | Linear Algebra Appl2008，428，： | 1 |
| 12 | On the exponent of a primitive digraph显示文摘 | SHAO Jiayu | 1985 | Linear Algebra and Its Applications1985，64，： | 1 |
| 13 | Bounds on the bases of irreducible generalized sign pattern matrices显示文摘 | You Lihua Shao Jiayu | 2007 | Linear Algebra and its Applications2007，427，： | 1 |
| 14 | Bounds on the basis of irreducible generalized sign pattern matrices显示文摘 | Shao Jiayu You Lihua | | 0，，2： | 1 |
| 15 | Bounds on the bases of irreducible generalized sign pattern matrices 显示文摘 | You Lihua Shao Jiayu Shan Haiying | 2007 | Linear Algebra and its Applications2007，427，： | 1 |
| 16 | Bounds on the bases of irreducible generalized sign pattern matrices 显示文摘 | You Lihua Shao Jiayu Shan Haiying | 2007 | Linear Algebra and its Applications2007，427，： | 1 |
| 17 | Ray solvable linear systems and ray S2NS matrices显示文摘 | SHAO Jiayu SHAN Haiying | 2005 | Linear Algebra and Its Applications2005，，395： | 1 |
| 18 | On the digraphs of sign solvable linear systems显示文摘 | SHAO Jiayu | 2000 | Linear Algebra and its Applications2000，，313： | 1 |
| 19 | Bounds on the bases of irreducible generalize sign pattern matrix显示文摘 | You Lihua Shao Jiayu Shan Haiying | 2007 | Linear Algebra Appl2007，427，： | 1 |
| 20 | Formation of hydrophobic coating on PMMA surface using unipolar nanosecond-pulse DBD in atmospheric air显示文摘 | Xu Jiayu Zhang Cheng Shao Tao | | 0，，03： | 1 |
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