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您的检索式：作者名="Shaocong Mo"
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| 1 | Single-cell dissection,hdWGCNA and deep learning reveal the role of oxidatively stressed plasma cells in ulcerative colitis显示文摘Ulcerative colitis(UC)develops as a result of complex interactions between various cell types in the mucosal microenvironment.In this study,we aim to elucidate the pathogenesis of ulcerative colitis at the single-cell level and unveil its clinical significance.Using single-cell RNA sequencing and high-dimensional weighted gene co-expres-sion network analysis,we identify a subpopulation of plasma cells(PCs)with significantly increased infiltration in UC colonic mucosa,characterized by pronounced oxidative stress.Combining 10 machine learning approaches,we find that the PC oxidative stress genes accurately distinguish diseased mucosa from normal mucosa(independent external testing AUC=0.991,sensitivity=0.986,specificity=0.909).Using MCPcounter and non-negative matrix factorization,we identify the association between PC oxidative stress genes and immune cell infiltration as well as patient heterogeneity.Spatial transcriptome data is used to verify the infiltration of oxidatively stressed PCs in colitis.Finally,we develop a gene-immune convolutional neural network deep learning model to diagnose UC mucosa in different cohorts(independent external testing AUC=0.984,sensitivity=95.9%,specificity=100%).Our work sheds light on the key pathogenic cell subpopulations in UC and is essential for the development of future clinical disease diagnostic tools. | Shaocong Mo Xin Shen Baoxiang Huang Yulin Wang Lingxi Lin Qiuming Chen Meilin Weng Takehito Sugasawa Wenchao Gu Yoshito Tsushima Takahito Nakajima | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 2 | Intracontinental Orogenic Igneous Rocks and Orogenic Processes in Qinghai-Xizang-Himalaya显示文摘Based on the discussion on the intracontinental orogenic igneous rocks formed after India- Asia collision (40 or 45 Ma ),the intracontinemal orogenic processes of Qinghai-Xizang (Tibet)-Himalaya are traced . Muscovite/two mica granite is considered as a petrological record of intracontinental subduction. Volcanic rocks of shoshonite series are believed to be the products of the orogenic and outside cratonic lithosphere convergence . The intracontinental orogenic igneous rocks are developed only on the margins of the orogenic belt. The pairing phenomenon of the igneous rock zones is regarded as one of the best signs to recognize the special range of orogenic belt . The stage of magmatic activity is a representation and indicator of orogenic episode . Three pairs of the igneous events in Oligocene , Miocene and Pleistocene and their space distribution indicate three corresponding orogenic episodes and the horizontal expansion across the orogenic belt , respectively , On the northern and southern margins | Deng Jinfu Zhao Hailing Lai Shaocong Li Yuwen Liu Houxiang Mo Xuanxue Di YongjunDepartment of Geology and Mineral Resources , China University of Geosciences , Beijing 100083 | 1995 | Journal of Earth Science1995，14，2： | 0 |
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