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| 1 | PLMD:An updated data resource of protein lysine modifications显示文摘Post-translational modifications(PTMs) occurring at protein lysine residues,or protein lysine modifications(PLMs),play critical roles in regulating biological processes.Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types,here we greatly updated our previous studies,and presented a much more integrative resource of protein lysine modification database(PLMD).In PLMD,we totally collected and integrated 284,780 modification events in 53,501 proteins across 176 eukaryotes and prokaryotes for up to 20 types of PLMs,including ubiquitination,acetylation,sumoylation,methylation,succinylation,malonylation,glutarylation,giycation,formylation,hydroxylation,butyrylation,propionylation,crotonylation,pupylation,neddylation,2-hydroxyisobutyrylation,phosphoglycerylation,carboxylation,lipoylation and biotinylation.Using the data set,a motif-based analysis was performed for each PLM type,and the results demonstrated that different PLM types preferentially recognize distinct sequence motifs for the modifications.Moreover,various PLMs synergistically orchestrate specific cellular biological processes by mutual crosstalks with each other,and we totally found 65,297 PLM events involved in 90 types of PLM co-occurrences on the same lysine residues.Finally,various options were provided for accessing the data,while original references and other annotations were also present for each PLM substrate.Taken together,we anticipated the PLMD database can serve as a useful resource for further researches of PLMs.PLMD 3.0 was implemented in PHP + MySQL and freely available at http://gffzz60b5e5c25d7e4f27hwxvk9knqp5fx6bcx.ffgz.tsg.suse.edu.cn. | Haodong Xu Jiaqi Zhou Shaofeng Lin Wankun Deng Ying Zhang Yu Xue | 2017 | Journal of Genetics and Genomics2017，44，5： | 6 |
| 2 | Facile self-template fabrication of hierarchical nickel-cobalt phosphide hollow nanoflowers with enhanced hydrogen generation performance显示文摘Developing facile methods to construct hierarchical-structured transition metal phosphides is beneficial for achieving high-efficiency hydrogen evolution catalysts.Herein,a self-template strategy of hydrothermal treatment of solid Ni-Co glycerate nanospheres followed by phosphorization is delivered to synthesize hierarchical Ni Co P hollow nanoflowers with ultrathin nanosheet assembly.The microstructure of Ni Co P can be availably tailored by adjusting the hydrothermal treatment temperature through affecting the hydrolysis process of Ni-Co glycerate nanospheres and the occurred Kirkendall effect.Benefitting from the promoted exposure of active sites and affluent mass diffusion routes,the HER performance of the Ni Co P hollow nanoflowers has been obviously enhanced in contrast with the solid Ni Co P nanospheres.The fabricated Ni Co P hollow nanoflowers yield the current density of 10 m A cmà2at small overpotentials of 95 and 127 m V in 0.5 mol Là1H2SO4and 1.0 mol Là1KOH solution,respectively.Moreover,the two-electrode alkaline cell assembled with the Ni Co P and Ir/C catalysts exhibits sustainable stability for overall water splitting.The work provides a simple but efficient method to regulate the microstructure of transition metal phosphides,which is helpful for achieving high-performance hydrogen evolution catalysts based on solid-state metal alkoxides. | Xupo Liu Shaofeng Deng Peifang Liu Jianing Liang Mingxing Gong Chenglong Lai Yun Lu Tonghui Zhao Deli Wang | 2019 | Science Bulletin2019，64，22： | 2 |
| 3 | PTMD: A Database of Human Disease-associated Post-translational Modifications显示文摘Various posttranslational modifications(PTMs) participate in nearly all aspects of biological processes by regulating protein functions, and aberrant states of PTMs are frequently implicated in human diseases. Therefore, an integral resource of PTM–disease associations(PDAs)would be a great help for both academic research and clinical use. In this work, we reported PTMD,a well-curated database containing PTMs that are associated with human diseases. We manually collected 1950 known PDAs in 749 proteins for 23 types of PTMs and 275 types of diseases from the literature. Database analyses show that phosphorylation has the largest number of disease associations, whereas neurologic diseases have the largest number of PTM associations. We classified all known PDAs into six classes according to the PTM status in diseases and demonstrated that the upregulation and presence of PTM events account for a predominant proportion of diseaseassociated PTM events. By reconstructing a disease–gene network, we observed that breast cancershave the largest number of associated PTMs and AKT1 has the largest number of PTMs connected to diseases. Finally, the PTMD database was developed with detailed annotations and can be a useful resource for further analyzing the relations between PTMs and human diseases. PTMD is freely accessible at http://gffzz7d3e84778ac14081hwxvk9knqp5fx6bcx.ffgz.tsg.suse.edu.cn. | Haodong Xu Yongbo Wang Shaofeng Lin Wankun Deng Di Peng Qinghua Cui Yu Xue | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 2 |
| 4 | An Efficient Two-Party Key Exchange Protocol with Strong Security显示文摘Combined public key (CPK) cryptography does not need certificates to guarantee the authenticity of public keys and avoids the inherent key escrow problem of identity-based cryptography. Based on the efficient CPK scheme, we present an efficient three-round two-party authenticated key exchange protocol with strong security, which is provably secure in the standard model under the decisional Diffie-Hellman (DDH) assumption. The protocol can keep the session key secret from the adversary except that one party's ephemeral private key and static private key are all revealed to the adversary. Compared to the existing protocols, this protocol not only assures strong security but also is more efficient. | DENG Shaofeng LI Yifa DENG Yiqun | 2010 | Wuhan University Journal of Natural Sciences2010，15，3： | 1 |
| 5 | Potential Antiviral Target for SARS-CoV-2:A Key Early Responsive Kinase during Viral Entry显示文摘Currently,there is no effective antiviral medication for coronavirus disease 2019(COVID-19)and the knowledge on the potential therapeutic target is in great need.Guided by a time-course transmission electron microscope(TEM)imaging,we analyzed early phosphorylation dynamics within the first 15 min during severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)viral entry.Based on alterations in the phosphorylation events,we found that kinase activities such as protein kinase C(PKC),interleukin-1 receptor-associated kinase 4(IRAK4),MAP/microtubule affinity-regulating kinase 3(MARK3),and TANK-binding kinase 1(TBK1)were affected within 15 min of infection.Application of the corresponding kinase inhibitors of PKC,IRAK4,and p38 showed significant inhibition of SARS-CoV-2 replication.Additionally,proinflammatory cytokine production was reduced by applying PKC and p38 inhibitors.By an acquisition of a combined image data using positiveand negative-sense RNA probes,as well as pseudovirus entry assay,we demonstrated that PKC contributed to viral entry into the host cell,and therefore,could be a potential COVID-19 therapeutic target. | Siwen Liu Lin Zhu Guangshan Xie Bobo Wing-Yee Mok Zhu Yang Shaofeng Deng Siu-Ying Lau Pin Chen Pui Wang Honglin Chen Zongwei Cai | 2022 | CCS Chemistry2022，4，1： | 1 |
| 6 | WocEA:The visualization of functional enrichment results in word clouds显示文摘The integration,analysis and visualization of the big omics data are critical for addressing a broad spectrum of biological questions.One of the most frequently conducted procedures is enrichment analysis,which statistically tests whether individual functional annotations of Gene Ontology (GO)or Kyoto Encyclopedia of | Wanshan Ning Shaofeng Lin Jiaqi Zhou Yaping Guo Ying Zhang Di Peng Wankun Deng Yu Xue | 2018 | Journal of Genetics and Genomics2018，45，7： | 1 |
| 7 | Semi-interpenetrating polymer networks toward sulfonated poly(ether ether ketone) membranes for high concentration direct methanol fuel cell显示文摘Low methanol permeability of proton exchange membranes (PEMs) is greatly important for direct methanol fuel cells (DMFCs). Here, sulfonated poly (ether ether ketone) (SPEEK) based semiinterpenetrating polymer networks (semi-IPNs) are successfully prepared by interpenetrating SPEEK into the in-situ synthesized crosslinking networks. The polymeric networks are formed by the covalent bonds between bromobenzyl groups of bro mo methylated poly (phenylene oxide) and amine groups of diamine linkers as well as the ionic bonds between amine species and sulfonated groups. Two linkers without and with sulfonated groups are applied to fabricate the semi-IPNs. The core properties of the membranes, like phase separation, water uptake, proton conductivity and methanol permeability, are systematically studied and compared. The DMFCs assembled by using the semi-IPN membranes display better performance than Nafion 117 in high concentration methanol solutions. The present work provides a facile way to prepare PEMs with enhanced DMFC performance. | Xupo Liu Yunfeng Zhang Shaofeng Deng Cuicui Li Jiaming Dong Jiaying Wang Zehui Yang Deli Wang Hansong Cheng | 2019 | Chinese Chemical Letters2019，30，2： | 1 |
| 8 | Insight into the hydrogen oxidation electrocatalytic performance enhancement on Ni via oxophilic regulation of MoO_(2)显示文摘Exploring platinum-group-metal(PGM)free electrocatalysts for hydrogen oxidation reaction(HOR)in alkaline media is essential to the progress of anion exchange membrane fuel cells(AEMFCs).In this work,a Ni/MoO_(2) heterostructure catalyst with comparable HOR activity in alkaline electrolyte with PGM catalyst was prepared by a simple hydrothermal-reduction method.Remarkably,the Ni/MoO_(2) presents a mass kinetic current density of 38.5 mA mgNi^(-1) at the overpotential of 50 mV,which is higher than that of the best PGM free HOR catalyst reported by far.Moreover,the HOR performance of Ni/MoO_(2) under 100 ppm CO shows negligible fading,together with the superior durability,render it significant potential for application in AEMFCs.A particular mechanistic study indicates that the excellent HOR performance is ascribed to the accelerated Volmer step by the incorporation of MoO_(2).The function of MoO_(2) was further confirmed by CO striping experiment on Pt/C-MoO_(2) that MoO_(2) can facilitated OH adsorption thus accelerate the HOR process.On account of the high performance and low cost,the Ni/MoO_(2) electrocatalyst encourages the establishment of high performance PGM free catalyst and shows significant potential for application in AEMFCs. | Shaofeng Deng Xupo Liu Xuyun Guo Tonghui Zhao Yun Lu Jingyu Cheng Ke Chen Tao Shen Ye Zhu Deli Wang | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
| 9 | A MICROFABRICATED METAL GRATING OSCILLATOR FOR ELECTRIC FIELD DETECTION显示文摘This letter proposes a novel design of a Micro Electro Mechanical System (MEMS) device featuring a metal grating vibratory microstructure driven by electrostatic force to sense the spatial electric field. Due to the advantages in slide-film damping and large vibration amplitude,such a device makes atmospheric packaging a low-cost option for practical manufacture. In this letter, we present the operating principles and specifications, the design structure, as well as the finite element simulation. Computational analysis shows that our design obtains good results in device parameters setting, while its simplicity and low-cost features make it an attractive solution for applications. | Deng Kai Xia Shanhong Gong Chao Chen Shaofeng Bai Qiang | 2005 | Journal of Electronics(China)2005，22，5： | 0 |
| 10 | Molybdenum-doped titanium dioxide supported low-Pt electrocatalyst for highly efficient and stable hydrogen evolution reaction显示文摘The Platinum(Pt)-based catalysts exhibit excellent catalytic performance for the hydrogen evolution reaction(HER) while suffering from poor stability due to the weak interaction between the carbon support and Pt.Herein,a molybdenum-doped titanium dioxide(Ti_(0.9)Mo_(0.1)O_(2)) supported low-Pt electrocatalyst with stronger interaction between catalyst and support is applied to tune the electrocatalytic performance of Pt.The Ti_(0.9)Mo_(0.1)O_(2) support can not only tolerate the corrosion environment in the catalytic system,but also generate strong metal-support inte raction(SMSI) between the oxide and catalyst.A facile solvothermal method is used to prepareTi_(0.9)Mo_(0.1)O_(2) as support to anchor Pt nanoparticles.The 5% Pt supported on Ti_(0.9)Mo_(0.1)O_(2) catalyst exhibits 4.4-fold mass activity(MA) at an overpotential of 50 mV and higher stability than 20% Pt/C with only 1/4 Pt loading.The SMSI between the Ti_(0.9)Mo_(0.1)O_(2) and Pt prevents the Pt aggregation to achieve excellent stability,and hydrogen spillover effect in the interface between Pt and support benefits the hydrogen production process.This work presents a novel sight for the fabrication and design of oxide supported catalysts in various catalytic system by reasonably employing support effect. | Ke Chen Shaofeng Deng Yun Lu Mingxing Gong Yezhou Hu Tonghui Zhao Tao Shen Deli Wang | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 11 | Boosting alkaline hydrogen electrooxidation on an unconventional fcc-Ru polycrystal显示文摘Precisely controlling the crystalline phase structure and exposed facets at the atomic level opens up a new avenue for efficient catalyst design.Along this line,we report an unconventional face-centered cubic(fcc)Ru with twinned structure and stacking-fault defects as a competent electrocatalyst towards alkaline hydrogen oxidation reaction(HOR),which is now a major obstacle for the commercialization of anion exchange membrane fuel cells(AEMFC).With conventional hexagonal close packing(hcp)Ru as the counterpart,a novel scope from the phase-engineering is introduced to identify the activity origin and provide fundamental understanding of the sluggish HOR kinetics in alkaline medium.Systematic electrochemical analysis assisted by deconvoluting the hydrogen(H)desorption peaks indicates the superior performance of fcc Ru origins from the structure defects and higher proportion of the most active sites.DFT calculations,together with CO-stripping voltammograns further corroborate the stronger hydroxyl species(OH^(*))affinity lead to the higher activity on these sites.Meanwhile,it also demonstrates the H^(*)adsorption/desorption on polycrystalline Ru among the conventional'hydrogen region'is accompanied by the surface bound OH^(*)in alkaline medium,which is of great significance for subsequent alkaline HOR exploration and catalyst design. | Tonghui Zhao Dongdong Xiao Yi Chen Xi Tang Mingxing Gong Shaofeng Deng Xupo Liu Jianmin Ma Xu Zhao Deli Wang | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 12 | Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome:A comparative cohort study in China显示文摘Background Venovenous extracorporeal membrane oxygenation(VV-ECMO)has been demonstrated to be effective in treating patients with virus-induced acute respiratory distress syndrome(ARDS).However,whether the management of ECMO is different in treating H1N1 influenza and coronavirus disease 2019(COVID-19)-associated ARDS patients remains unknown.Methods This is a retrospective cohort study.We included 12 VV-ECMO-supported COVID-19 patients admitted to The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Eighth People's Hospital,and Wuhan Union Hospital West Campus between January 23 and March 31,2020.We retrospectively included VV-ECMO-supported patients with COVID-19 and H1N1 influenza-associated ARDS.Clinical characteristics,respiratory mechanics including plateau pressure,driving pressure,mechanical power,ventilatory ratio(VR)and lung compliance,and outcomes were compared.Results Data from 25 patients with COVID-19(n=12)and H1N1(n=13)associated ARDS who had received ECMO support were analyzed.COVID-19 patients were older than H1N1 influenza patients(P=0.004).The partial pressure of arterial carbon dioxide(PaCO_(2))and VR before ECMO initiation were significantly higher in COVID-19 patients than in H1N1 influenza patients(P<0.001 and P=0.004,respectively).COVID-19 patients showed increased plateau and driving pressure compared with H1N1 subjects(P=0.013 and P=0.018,respectively).Patients with COVID-19 remained longer on ECMO support than did H1N1 influenza patients(P=0.015).COVID-19 patients who required ECMO support also had fewer intensive care unit and ventilator-free days than H1N1.Conclusions Compared with H1N1 influenza patients,COVID-19 patients were older and presented with increased PaCO_(2) and VR values before ECMO initiation.The differences between ARDS patients with COVID-19 and influenza on VV-ECMO detailed herein could be helpful for obtaining a better understanding of COVID-19 and for better clinical management. | Yonghao Xu Yin Xi Shuijiang Cai Yuheng Yu Sibei Chen Weijie Guan Weibo Liang Hongkai Wu Weiqun He Xilong Deng Yuanda Xu Rong Zhang Manshu Li Jieyi Pan Zhenting Liang Ya Wang Shaofeng Kong Xiaoqing Liu Zheng Lv Yimin Li | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
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