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2篇 您的检索式：作者名="Shaoxiang Xian"

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		题名	作者	年代	出处	被引量
	1	Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3inflammasome activation in LPS-induced vascular injury显示文摘The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide(2 μg/mL) and administrated by 0.1–2 mmol/L aspirin. The wild type mice were stimulated with LPS(100 μg/kg/day), and 1 h later treated with aspirin(12.5, 62.5, or125 mg/kg/day) and dexamethasone(0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of theendothelial tight junction protein zonula occludens-1/2(ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome.	Xing Zhou Yanjiao Wu Lifeng Ye Yunting Wang Kaimin Zhang Lingjun Wang Yi Huang Lei Wang Shaoxiang Xian Yang Zhang Yang Chen	2019	Acta Pharmaceutica Sinica B2019，9，4：	13
	2	Seawater temperature and salinity sensing based on in-fiber Michelson-Fabry-Perrot hybrid interferometer employing frequency domain decomposition method显示文摘We propose an in-fiber Michelson-Fabry-Perrot(M-FP)hybrid interferometer for the simultaneous measurement of seawater temperature and salinity.The sensor head consists of two parallel hetero Fabry-Perot(FP)cavities fabricated on the end face of the twin core fiber(TCF).A fiber fusion taper is used to split and recouple the light in the two cores.In this case,the Vernier effect can be obtained which can greatly enhance the sensitivity and solve the problem of temperature cross-sensitivity.Different from the traditional demodulation method based on envelop detection,we employed frequency domain decomposition method(FDDM)to demodulate the sensing signal.The simulation results indicate that the proposed sensor has high sensitivity to salinity and temperature.Thanks to the merits of high sensitivity,ease of fabrication and small footprint,the proposed seawater temperature and salinity sensor would have potential applications in marine science,food industry and ocean ranching.	WANG Jiahui WEI Xian ZHU Yan SHEN Yue PANG Lipeng DUAN Shaoxiang	2024	Optoelectronics Letters2024，20，2：	0

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