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| 1 | Renal impairment and heart failure with preserved ejection fraction early post-myocardial infarction显示文摘AIM:To study if impaired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).METHODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after myocardial infarction (MI) were grouped into chronic kidney disease (CKD) stages based on estimated glomerular filtration rate (eGFR).Rates of early post-MI HF were compared among eGFR groups.Logistic regression was used to explore independent predictors of HF.RESULTS:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal impairment (eGFR < 60 mL/min every 1.73 m2) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P < 0.0001),despite a small absolute difference in mean EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function among patients with preserved EF:10.1%,13.6% and 23.6% (P < 0.0001),but this relationship was not significant among patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).Moreover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-MI patients with occluded IRAs have impaired renal function.Impaired renal function was associated with an increased rate of early post-MI HF,the association being strongest in patients with preserved EF.These findings have implications for management of peri-infarct HF. | Vinod Jorapur Gervasio A Lamas Zygmunt P Sadowski Harmony R Reynolds Antonio C Carvalho Christopher E Buller James M Rankin Jean Renkin Philippe Gabriel Steg Harvey D White Carlos Vozzi Eduardo Balcells Michael Ragosta C Edwin Martin Vankeepuram S Srinivas William W Wharton III Staci Abramsky Ana C Mon Shari S Kronsberg Judith S Hochman | 2010 | World Journal of Cardiology2010，2，1： | 1 |
| 2 | In vitro testing of a pulsatile delivery system and its in vivo application for immunization against tetanus toxoid显示文摘 | Michael Cardamone Shari A Lofthouse Jane C Lucas | 1997 | J Controlled Release1997，47，： | 1 |
| 3 | A dynamic in- novation model for managing capabilities of continuous inno- vation 显示文摘 | Shari S C Shang Se-Hwa Wu Chen-yen Yao | 2010 | International Journal of Technology Management2010，51，24： | 1 |
| 4 | Enduring effect of chronic corticosterone treatment on spatial learning,synaptic plasticity,and hippocampal neuropathology in young and mid-aged rats显示文摘 | SHARI R B AARON G H JEMMIFER C L | 1995 | J Neurosci1995，15，1： | 1 |
| 5 | JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis显示文摘 | Girish V Putcha Siyuan Le Stephan Frank Cagri G Besirli Kim Clark Boyang Chu Shari Alix Richard J Youle Art LaMarche Anna C Maroney Eugene M Johnson | 2003 | Neuron2003，，6： | 1 |
| 6 | The antiplatelet effects of ticlopidine and clopidogrel显示文摘 | Sharis P J Cannon C P Loscalzo J | 1998 | Ann Intern Med1998，129，5： | 1 |
| 7 | Dual strategy for managing user resistance with business integration systems显示文摘 | Shang S C Shari | 2012 | Behaviour & Information Technol- ogy2012，31，9： | 1 |
| 8 | Tie individual pay to team success 显示文摘 | SHARI C | 1994 | Personnel Journal1994，73，10： | 1 |
| 9 | Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihy- drofuranones显示文摘 | Gilles B Martijn R Shari C | 2012 | Bioorganic and Medicinal Chemistry2012，20，15： | 1 |
| 10 | The antiplatelet effects of ticlopidine and clopidogrel 显示文摘 | Cannon C Loscanzo J | 1998 | Ann Intern Med1998，129，： | 1 |
| 11 | AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species,most likely by interfering with LuxPQ显示文摘 | Gilles B Shari C Kartik B | 2009 | Microbiolo gy2009，155，： | 1 |
| 12 | UV-C light inactivation kinetics of Penicillium expansum on pearsurfaces: Influence on physicochemical and sensory quality during storage显示文摘 | Roopesh M Shari L Kanishka B Shyam S Dugan F Rasco B Killinger K Dhingra A Ross C | 2014 | Postharvest Biology and Technology2014，87，1： | 1 |
| 13 | A T follicular helper cell origin for T regulatory type 1 cells显示文摘Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express FOxP3.The identities of the progenitor(s)and transcriptional regulators of this T-cell subset remain unclear.Here,we show that the peptide-major histocompatibility complex class Il(pMHCll)monospecific immunoregulatory T-cell pools that arise in vivo in different genetic backgrounds in response to pMHCll-coated nanoparticles(pMHCll-NPs)are invariably comprised of oligoclonal subpools of T follicular helper(TFH)and TR1 cells with a nearly identical clonotypic composition but different functional properties and transcription factor expression profles.Pseudotime analyses of scRNAseq data and multidimensional mass cytometry revealed progressive downregulation and upregulation of TFH and TR1 markers,respectively.Furthermore,pMHCIl-NPs trigger cognate TR1 cell formation in TFH cell-transfused immunodeficient hosts,and T-cell-specific deletion of Bcl6 or Irf4 blunts both the TFH expansion and TR1 formation induced by pMHCl-NPs.In contrast,deletion of Prdm1 selectively abrogates the TFH-to-TR1 conversion.Bcl6 and Prdm1 are also necessary for anti-CD3 mAbinduced TR1 formation.Thus,TFH cells can differentiate into TR1 cells in vivo,and BLIMP1 is a gatekeeper of this cellular reprogramming event. | Patricia Solé Jun Yamanouchi Josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos Julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
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