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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Research progress of monitoring, forecasting, and prevention of rockburst in underground coal mining in China显示文摘As one of the dynamic disasters of coal mines,rockburst seriously affects underground safe coal mining.Based on the laboratory test,field test,and theoretical analysis,this study proposed the principle of the rock burst induced by the combination of dynamic and static stresses and divided such rock burst into three types,including induced by primary dynamic stress,mainly induced by dynamic stress,and by dynamic stress in low critical stress state.The expressions of the static stress induced by coal mining and dynamic stress induced by mining tremors were obtained.Moreover,theories and technologies at home and abroad were summarized concerning the monitoring,forecasting,and preventing of rockburst.These mainly include the zoning and leveling forecasting method,electromagnetic radiation technology,elastic wave and seismic wave computed tomography technologies in aspect of rockburst monitoring,as well as the intensity weakening theory,the strong-soft-strong structure effect,the directional hydraulic fracturing technology,the roadway support system in regards of rockburst prevention.The prospect of rockburst development suggested that researches concerning the rockburst mechanism should be quantitatively developed around the roadway and coalface surrounding coal-rock mass.It should be focused on the rockburst mechanism and prevention technology of mining with over 1,000 km deep and mining in large tectonic zone.In addition,the monitoring and prevention of rockburst should be based on rockburst mechanism. | Linming Dou Zonglong Mu Zhenlei Li Anye Cao Siyuan Gong | 2014 | International Journal of Coal Science & Technology2014，1，3： | 64 |
| 3 | Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells显示文摘Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. | Hui Liu Zeya Pan Aijun Li Siyuan Fu Yin Lei Hangyong Sun Mengchao Wu Weiping Zhou | 2008 | Cellular & Molecular Immunology2008，5，5： | 30 |
| 4 | 土壤、农作物中及家畜体内的微量营养元素(英文)显示文摘微量营养元素通常富集在表层土壤中,其含量随土层深度递减。尽管土壤中大多数微量元素的含量很高,但只有一小部分能被植物吸收。微量营养元素,也被称为痕迹元素,所需数量微小,但其缺乏会对农作物生产和动物健康造成严重影响。农作物对不同微量营养元素有着不同的反应。芸苔和豆类对Mo和B有较高的响应度,而玉米和其他谷类对Zn和Cu较为敏感。在温润和湿热地区,由于强降雨和强淋溶作用,微量营养元素缺乏较为普遍。土壤pH值是影响微量营养元素对植物有效性的重要因素之一。除Mo以外,微量营养元素的有效性随pH的增加而减小,Mo的有效性随pH的增加而增加。对于大多数植物来说,叶片中的微量营养元素含量高于植物的其他部分。因此,可以用叶片作为样品来测定农作物中微量营养元素的含量。大多数微量营养元素缺乏表现在植物顶部的新叶上,而过量则表现在老叶上。根据Deckers和Steinnes的结论,土壤较为贫瘠的发展中国家与土壤肥沃的欧洲及北美地区相比,微量营养元素缺乏现象较为普遍。许多营养元素缺乏区位于潮湿的热带地区,土壤极度贫瘠、高度风化和/或强淋溶,营养元素十分匮乏。此类其他土壤分部于半干旱及毗邻地区,这些地区的碱性和石灰性土壤条件严重限制了微量营养素对植物的供给。通常,可以满足草料作物生长的Cu、Fe、Mn、Zn、Se含量水平,却不能满足家畜的需要。Se是植物生长所不需要的微量元素,因此草料作物中Se的含量很少。然而,如果动物所食农作物和草料中Se含量偏低,会造成严重的肌肉异常和其他疾病。白肌病是最常见的由于Se缺乏造成的疾病,在牛犊和羔羊中都有发现。本文讨论了与动物需求相关的农作物微量营养元素充足度。 | Umesh C. Gupta Wu Kening Liang Siyuan | 2008 | 地学前缘2008，15，5： | 16 |
| 5 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 6 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 7 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 8 | Effects of Saikosaponin-D on syndecan-2,matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma显示文摘OBJECTIVE:To investigate effects of Saikosaponin D(SSd) on syndecan-2,matrix metalloproteinases(MMPs) and tissue inhibitor of metalloproteinases-2(TIMP-2) in livers of rat with hepatocellular carcinoma(HCC).METHODS:Male SD rats were divided into control(n=10),model(n=20) and SSd(n=20) groups,and model and SSd groups given intragastric 0.2%(w/v) N-diethylnitrosamine to induce HCC.SSd group received 0.03%(w/v) SSd in saline.Liver samples were analysed immunohistochemically for syndecan-2,MMP-2,MMP-13 and TIMP-2 at 16 weeks.RESULTS:The model group had more malignant nodules than the SSd group;all model-group HCC cells were grade III;SSd-group HCC cells were grades I-II.Controls showed normal hepatic cell phenotypes and no syndecan-2 + staining.Syndecan-2 + staining was greater in the model group(35.2%,P≤0.001) than in controls or the SSd group(16.5%,P ≤ 0.001).The model group had more intense MMP-2 + staining than controls(0.37 vs 0.27,P≤0.01) or the SSd group(0.31 vs 0.37,P≤0.05);and higher MMP-13 + staining(72.55%) than in controls(12.55%,P≤0.001) and SSd group(20.18%,P≤0.01).The model group also had more TIMP-2 + staining(57.2%) than controls(20.9%,P≤0.001) and SSd group(22.7%,P≤0.001).Controls and SSd group showed no difference in TIMP-2 + rates.CONCLUSION:SSd inhibited HCC development,and downregulated expression of syndecan-2,MMP-2,MMP-13 and TIMP-2 in rat HCC liver tissue. | Xiaoli Jia Shuangsuo Dang Yanan Cheng Xin Zhang Mei Li Yaping Li Siyuan Li | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 12 |
| 9 | Theoretical and experimental investigation on a liquid-gas ejector power cycle using ammonia-water显示文摘The purpose of this paper is to investigate a novel power cycle using low-temperature heat sources such as oceanic-thermal, biomass as well as industrial waste heat. Both a reheater and a liquid-gas ejector are used in this ammonia-water based cycle. Energy analysis and parametric analysis are performed to guide the theoretical performance and experimental investigation is done to verify the theoretical results. The results show that the generator pressure, heating source temperature and turbine outlet depressurization made by the ejector can affect the cycle performances. Besides, the experimental thermal efficiency is much lower than the theoretical one on account of the heat losses and irreversibility. Moreover, the performance of liquid-gas ejector is affected by primary flow pressure and temperature. | YUAN Han MEI Ning LI Yan YANG Shuai HU SiYuan HAN YiFang | 2013 | Science China(Technological Sciences)2013，56，9： | 10 |
| 10 | Changes of Vertical Groundwater Recharge with Increase in Thickness of Vadose Zone Simulated by One-Dimensional Variably Saturated Flow Model显示文摘The thickness of vadose zone plays a critical role in vertical groundwater recharge. The decline of water table since the past decades due to long-term groundwater over-exploitation has resulted in deep vadose zone in North China Plain. One-dimensional variably saturated flow models were established by Hydrus-1D software and simulations were run under steady and continuous declining water table respectively to estimate the impact of increase in thickness of vadose zone on recharge process, quantity and recharge time. Luancheng area was selected to estimate recharge quantity considering steady and continuous declining water table. The simulation results show that the increase in thickness of vadose zone delays recharge process to water table. The recharge quantity decreases first and then remains stable with the decline of water table. Under the condition of declining water table, the evaluation of recharge by the flux at water table overestimates the recharge quantity. The average annual recharge rate of Luancheng area is 134 mm/a. | Siyuan Huo Menggui Jin Xing Liang Dan Lin | 2014 | Journal of Earth Science2014，25，6： | 10 |
| 11 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 12 | Active velocity tomography for assessing rock burst hazards in a kilometer deep mine显示文摘Active velocity tomography was used to determine the stress state and rock burst hazards in a deep coal mine. The deepest longwall face, number 3207 in the Xingcun colliery, was the location of the field trials. The positive correlation between stress and seismic velocity was used to link the velocity data with stratum stresses. A GeoPen SE2404NT data acquisition system was used to collect seismic data from 300 g explosive charges fired by instantaneous electric detonator and located in the tail entry. The geophones were installed on the rock bolts in the head entry of LW3207. Velocity inversion shows an inhomogeneous distribution of stress in the longwall face that could not be obtained from theory or numerical simulations. Three abnormally high P-wave velocity regions were identified that were located on the corners of the two roadways and at the face end near the rail entry side. The maximum velocity gradient is located at the open cut off near the rail entry and is the area most dangerous for rock burst. Mining-induced tremors recorded by a micro-seismic monitoring system demonstrated that the position of energy release during mining coincides with the high velocity gradient area. This technology aids tech- nicians in the coal mine as they design measures to weaken or eliminate potential danger during subse- quent mining. | He Hu Dou Linming Li Xuwei Qiao Qiuqiu Chen Tongjun Gong Siyuan | 2011 | Mining Science and Technology2011，21，5： | 9 |
| 13 | Preparation and properties of temperature sensitive paint based on Eu(DBM)_3 phen as probe molecule显示文摘Probe molecule Eu(DBM)3 phen is made up of europium oxide(Eu_2 O_3),dibenzoylmethane(DBM) and1,10-phenanthroline(phen). The temperature sensitive paint(TSP) was compounded by the polymerization of the probe molecule, methyl methacrylate(MMA) and the initiator of benzoyl peroxide(BPO).The structure, morphology, luminescence property of probe molecule and the temperature quenching property of the temperature sensitive paint(TSP) were characterized by infrared spectrometer, UV-vis spectrometer, scanning electron microscopy and fluorescence spectrometer respectively. The infrared spectrum and UV-vis spectra show that Eu and DBM form six membered rings, and Eu-O coordinate bonds form. The nanocrystals are in sphere-like morphology with an average size of approximately100 nm. Fluorescence spectra present that the performance of temperature quenching is excellent,what's more, TSP sample has different temperature sensitivity in various temperature scope. Particularly,under excitation of 286 nm, TSP has a highest temperature sensitivity between 50 and 60 ℃, and the strongest fluorescence emission reaches a peak(615 nm). It indicated that probe molecule(Eu(DBM)_3 phen) has strong luminescent intensity and the temperature quenching properties of Eu(DBM)_3 phen/PMMA is good. | Siyu Lu Jing Sun Yuan Wang Wensheng Yu Mengting Sun Siyuan Cui | 2018 | Journal of Rare Earths2018，36，6： | 8 |
| 14 | Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses显示文摘Hematopoietic stem cells(HSCs)in adults are believed to be born from hemogenic endothelial cells(HECs)in mid-gestational embryos.Due to the rare and transient nature,the HSC-competent HECs have never been stringently identified and accurately captured,let alone their genuine vascular precursors.Here,we first used high-precision single-cell transcriptomics to unbiasedly examine the relevant EC populations at continuous developmental stages with intervals of 0.5 days from embryonic day(E)9.5 to E11.0.As a consequence,we transcriptomically identified two molecularly different arterial EC populations and putative HSCprimed HECs,whose number peaked at El 0.0 and sharply decreased thereafter,in the dorsal aorta of the aorta-gonadmesonephros(AGM)region.Combining computational prediction and in vivo functional validation,we precisely captured HSCcompetent HECs by the newly constructed Neurl3-EGFP reporter mouse model,and realized the enrichment further by a combination of surface markers(Procr+Kit+CD44+,PK44).Surprisingly,the endothelial-hematopoietic dual potential was rarely but reliably witnessed in the cultures of single HECs.Noteworthy,primitive vascular ECs from E8.0 experienced two-step fate choices to become HSC-primed HECs,namely an Initial arterial fate choice followed by a hemogenic fate conversion.This finding resolves several previously observed contradictions.Taken together,comprehensive understanding of endothelial evolutions and molecular programs underlying HSC-primed HEC specification in vivo will facilitate future investigations directing HSC production in vitro. | Siyuan Hou Zongcheng Li Xiaona Zheng Yun Gao Ji Dong Yanli Ni Xiaobo Wang Yunqiao Li Xiaochen Ding Zhilin Chang Shuaili Li Yuqiong Hu Xiaoying Fan Yu Hou Lu Wen Bing Liu Fuchou Tang Yu Lan | 2020 | Cell Research2020，30，5： | 8 |
| 15 | Mode-division multiplexed transmission of wavelength-division multiplexing signals over a 100-km single-span orbital angular momentum fiber显示文摘We experimentally demonstrate mode-division multiplexed(MDM)transmission using eight orbital angular momentum(OAM)modes over a single span of 100-km low-attenuation and low-crosstalk ring-core fiber(RCF).Each OAM mode channel carries 10 wavelength-division multiplexing(WDM)signal channels in the C band,with each WDM channel in turn transmitting 16-GBaud quadrature phase-shift keying signal.An aggregate capacity of 2.56 Tbit/s and an overall spectral efficiency of 10.24 bit/(s·Hz)are realized.The capacity-distance product of 256(Tbit/s)·km is the largest reported so far for OAM fiber communications systems to the best of our knowledge.Exploiting the low crosstalk between the OAM mode groups in the RCF,the scheme only requires the use of modular 4×4 multiple-input multiple-output processing,and it can therefore be scaled up in the number of MDM channels without increasing the complexity of signal processing. | Junwei Zhang Junyi Liu Lei Shen Lei Zhang Jie Luo Jie Liu Siyuan Yu | 2020 | Photonics Research2020，8，7： | 8 |
| 16 | Epigenetic regulation of macrophages: from homeostasis maintenance to host defense显示文摘Macrophages are crucial members of the innate immune response and important regulators.The differentiation and activation of macrophages require the timely regulation of gene expression,which depends on the interaction of a variety of factors,including transcription factors and epigenetic modifications.Epigenetic changes also give macrophages the ability to switch rapidly between cellular programs,indicating the ability of epigenetic mechanisms to affect phenotype plasticity.In this review,we focus on key epigenetic events associated with macrophage fate,highlighting events related to the maintenance of tissue homeostasis,responses to different stimuli and the formation of innate immune memory.Further understanding of the epigenetic regulation of macrophages will be helpful for maintaining tissue integrity,preventing chronic inflammatory diseases and developing therapies to enhance host defense. | Siyuan Chen Jing Yang Yuquan Wei Xiawei Wei | 2020 | Cellular & Molecular Immunology2020，17，1： | 8 |
| 17 | Estimating source strengths of HCl and SO_2 emissions in the flue gas from waste incineration显示文摘HCl and SO_2 emission is one of the major concerns related to municipal solid waste incinerator(MSWI). In this study, a material flow analysis model was developed to estimate the HCl and SO_2 concentrations in the MSWI flue gases(FGs), and their concentrations in the full-scale MSWI were monitored. The calculated concentrations of HCl and SO_2 in the FG were 770–1300 mg/Nm^3 and 150–640 mg/Nm^3, respectively, in close agreement with the monitored values. More than 99% of Cl and 92% of S from the FG were captured into solid residues by the air pollution control(APC) systems. Moreover, since only 48.4%–67.5% of Cl and 21.3%–53.4% of S were transferred to the FG from the municipal solid waste(MSW), it was more reliable to estimate the source strengths and release amounts of HCl and SO_2 in the FG based on the amounts of Cl and S in the APC residues(AR) and exhaust gas rather than in the MSW. This simple method is easily applicable and the estimated results could provide scientific basis for the appropriate design and operation of the APC systems as well as corrosion control of heat recovery systems. | Hua Zhang Siyuan Yu Liming Shao Pinjing He | 2019 | Journal of Environmental Sciences2019，31，1： | 7 |
| 18 | Low-noise 1.3 μm InAs/GaAs quantum dot laser monolithically grown on silicon显示文摘We report low-noise, high-performance single transverse mode 1.3 μm InAs/GaAs quantum dot lasers monolithically grown on silicon(Si) using molecular beam epitaxy. The fabricated narrow-ridge-waveguide Fabry–Perot(FP) lasers have achieved a room-temperature continuous-wave(CW) threshold current of 12.5 mA and high CW temperature tolerance up to 90°C. An ultra-low relative intensity noise of less than-150 dB∕Hz is measured in the 4–16 GHz range. Using this low-noise Si-based laser, we then demonstrate 25.6 Gb/s data transmission over13.5 km SMF-28. These low-cost FP laser devices are promising candidates to provide cost-effective solutions for use in uncooled Si photonics transmitters in inter/hyper data centers and metropolitan data links. | MENGYA LIAO SIMING CHEN ZHIXIN LIU YI WANG LALITHA PONNAMPALAM ZICHUAN ZHOU JIANG WU MINGCHU TANG SAMUEL SHUTTS ZIZHUO LIU PETER M.SMOWTON SIYUAN YU ALWYN SEEDS HUIYUN LIU | 2018 | Photonics Research2018，，11： | 7 |
| 19 | Average temperature calculation for straight single-row-piped frozen soil wall显示文摘The average temperature of frozen soil wall is an essential parameter in the process of design,construction,and safety management of artificial ground freezing engineering.It is the basis of calculating frozen soil's mechanical parameters,further prediction of bearing capacity and,ultimately,safety evaluation of the frozen soil wall.Regarding the average temperature of single-row-piped frozen soil wall,this paper summarizes several current calculation methods and their shortcomings.Furthermore,on the basis of Bakholdin's analytical solution for the temperature field under straight single-row-piped freezing,two new calculation models,namely,the equivalent trapezoid model and the equivalent triangle model,are proposed.These two approaches are used to calculate the average temperature of a certain cross section which indicates the condition of the whole frozen soil wall.Considering the possible parameter range according to the freezing pipe layout that might be applied in actual construction,this paper compares the average temperatures of frozen soil walls obtained by the equivalent trapezoid method and the equivalent triangle method with that obtained by numerical integration of Bakholdin's analytical solution.The results show that the discrepancies are extremely small and these two new approaches are better than currently prevailing methods.However,the equivalent triangle method boasts higher accuracy and a simpler formula compared with the equivalent trapezoid method. | XiangDong Hu SiYuan She RuiZhi Yu | 2011 | Research in Cold and Arid Regions2011，3，2： | 7 |
| 20 | Applicability of Two Newmark Models in the Assessment of Coseismic Landslide Hazard and Estimation of Slope-Failure Probability: An Example of the 2008 Wenchuan M_w 7.9 Earthquake Affected Area显示文摘This paper presents the landslide hazard assessment and slope-failure function using two Newmark displacement models regressed by regional and global station records. Taking the 2008 Wenchuan M_w 7.9 earthquake area as an example, based on the topographic and geological data of the study area, we prepared a factor-of-safety(Fs) map and a critical acceleration(ac) map, respectively. Then using these two simplified Newmark models, two displacement maps were compiled by combining the ac map and peak ground acceleration(PGA) map. By virtue of the actual landslide inventory of the Wenchuan earthquake, we constructed the slope-failure probability curves of the two Newmark models. The results show that the abilities to predict landslide occurrence of the two simplified Newmark models are largely identical, by which the assessment results can well delineate the macroscopic distribution of coseismic landslides, and most predicted landslide cells are distributed on the two sides of the Beichuan-Yingxiu fault, especially Pengguan complex rock mass in the hanging wall of this fault. The probability equations of two Newmark models are roughly the same, though the parameters vary slightly. The probability equation proposed in this paper can be applied to the Wenchuan region and other areas with similar tectonic environments. | Siyuan Ma Chong Xu | 2019 | Journal of Earth Science2019，30，5： | 7 |
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