|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases显示文摘Alcoholic liver disease is a major health problem in the United States and worldwide. Chronic alcohol consumption can cause steatosis, inflammation, fibrosis, cirrhosis and even liver cancer. Significant progress has been made to understand key events and molecular players for the onset and progression of alcoholic liver disease from both experimental and clinical alcohol studies. No successful treatments are currently available for treating alcoholic liver disease; therefore, development of novel pathophysiological-targeted therapies is urgently needed. This review summarizes the recent progress on animal models used to study alcoholic liver disease and the detrimental factors that contribute to alcoholic liver disease pathogenesis including miRNAs, S-adenosylmethionine, Zinc deficiency, cytosolic lipin-1β, IRF3-mediated apoptosis, RIP3-mediated necrosis and hepcidin. In addition, we summarize emerging adaptive protective effects induced by alcohol to attenuate alcohol-induced liver pathogenesis including FoxO3, IL-22, autophagy and nuclear lipin-1α. | Jessica A Williams Sharon Manley Wen-Xing Ding | 2014 | World Journal of Gastroenterology2014，20，36： | 10 |
| 2 | 多元PCR在黑鲍(Haliotis rubra)微卫星遗传研究中的应用显示文摘根据D03等11个微卫星引物单位点PCR扩增时优化的扩增条件(退火温度、MgCl2等)和11个微卫星引物所带有的荧光颜色、等位基因大小变异范围及反应的灵敏度,可将11个微卫星引物分成A组(D03、G04、B04和H08)、B组(A09、H11、A08和G01)和C组(CmrHr1.24、CmrHr2.30和CmrHr2.23)进行多元PCR扩增,结果显示各组内位点之间的分离清晰,这表明多元PCR可以大大提高微卫星检测仪器的使用效率和提高实验效果,在微卫星研究中是一种快速便捷的方法。 | 黎中宝 Appleyard Sharon A Elliott Nicholas G | 2005 | 海洋与湖沼2005，36，4： | 8 |
| 3 | Immunological battlefield in gastric cancer and role of immunotherapies显示文摘Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an 'us against them' model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy – the tumour cell. | Minyu Wang Rita A Busuttil Sharon Pattison Paul J Neeson Alex Boussioutas | 2016 | World Journal of Gastroenterology2016，22，28： | 4 |
| 4 | Switching barriers and repurchase intentions in services显示文摘 | Michael A Jones David L Mothersbaugh Sharon E Beatty | 2000 | Journal of Retailing2000，，2： | 2 |
| 5 | Fostering technology transfer through industry university cooperation: A practitioner's view at MIT 显示文摘 | Sharon A | 1994 | Empirica1994，，21： | 1 |
| 6 | Dietary genistein reduces metastasis in postsurgical orthotopic breast cancer model显示文摘 | Sharon A Vantyghem Sylvia M | 2005 | Cancer Res2005，65，8： | 1 |
| 7 | Why customers stay:measuring the underlying dimensions of services switching costs and managing their differential stra-tegic outcomes显示文摘 | Michael A J David L M Sharon E B | 2002 | Journal of Business Research2002，55，6： | 1 |
| 8 | Ralf Conrad Cold-temperate climate: a factor for selection of ammonia oxidizers in upland soil显示文摘 | Sharon A | 2005 | Canadian Journal of Microbiology2005，51，： | 1 |
| 9 | Estimating the prevalence, incidence and cessation of injecting drug use in Glasgow 1960 - 2000 : Combining expert opinion with capture - recapture prevalence data显示文摘 | SHARON J HUTCHINSON S M BIRD A T | 2006 | J Drug Policy2006，17，： | 1 |
| 10 | How Do Entrepreneurs Organize Firms Under Conditions of Uncertainty? 显示文摘 | Sharon A Alvarez Jay B Barney | 2005 | Journal of Management2005，31，5： | 1 |
| 11 | Fungal peritonitis caused by Lecythophora mutabilis显示文摘 | Suhail A Richard JJ Sharon H | 1985 | J Clin Microbiol1985，，22： | 1 |
| 12 | To buy or to borrow, that is the question显示文摘 | Sharon A Campbell | 2006 | Journal of Interlibrary Loan Document Delivery & Electronic Reserve2006，16，3： | 1 |
| 13 | Effects of temperature and fertilizer on activity and community structure of soil ammonia oxidizers显示文摘 | Sharon A Werner L Ralf C | 2003 | Environmental Microbiology2003，5，8： | 1 |
| 14 | Msf-a interacts with hypoxia-inducible factor-1and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis显示文摘 | Sharon A Wang R Matzkin H | 2006 | Cancer Research2006，，66： | 1 |
| 15 | Macro/micro manipulator: An improved architecture for robot control显示文摘 | SHARON A HOGAN N HARDT D E | 1993 | Robotics and Computer-Integrated Manufacturing1993，10，3： | 1 |
| 16 | Susceptibility of Neisseria meningitidis to 16 Antimicrobial Agents and Characterization of Resistance Mechanisms Affecting Some Agents显示文摘 | James H Jorgensen Sharon A Crawford | 2005 | J Clin Microbiol2005，43，： | 1 |
| 17 | Alkaline fuel cell:carbon nanobeads coated with metal catalyst over porous ceramic for hydrogen electrode显示文摘 | Chatterjee A K Sharon M Banerjee R | 2003 | J Power Sources2003，117，12： | 1 |
| 18 | The distribution of wind - driven rainfall in a small valley: an empirical basis for numerical model verification显示文摘 | Sharon D Arazi A | 1997 | Hydrol1997，201，： | 1 |
| 19 | Forage type and fish oio cause shifts in rumen bac- terial diversity 显示文摘 | Sharon A Huws | 2010 | FEMS Microbiol Ecology2010，73，： | 1 |
| 20 | ACC/AHA guidelines : A-, B-, C-, and D-based approach to chronic heart failure therapy 显示文摘 | Sharon A | 2006 | Eur Heart J Suppl2006，8，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员