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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Numerical simulation to relate the shot peening parameters to the induced residual stresses显示文摘 | HONG T OOI J Y SHAW B | 2008 | Engineering Failure Analysis2008，，15： | 1 |
| 3 | Entecavir for the treatment of chronic hepatitis B 显示文摘 | Shaw T Locarnini S | 2004 | Expert Rev Anti Infect Ther2004，2，6： | 1 |
| 4 | Antiviral drug resistance in hepatitis B andC显示文摘 | Locarnini SA Shaw T | 2004 | J Gastroentero Hepatol2004，19，32： | 1 |
| 5 | Do early quadriceps exercis- es affect the outcome of ACL reconstruction? A randomized con- trolled trial显示文摘 | Shaw T Williams MT Chipchase LS | 2005 | Aust J Physiother2005，51，1： | 1 |
| 6 | Immunosuppressive drugs prevent a rapid dephos?phorylation of transcription factor NF A Tl in stimulated immune cells显示文摘 | SHAW K T Y HO A M RAGHAVAN A | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 7 | Translation of ' Onegin' 显示文摘 | Shaw T | 1965 | Russian Review1965，，2： | 1 |
| 8 | 显示文摘 | Chen Yan Shaw D T Guo Liping | 2000 | Applied Physics Letters2000，76，17： | 1 |
| 9 | Endogenous on cogenic K-ras (G12D) stimulates proliferation and widespread neoplastic and developmental defects 显示文摘 | Tuveson D A Shaw A T Willis N A | 2004 | Cancer Cell2004，5，4： | 1 |
| 10 | Enteeavir for the treatment of chronic hepatitis B显示文摘 | Shaw T Locamini S | 2004 | Expert Rev Anti Infecter2004，，2： | 1 |
| 11 | 显示文摘 | Shaw T M Suo Z Huang M | 1999 | Appl Phys Lett1999，75，： | 1 |
| 12 | Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation 显示文摘 | Delaney WE Locamini S Shaw T | 2001 | Antivir Chem Chemother2001，12，1： | 1 |
| 13 | Investigating learner vocabulary: A possible approach to looking at EFIJESL learners'qualitative knowledge of the word显示文摘 | LIU T K E SHAW M P | 2001 | IRAL2001，，39： | 1 |
| 14 | Iniatial validation of a diagnostic questionnaire for gastroesophageal reflux disease 显示文摘 | Shaw M J Talley N J Beebe T J | 2001 | Am J Gastroenterol2001，96，1： | 1 |
| 15 | Using actual andcontingent behavior data with differing levels of time aggregation to modelrecreation demand显示文摘 | CAMERON T A SHAW W D RAGLAND S E | 1996 | Journal of Agricultural and Resource Economics1996，21，： | 1 |
| 16 | Effect ofcrizotinib on overall survival in patients with advancednon-small-cell lung cancer harbouring ALK generearrangement:a retrospective analysis 显示文摘 | Shaw A T Yeap B Y Solomon B J | 2011 | Lancet Oncol2011，12，11： | 1 |
| 17 | Protection from IBDV-induced bursal damage by a recombinant fowlpox vaccine, fpIBD1, is dependent on the titre of challenge virus and chicken genotype显示文摘 | SHAW I DAVISON T F | 2000 | Vaccine2000，18，28： | 1 |
| 18 | 显示文摘 | Shaw T Locamini SA | 1999 | J Viral Hepat1999，6，2： | 1 |
| 19 | Stability of mycophenolic acid in plasma samples from patients during mycophenolate mofetil therapy显示文摘 | Pawinski T Shaw LM | 2003 | Acta Pol Pharm2003，60，2： | 1 |
| 20 | Knee pain after intramedullary tibial nailing:its incidence,etiology,and outcome显示文摘 | Court-Brown CM Gustilo T Shaw AD | 1997 | J Orthop Trauma1997，11，2： | 1 |
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