|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease显示文摘Atrial fibrillation(AF) is the most common type of sustained arrhythmia,which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes it a major healthcare burden. The objective of our article is to determine the prognostic impact of AF on acute coronary syndromes,heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that AF has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease. | Nileshkumar J Patel Aashay Patel Kanishk Agnihotri Dhaval Pau Samir Patel Badal Thakkar Nikhil Nalluri Deepak Asti Ritesh Kanotra Sabeeda Kadavath Shilpkumar Arora Nilay Patel Achint Patel Azfar Sheikh Neil Patel Apurva O Badheka Abhishek Deshmukh Hakan Paydak Juan Viles-Gonzalez | 2015 | World Journal of Cardiology2015，7，7： | 2 |
| 2 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 3 | Spacecraft Navigation Using X-ray Pulsars 显示文摘 | Sheikh S I Pines D J Ray P S | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 4 | Hepatitis C virus infection: molecular pathways to metabolic syndrome 显示文摘 | Sheikh MY Choi J Qadri I | 2008 | Hepatology2008，47，6： | 1 |
| 5 | Quantitative biofihn assay using a microtiter plate to screen for enteroaggregative Escherichia coli 显示文摘 | Wakimoto N Nishi J Sheikh J | 2004 | Am J Trop Med Hyg2004，71，5： | 1 |
| 6 | Effect of hyperoxia on vascular endothelial growth factor levels in a wound model显示文摘 | Sheikh A Y Gibson J J Rollins M D | 2000 | Arch Surg2000，135，11： | 1 |
| 7 | Chronic obstructive pulmonary disease,asthma,and risk of type 2 diabetes in women显示文摘 | Rana JS Mittleman MA Sheikh J | | 0，，10： | 1 |
| 8 | Percutaneous coblation nucleoplasty in patients with contained lumbar disc pro- lapse: 1 year follow-up in a prospective case series 显示文摘 | Sinan T Sheikh M Burie J | 2011 | Acta Neurochir Suppl2011，108，： | 1 |
| 9 | Spacecraft navigation using X-ray pulsars显示文摘 | Sheikh S I Pines D J | 2006 | Journal of Guidance Control and Dynamics2006，29，1： | 1 |
| 10 | A novel dispersin protein in enteroaggregative Escherichia coli显示文摘 | Sheikh J Czeczulin JR HaITington S | 2002 | J Clin Invest2002，110，9： | 1 |
| 11 | Quantitive biofilm assay using a microtiterplate to screen for enteroaggregative Escherichia coli 显示文摘 | WAKIMOTO N NISHI J SHEIKH J | 2004 | Am J Trop Med Hyg2004，71，： | 1 |
| 12 | Beam-column moment connections for composite frames:part 1显示文摘 | Sheikh T M Deierlein G G Yura J A | 1989 | Journal of Structural Engineering1989，115，11： | 1 |
| 13 | Finite element simulation of the hip joint during stumbling:A comparison between static and dynamic loading显示文摘 | El′Sheikh H F MacDonald B J Hashmi M S J | 2003 | Mater proc Techn2003，，1： | 1 |
| 14 | Role of p53 family members in apoptosis 显示文摘 | Sheikh M S Fornace Jr A J | 2000 | Journal of Cellular Physiology2000，182，： | 1 |
| 15 | Multi- quasiparticle potential-energy surfaces显示文摘 | Xu F R Walker P M Sheikh J A | 1998 | Physics Letter B1998，435，34： | 1 |
| 16 | Percutaneous coblation nucleoplasty in patients with contained lumbar disc prolapse: 1 year follow-up in a prospective case series显示文摘 | Sinan T Sheikh M Buric J | 2011 | Acta Neurochir Suppl2011，108，： | 1 |
| 17 | Beam-column moment connections for composite frames:part 2显示文摘 | Deierlein G G Sheikh T M Yura J A | 1989 | Journal of Structural Engineering1989，115，11： | 1 |
| 18 | Numerical evaluation of the behavior of steel and FRP confined concrete columns using compression field modeling显示文摘 | Montoya E Vecchio F J Sheikh S A | 2004 | Engineering Structures2004，26，11： | 1 |
| 19 | Complications/problems of colostomy in infants and children显示文摘 | Sheikh MA Akhtar J Ahmed S | 2006 | J Coil Physicians Surg Pak2006，16，8： | 1 |
| 20 | In vivo genetic profiling and cellular localization of Apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure 显示文摘 | Sheikh AY Chun HI Glassford A J | 2008 | Am J Physiol Heart Circ Physiol2008，294，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员