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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Regulatory effect and mechanism of gastrin and its antagonists on colorectal carcinoma显示文摘AIM To explore the effect and mechanism ofgastrin and its antagonists proglumide and somatostatin on coIorectal carcinoma and their clinical significance.METHODS A model of transplanted human colonic carcinoma was established from SW480cell line in gymnomouse body. The volume andweight of transplanted carcinoma was observedunder the effect of pentagatrin (PG), proglumide (PGL) and octapeptide somotostatin (SMS201-995, SMS). The cAMP content ot carcinoma cell was determined by redioimmunoassay and the DNA, protein content and cell cycle were determined by flow-cytometry. The amount of viabIe cells was determined by MTT colorimetric analysis, lP3 content was determined by radioimmunoassay, Ca2+ concentration in cell by fluorometry and PKC activity by isotopic enzymolysis. The expression of gastrin, c-myc,C-fos and rasP21 in 48 cases of colorectal carcinoma tissue was detected by the immunocytochemistry SP method. Argyrophilianucleolar organizer regions was determined withargyrophilia stain.RESULTS The volume, weight, cAMP, DNAand protein content in carcinoma cell, cellamount and proliferation index of S and G2Mphase in PG group were all significantly higher than those of control group. When PG was at theconcentration of 25 mg/ L, the amount of viablecells, lP3 content and Ca2+ concentration in celland membrane PKC activity in PG group weresigniticantly higher than those in control group;when PGL was at a concentration ot 32 mg/L,they dropped to the lowest level in PG (25 mg/L)+ PGL group, but without significant differencefrom the control group. The positive expression rate of gastrin, c-myc, c-fos and rasp21 in carcinoma tissue was 39 .6%, 54 .2%, 47. 9% and54 .2% resPectively and significantly higher than that in mucosa 3 cm and 6 cm adjacent tocarcinoma tissue and normal colorectal mucosa.The positive expression rate of gastrin of highlydifferentiated adenocarcinoma group was significantly higher than that of poorly differentiated and mucinous adenocarcinoma groups. The AgNORs count of carcinoma tissue was significantly higher than that in mucosa 3 cm and 6 cm adjacent to carcinoma tissue and normal colorectal mucosa; and the positive expression of c-myc and c-fos and the AgNORs count in gastrin-positive group was significantly higher than those in gastrin-negative group.CONCLUSION Pentagastrin has a promoting effect on the growth of transplanted human colonic carcinoma from SW480 cell line. PGL hasno obvious effect on the growth of human colonic carcinoma SW480 cell line, but couldinhibit the growth-promoting effect of PG on transplanted carcinoma. Somatostatin can not only inhibit the growth of transplanted human colonic carcinoma from SW480 cell line directlybut also depress the growth-promoting effect ofgastrin on the transplanted carcinoma. Somecolorectal carcinoma cells can produce and secrete gastrin through autocrine, highly-differentiated adenocarcinoma express the highest level gastrin. Endogenous gastrin can stimulate the cell division and proliferation of carcinoma cell and promote the growth of colorectal carcinoma regulating the expression of oncogene omyc, c-fos. Our study has provided experimental basis for the adjuvant treatment using gastrin antagonist such as PGL,somatostatin of patients with colorectalcarcinoma. | He SW Shen KQ He YJ Xie B Zhao YM | 1999 | World Journal of Gastroenterology1999，5，5： | 20 |
| 3 | Step Sintering of Microwave Heating and MicrowavePlasma Heating for Alumina Ceramics显示文摘The invention of microwave induced plasma during microwave heating makes it possible to confine plasma inside a crucible, in the pressure range of 1.33 Pa to 0.5 MPa, and above 900℃.In this study, the step sintering of microwave heating and microwave plasma heating (SSMP)was proposed. In this process, microwave heating and plasma heating was ingeniously combined in one chamber, and vacuum was unnecessary for microwave induced plasma. In the first step, the microwave energy directly heated alumina ceramics to a given temperature. above which microwave will mainly ionize the gas and sustain a plasma. Then the plasma further heated alumina ceramics to the final temperature to finish sintering. Maintaining the advantages of microwave heating and plasma heating, this step sintering approach will overcome the limitation of both processes for processing ceramics. and it will be suitable for sintering all kinds of ceramics in | Zhang, JS Cao, L Yang, YJ Diao, YX Shen, XX | 1999 | Journal of Materials Science & Technology1999，15，5： | 2 |
| 4 | Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: pathogenetie and molecular links显示文摘 | Truong LD Choi YJ Shen SS | 2003 | Adv Anat Pathol2003，10，13： | 1 |
| 5 | Effects of brain histamine on memorydeficit induced by nucleus basalis- 1esion in rats显示文摘 | Chen Z Shen YJ | 2002 | ActaPharmacol Sin2002，23，1： | 1 |
| 6 | Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA显示文摘 | Zhang YJ Wu HC Shen J | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 7 | Role of interleukin- 18 in acute lung inflammation induced by gut ischemia reperfusion 显示文摘 | Yang YJ Shen Y Chen SH | 2005 | World J Gastroenterol2005，11，29： | 1 |
| 8 | Current research in perineu- ral invasion of cholangioeareinoma显示文摘 | Shen FZ Zhang BY Feng YJ | 2010 | J Exp Clin Cancer Res2010，29，10： | 1 |
| 9 | Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis显示文摘 | Chen YJ Shen JL Wu CY | 2009 | J Am Acad Dermatol2009，60，2： | 1 |
| 10 | Distinct roles of myeloid and plasmacytoid dendritic cells in systemic lupus erythematosus显示文摘 | Chan VS Nie YJ Shen N | 2012 | Autoimmun Rev2012，11，12： | 1 |
| 11 | Collagenase production is lower in post- bum hypertrophic scar fibroblasts and is reduced by insulin- like growth factor - l显示文摘 | Ghahary A Shen YJ Nedelec B | 1996 | J Invest Dermatol1996，106，3： | 1 |
| 12 | Expression and localization of insulin like growth factor 1 in normal and post burn hypertrophic scar tissue in human显示文摘 | GHAHARY A SHEN YJ WANG R | 1998 | Mol Cell Biochem1998，183，： | 1 |
| 13 | A link between the interleu- kin-6/Stat3 anti--apoptotic pathway and microRNA-21 in preim- plantation mouse embryos显示文摘 | Shen XH Han YJ Zhang DX | 2009 | Mol Reprod2009，76，9： | 1 |
| 14 | Exercise preconditioning-in-duced late phase of cardio protection against exhaustive exer-cise: possible role of protein kinase C delta 显示文摘 | HaoZ Pan SS Shen YJ | 2014 | J PhysiolSci2014，64，5： | 1 |
| 15 | Effects of shade treatments on the photosynthetic capacity, chlorophyll fluoreeeence, and chlorophyll content of Tetrastigma hemsleyanum Dies et Gilg 显示文摘 | Dai YJ Shen ZC Liu Y | 2009 | Enviromental and Experimental Botany2009，65，17： | 1 |
| 16 | Predicting factors of malignancy in dermatomyositis and polymyositis:a case-control study显示文摘 | Chen YJ Wu CY Shen JL | 2001 | Br J Dermatol2001，144，4： | 1 |
| 17 | Mechanically assisted intraarte- rial throm-bolysis in acute cerebral infarction显示文摘 | Wang HX Shen YJ Ye SJ | 2013 | Exp Ther Med2013，5，5： | 1 |
| 18 | Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissues显示文摘 | Ghahary A Shen YJ Scott PG | 1995 | Cytokine1995，7，2： | 1 |
| 19 | Predicting factors of malignant in dermatomyositis and polymyositis: a case-control study 显示文摘 | Chen YJ Wa CY Shen JL | 2001 | Br J Dermatol2001，144，4： | 1 |
| 20 | Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats 显示文摘 | Chen ZH Shen YJ | 2002 | Acta Phamacol Sin2002，23，2： | 1 |
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