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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair显示文摘Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neovascularization and neurogenesis, and potential signaling involved therein, are unclear. Here, we established a primary spinal cord-derived MECs (SCMECs) isolation with high cell yield and purity to describe the differences with brain-derived MECs (BMECs) and their therapeutic effects on SCI. Transcriptomics and proteomics revealed differentially expressed genes and proteins in SCMECs were involved in angiogenesis, immunity, metabolism, and cell adhesion molecular signaling was the only signaling pathway enriched of top 10 in differentially expressed genes and proteins KEGG analysis. SCMECs and BMECs could be induced angiogenesis by different stiffness stimulation of PEG hydrogels with elastic modulus 50-1650 Pa for SCMECs and 50-300 Pa for BMECs, respectively. Moreover, SCMECs and BMECs promoted spinal cord or brain-derived NSC (SNSC/BNSC) proliferation, migration, and differentiation at different levels. At certain dose, SCMECs in combination with the NeuroRegen scaffold, showed higher effectiveness in the promotion of vascular reconstruction. The potential underlying mechanism of this phenomenon may through VEGF/AKT/eNOS- signaling pathway, and consequently accelerated neuronal regeneration and functional recovery of SCI rats compared to BMECs. Our findings suggested a promising role of SCMECs in restoring vascularization and neural regeneration. | Zhifeng You Xu Gao Xinyi Kang Wen Yang Tiandi Xiong Yue Li Feng Wei Yan Zhuang Ting Zhang Yifu Sun He Shen Jianwu Dai | 2023 | Bioactive Materials2023，，11： | 2 |
| 3 | A feasibility research on friction stir welding of a new-typed lap-butt joint of dissimilar A1 alloys 显示文摘 | Li Bo Shen Yifu | 2012 | Materials and Design2012，，34： | 1 |
| 4 | Casting defects induced fatigue damage in aircraft frames of ZL205A aluminum alloy – A failure analysis显示文摘 | Bo Li Yifu Shen Weiye Hu | 2011 | Materials and Design2011，，5： | 1 |
| 5 | Preparation of TiN-Ti5Si3 in-situ composites by Selective Laser Melting显示文摘 | Dongdong Gu Yifu Shen Zhijian Lu | 2009 | Materials Letters2009，63，： | 1 |
| 6 | The technology and welding joint properties of hybrid laser-tig welding on thick plate显示文摘 | Zhang Shenghai Shen Yifu Qiu Huijuan | 2013 | Optics and Laser Technology2013，，： | 1 |
| 7 | Balling phenomena during direct laser sintering of multi-component Cu-based metal powder显示文摘 | Dongdong Gu Yifu Shen | 2006 | Journal of Alloys and Compounds2006，，1： | 1 |
| 8 | Materials and Design显示文摘 | Li Bo Shen Yifu Hu Weiye | 2011 | 32:25702011，32，： | 1 |
| 9 | Casting defects fatigue damage in aircraft frames of ZL205A aluminum alloy-A failure analysis显示文摘 | Li Bo Shen Yifu Hu Weiye | 2011 | Materials and Design2011，，32： | 1 |
| 10 | Casting defects induced fatigue damage in aircraft frames of ZL205A aluminum alloy-a failure analysis显示文摘 | Li Bo Shen Yifu Hu Weiye | 2011 | Materials and Design2011，32，5： | 1 |
| 11 | Influence of processing parameters on particulate dispersion in direct laser sintered WC-Cop/Cu MMCs显示文摘 | Gu Dongdong Shen yifu | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，5： | 1 |
| 12 | Study on properties ofSn-9Zn-Ga solder bearing Nd 显示文摘 | Xue Peng Xue Songbai Shen Yifu et al | 2012 | Journal of Materials ScienceMaterials Electronics2012，23，： | 1 |
| 13 | Growth morphologies and mechanisms of TiC grains during Selective Laser Melting of Ti–Al–C composite powder显示文摘 | Dongdong Gu Yifu Shen Guangbin Meng | 2009 | Materials Letters2009，，29： | 1 |
| 14 | Dissimilar friction stir welding of Ti-6A1-4V alloy and aluminum alloy employing a modi- fied butt joint configuration : Influences of process variables on the weld interfaces and tensile properties 显示文摘 | Li Bo Zhang Zhenhua Shen Yifu | 2014 | Materials and Design2014，53，： | 1 |
| 15 | Influence of phosphorus element on direct laser sintering of multicomponent Cubased metal powder 显示文摘 | Gu Dongdong Shen Yifu | 2006 | Metallurgical and Materials Transactions B2006，37，6： | 1 |
| 16 | Formation of a novel W-rim/Cu-core structure during direct laser sintering of W-Cu composite system 显示文摘 | Dongdong Gu Yifu Shen Xiaojuan Wu | 2008 | Materials Letters2008，，62： | 1 |
| 17 | Effects of dispersion technique and component ratio on densification and microstructure of multi-component Cu-based metal powder in direct laser sintering 显示文摘 | Gu Dongdong Shen Yifu | 2007 | Journal of Materials Processing Technology2007，182，13： | 1 |
| 18 | Preparation of TiN-Tis Si3 in-situ composites by selective laser melting显示文摘 | Gu Dongdong Shen Yifu Lu Zhijian | 2009 | Materials Letters2009，63，1819： | 1 |
| 19 | Bailing phenonena in direct laser sintering of stainless steel powder 显示文摘 | Gu Dongdong Shen Yifu | 2009 | Metallurgical mechanisms and control methods Materials and Design2009，，30： | 1 |
| 20 | Study on properties of Sn-9 Zn-Ga solder bearing Nd显示文摘 | Xue Peng Xue Songbai Shen Yifu | 2012 | Journal of Materials Science- materials in Electronics2012，23，6： | 1 |
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