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| 1 | Hepatocellular carcinoma-specific immunotherapy with synthesized α1,3-galactosyl epitope-pulsed dendritic cells and cytokine-induced killer cells显示文摘AIM: To evaluate the safety and clinical efficacy of a new immunotherapy using both α-Gal epitope-pulsed dendritic cells (DCs) and cytokine-induced killer cells.METHODS: Freshly collected hepatocellular carcinoma(HCC) tumor tissues were incubated with a mixture of neuraminidase and recombinant α1,3-galactosyltransferase (α1,3GT) to synthesize α-Gal epitopes on carbohydrate chains of the glycoproteins of tumor membranes. The subsequent incubation of the processed membranes in the presence of human natural anti-Gal IgG resulted in the effective phagocytosis to the tumor membrane by DCs. Eighteen patients aged 38-78 years with stage Ⅲ primary HCC were randomLy chosen for the study; 9 patients served as controls, and 9 patients were enrolled in the study group.RESULTS: The evaluation demonstrated that the procedure was safe; no serious side effects or autoimmune diseases were observed. The therapy significantly prolonged the survival of treated patients as compared with the controls (17.1 ± 2.01 mo vs 10.1 ± 4.5 mo,P = 0.00121). After treatment, all patients in the study group had positive delayed hyper sensitivity and robust systemic cytotoxicity in response to tumor lysate as measured by interferon-γ-expression in peripheral blood mononuclear cells using enzyme-linked immunosorbent spot assay. They also displayed increased numbers of CD8-, CD45RO-and CD56-positive cells in the peripheral blood and decreased α-fetoprotein level in the serum.CONCLUSION: This new tumor-specific immunotherapy is safe, effective and has a great potential for the treatment of tumors. | Ying Qiu Ming-Bao Xu Mark M Yun Yi-Zhong Wang Rui-Ming Zhang Xing-Kai Meng Xiao-Hui Ou-Yang Sheng Yun | 2011 | World Journal of Gastroenterology2011，17，48： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Fluid Inclusion Geochemistry of Metallic Ore Deposits in the South- Central Sector of theDa Hinggan Mountains in China显示文摘Physicochemical parameters of mineralization such as temperature, pressure, salinity, density, composition and boiling of ore fluids as well as pH, Eh, fo2 and reducing parameter in theprocess of mineralization of major ore deposits in the study district have been obtained by the authors through systematic observation and determination of characteristics and phase changes of fluid inclusions at different temperatures and analysis of gaseous and liquid phase compositions of the inclusions, thus providing a scientific basis for the division of mineralization-alteration stages, types of mineral deposits and minerogenetic series and the deepening of the knowledge about the ore-forming processes and mechanisms of mineral deposits. It is indicated that the deposits of the same type have similar fluid inclusion geochemical features and physicochemical parameters though they belong to different minerogenetic series, while the compositions of inclusions are not conditioned by deposit types but closely related | Sheng Jifu, Zhang Dequan and Li YanInstitute of Mineral Deposits, Chinese Academy of Geological Sciences, Beijing Jiang M inxi | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 3 |
| 4 | SOURCE RADIATION AND RESPONSES OF WAVE PROPAGATION显示文摘Recordings of seismic waves propagating from earthquake source to a station at the earth’s surface are a system response function. The convolution operator in time domain can be simplified as a multiplication operator in frequency domain. We discuss in frequency domain the separation of source, path and site effects for global scaling of earthquake source radiation. Also discussed are source scaling model, faulting mechanism, and the H/V inversion problems with crustal and near surface structures. Gross features of apparent source spectra appear to be not much region dependent although there may be difference between tectonic styles within a region of tectonic mixture for which we need further study as data accumulate. Vertical spectra may be a better approach to approximate source radiation, as it has less crustal amplification effects than horizontal spectra. The H/V ratio is evidently a comprehensive indicator of amplification effects from near surface to deep structure. This gives it potential as an inversion tool to deduce site crustal structure. | CHEN Sheng zao 1 and Gail M Atkinson 2 (1. Geomatrix Consultants, Inc., 2101 Webster St., 12 th Floor, Oakland, CA 94612, USA, formerly at Dept. Earth Sciences & Ottawa Carleton Geoscience Center, Carleton University, Ottawa, Canada 2. Dept. Ea | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 5 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 6 | Development and evaluation of an efficient HPLC/MS/MS method for the simultaneous determination of pseudoephedrine and cetirzine in human plasma:Plasma:application to phase-1 pharmacolinetic study显示文摘 | Ma M Feng F Sheng Y | 2007 | Cromatogr B Analyt Technol Biomed Life Sci2007，846，12： | 1 |
| 7 | Metastasis and AKT activation显示文摘 | QIAO M SHENG S J PARDEE A B | 2008 | Cell Cycle2008，7，： | 1 |
| 8 | High-energy electrons produced in subpicosecond laser-plasma interactions from subrelativistic laser intensities to relativistic intensities显示文摘 | Li Y T Zhang J Sheng Z M | 2004 | Phys Rev E2004，69，03： | 1 |
| 9 | Evidence of aerobic denitrification显示文摘 | Ding A Z Fu J M Sheng G Y | 2000 | Chin Scie Bull2000，45，3： | 1 |
| 10 | Evidence of aerobicdenitrification 显示文摘 | Ding A Z Fu M Sheng G Y | 2000 | Chin Scie Bull2000，45，3： | 1 |
| 11 | Improved catalytic activi-ty and stability of mesostructured sulfated zirconia by Al promoter显示文摘 | YIN Y S LINA Y SHENG Q M | 2004 | Applied Catalysis A: General2004，268，15： | 1 |
| 12 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 13 | US Winter Migrants' Park Community Attributes: An Importance Performance Analysis 显示文摘 | Sheng X Simpson P M Siguaw J A | 2014 | Tourism Management2014，，43： | 1 |
| 14 | Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes显示文摘BACKGROUND Cigarette smoking(CS)is the most common method of consuming tobacco.Deleterious effects on bone integrity,increased incidence of fractures,and delayed fracture healing are all associated with CS.Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and,via the bloodstream,reach the skeletal system.New technologies designed to develop a reduced-risk alternative for smokers are based on electronic nicotine delivery systems,such as e-cigarettes and tobacco heating systems(THS).THS are designed to heat tobacco instead of burning it,thereby reducing the levels of harmful toxic compounds released.AIM To examine the effects of THS on osteoprogenitor cell viability and function compared to conventional CS.METHODS Human immortalized mesenchymal stem cells(n=3)and primary human preosteoblasts isolated from cancellous bone samples from BG Unfall Klinik Tübingen(n=5)were osteogenically differentiated in vitro with aqueous extracts generated from either the THS 2.4“IQOS”or conventional“Marlboro”cigarettes for up to 21 d.Cell viability was analyzed using resazurin conversion assay(mitochondrial activity)and calcein-AM staining(esterase activity).Osteogenic differentiation and bone cell function were evaluated using alkaline phosphatase(AP)activity,while matrix formation was analyzed through alizarin red staining.Primary cilia structure was examined by acetylatedα-tubulin immunofluorescent staining.Free radical production was evaluated with 2’,7’-dichlorofluoresceindiacetate assay.RESULTS Our data clearly show that THS is significantly less toxic to bone cells than CS when analyzed by mitochondrial and esterase activity(P<0.001).No significant differences in cytotoxicity between the diverse flavors of THS were observed.Harmful effects from THS on bone cell function were observed only at very high,non-physiological concentrations.In contrast,extracts from conventional cigarettes significantly reduced the AP activity(by two-fold)and matrix mineralization(four-fold)at low concentrations.Additionally,morphologic analysis of primary cilia revealed no significant changes in the length of the organelle involved in osteogenesis of osteoprogenitor cells,nor in the number of ciliated cells following THS treatment.Assessment of free radical production demonstrated that THS induced significantly less oxidative stress than conventional CS in osteoprogenitor cells.CONCLUSIONTHS was significantly less harmful to osteoprogenitor cells during osteogenesisthan conventional CS. Additional studies are required to confirm whether THS isa better alternative for smokers to improve delays in bone healing followingfracture. | Romina H Aspera-Werz Sabrina Ehnert Monja Müller Sheng Zhu Tao Chen Weidong Weng Johann Jacoby Andreas K Nussler | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 15 | Modeling Micro-inclusion Growth and Separation in Gas-Stirred Ladles 显示文摘 | SHENG Dong-yuan Soder M Jonsson P | 2002 | Scand J Metall2002，31，2： | 1 |
| 16 | The first year fol-low-up after colorectal adenoma polypectomy is impor-tant:A multiple-center study in symptomatic hospital-based individuals in Chian显示文摘 | Gao Q Y Chen H M Sheng J Q | 2010 | Front Med China2010，4，4： | 1 |
| 17 | Increased cadmium and lead uptake of a cadmium hyperaccumulator tomato by cadmium-resistant bacteria 显示文摘 | HE L Y CHEN A J REN G D ZHANG Y F QIAN M SHENG X F | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 18 | Feature-based process planning for environmentally conscious machining-part 1: micrnplanning 显示文摘 | Srinivasan M Sheng P | 1999 | Robotics and Computer-lntegrated Manufacturing1999，15，： | 1 |
| 19 | Ground vibration generated by a load moving along a railway track显示文摘 | Sheng X Jones C J C Petyt M | | 0，，： | 1 |
| 20 | Molecular evolution and functional specialization of chalcone synthase superfamily from Phalaenopsis orchid显示文摘 | Han Y Y Ming F Wang W Wang J W Ye M M Sheng D L | 2006 | Genetica2006，128，123： | 1 |
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