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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein 13 Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis显示文摘 | Hongli Lian Pengbo Xu Shengbo He Jun Wu Jian Pan Wenxiu Wang Feng Xu Sheng Wang Junsong Pan Jirong Huang Hong-Quan Yang | 2018 | Molecular Plant2018，11，10： | 10 |
| 3 | Inhibition of porcine circovirus type 1 and type 2 production in PK-15 cells by small interfering RNAs targeting the Rep gene显示文摘 | Minxuan Sun Xueqin Liu Shengbo Cao Qigai He Rui Zhou Jing Ye Yaoming Li Huanchun Chen | 2007 | Veterinary Microbiology2007，，1： | 1 |
| 4 | DNA methylation dynamics during germline development显示文摘DNA methylation plays essential homeostatic functions in eukaryotic genomes.In animals,DNA methylation is also developmentally regulated and,in turn,regulates development.In the past two decades,huge research effort has endorsed the understanding that DNA methylation plays a similar role in plant development,especially during sexual reproduction.The power of whole-genome sequencing and cell isolation techniques,as well as bioinformatics tools,have enabled recent studies to reveal dynamic changes in DNA methylation during germline development.Furthermore,the combination of these technological advances with genetics,developmental biology and cell biology tools has revealed functional methylation reprogramming events that control gene and transposon activities in flowering plant germlines.In this review,we discuss the major advances in our knowledge of DNA methylation dynamics during male and female germline development in flowering plants. | Shengbo He Xiaoqi Feng | 2022 | Journal of Integrative Plant Biology2022，64，12： | 1 |
| 5 | Bearing Fault Diagnosis with DDCNN Based on Intelligent Feature Fusion Strategy in Strong Noise显示文摘Intelligent fault diagnosis in modern mechanical equipment maintenance is increasingly adopting deep learning technology.However,conventional bearing fault diagnosis models often suffer from low accuracy and unstable performance in noisy environments due to their reliance on a single input data.Therefore,this paper proposes a dual-channel convolutional neural network(DDCNN)model that leverages dual data inputs.The DDCNN model introduces two key improvements.Firstly,one of the channels substitutes its convolution with a larger kernel,simplifying the structure while addressing the lack of global information and shallow features.Secondly,the feature layer combines data from different sensors based on their primary and secondary importance,extracting details through small kernel convolution for primary data and obtaining global information through large kernel convolution for secondary data.Extensive experiments conducted on two-bearing fault datasets demonstrate the superiority of the two-channel convolution model,exhibiting high accuracy and robustness even in strong noise environments.Notably,it achieved an impressive 98.84%accuracy at a Signal to Noise Ratio(SNR)of−4 dB,outperforming other advanced convolutional models. | Chaoqian He Runfang Hao Kun Yang Zhongyun Yuan Shengbo Sang Xiaorui Wang | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 6 | NUMERICAL APPROACH TO DETERMINING INSTANTANEOUS CONTACT REGION FOR CONJUGATE SURFACES显示文摘According to the defect of traditional method of determining instantaneous contact regions for conjugate surfaces, a numerical approach to the determination is proposed. A local coordinate system is built by using the surface unit tangent and unit normal at the contact point. Considering that the gap forming the boundary of instantaneous contact region in the direction of the common normal vectors is given, a system of nonlinear equations is built to fred the instantaneous contact boundary in local coordinate system, a modified Powell's hybrid algorithm of finite-difference approximation to the Jacobian used to solve the system. The new method simplifies the task of determining instantaneous contact regions without calculating curvature and relative curvature. The validity of the proposed approach is verified by an example of hypoid gears. | WANG Taiyong LI Jingcai HE Gaiyun FAN Shengbo HAO Yongjiang | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 0 |
| 7 | Chromatin conformation of human oral epithelium can identify orofacial cleft missing functional variants显示文摘Genome-wide association studies(GWASs) are the most widely used method to identify genetic risk loci associated with orofacial clefts(OFC). However, despite the increasing size of cohort, GWASs are still insufficient to detect all the heritability,suggesting there are more associations under the current stringent statistical threshold. In this study, we obtained an integrated epigenomic dataset based on the chromatin conformation of a human oral epithelial cell line(HIOEC) using RNA-seq, ATAC-seq,H3K27ac Ch IP-seq, and DLO Hi-C. Presumably, this epigenomic dataset could reveal the missing functional variants located in the oral epithelial cell active enhancers/promoters along with their risk target genes, despite relatively less-stringent statistical association with OFC. Taken a non-syndromic cleft palate only(NSCPO) GWAS data of the Chinese Han population as an example, 3664 SNPs that cannot reach the strict significance threshold were subjected to this functional identification pipeline.In total, 254 potential risk SNPs residing in active cis-regulatory elements interacting with 1 718 promoters of oral epitheliumexpressed genes were screened. Gapped k-mer machine learning based on enhancers interacting with epithelium-expressed genes along with in vivo and in vitro reporter assays were employed as functional validation. Among all the potential SNPs, we chose and confirmed that the risk alleles of rs560789 and rs174570 reduced the epithelial-specific enhancer activity by preventing the binding of transcription factors related to epithelial development. In summary, we established chromatin conformation datasets of human oral epithelial cells and provided a framework for testing and understanding how regulatory variants impart risk for clefts. | Yao Xiao Shengbo Jiao Miao He Da Lin Huanyan Zuo Jiahao Han Yonghua Sun Gang Cao Zhi Chen Huan Liu | 2022 | International Journal of Oral Science2022，14，4： | 0 |
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