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| 1 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 2 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 3 | Characterization of the putative tryptophan synthase β-subunit from Mycobacterium tuberculosis显示文摘药抵抗的肺结核(TB ) 的增加的出现形成严肃的威胁到这疾病的控制。开发新 TB 药在迫切需要。色氨酸 biosynthetic 小径在 Mycobacterium 肺结核(Mtb ) 的生长和复制起一个重要作用。色氨酸 synthase (TrpB ) 的子单元催化色氨酸 biosynthetic 的最后步小径,和它可能是为 TB 的一个潜在的目标药设计。在这研究,我们 overexpressed,净化,并且在 Mtb H37Rv 描绘了通常认为的编码 TrpB 基因 Rv1612。结果证明那项 Mtb His-TrpB 最佳的酶的活动在 pH 7.8 与在 37 的 0.15 M Na+ 或 0.18 M | Hongbo Shen Yanping Yang Feifei Wang Ying Zhang Naihao Ye Shengfeng Xu Honghai Wang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 1 |
| 4 | TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization显示文摘Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)cells.However,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in MS.Here,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse models.Conditional knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE mice.Furthermore,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE progression.In conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS. | Siying Qu Shengfeng Hu Huiting Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng Wang Xi Huang | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 5 | Dual-bionic regenerative microenvironment for peripheral nerve repair显示文摘Autologous nerve grafting serves is considered the gold standard treatment for peripheral nerve defects;however,limited availability and donor area destruction restrict its widespread clinical application.Although the performance of allogeneic decellularized nerve implants has been explored,challenges such as insufficient human donors have been a major drawback to its clinical use.Tissue-engineered neural regeneration materials have been developed over the years,and researchers have explored strategies to mimic the peripheral neural microenvironment during the design of nerve catheter grafts,namely the extracellular matrix(ECM),which includes mechanical,physical,and biochemical signals that support nerve regeneration.In this study,polycaprolactone/silk fibroin(PCL/SF)-aligned electrospun material was modified with ECM derived from human umbilical cord mesenchymal stem cells(hUMSCs),and a dual-bionic nerve regeneration material was successfully fabricated.The results indicated that the developed biomimetic material had excellent biological properties,providing sufficient anchorage for Schwann cells and subsequent axon regeneration and angiogenesis processes.Moreover,the dual-bionic material exerted a similar effect to that of autologous nerve transplantation in bridging peripheral nerve defects in rats.In conclusion,this study provides a new concept for designing neural regeneration materials,and the prepared dual-bionic repair materials have excellent auxiliary regenerative ability and further preclinical testing is warranted to evaluate its clinical application potential. | Yanjun Guan Zhiqi Ren Boyao Yang Wenjing Xu Wenjun Wu Xiangling Li Tieyuan Zhang Dongdong Li Shengfeng Chen Jun Bai Xiangyu Song Zhibo Jia Xing Xiong Songlin He Chaochao Li Fanqi Meng Tong Wu Jian Zhang Xiuzhi Liu Haoye Meng Jiang Peng Yu Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 6 | Study on oxygen transport and titanium oxidation in coating cracks under parallel gas flow based on LBM modelling显示文摘The oxygen transportation from surrounding air to coating cracks is an important factor in the oxidation and ignition of titanium alloy. In this work, the oxygen transport and surface oxidation of titanium in inclined cracks of coating under parallel airflow are studied with the lattice Boltzmann method(LBM).A boundary scheme of LBM about surface reaction is developed. The conversion factors are utilized to build the relationship between the physical scale and the lattice scale. The reliability of the LBM model is validated by the finite element method(FEM). The results show that the convective mass transport driven by the surrounding airflow and the vortex structure formed inside the crack are the two significant factors that influence the oxygen transport in cracks. The convective mass transfer plays a major role in oxygen transport when the inclination angle of the crack is small. For the cases with a large inclination angle, the oxygen transfer from the top to the bottom of the crack is mainly controlled by mass diffusion mechanism. The oxygen concentration in inclined cracks is generally less than that in vertical cracks, and oxidation and ignition of the substrate titanium might be more likely to occur in relatively vertical cracks. | Shengfeng Luo Song Zhang Yiping Zeng Hui Zhang Lili Zheng Zhaopeng Xu | 2023 | Chinese Journal of Chemical Engineering2023，56，4： | 0 |
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