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| 1 | Incidence and prevalence of moyamoya disease in urban China: a nationwide retrospective cohort study显示文摘Background and objective Moyamoya disease(MMD)is an increasingly recognised cause of stroke,mainly described in East Asia.China is the largest nation in Asia,but few studies reported the epidemiology of MMD,especially at a national level.We aimed to estimate the incidence and prevalence of MMD in China.Methods We performed a population-based study using data from the national databases of Urban Basic Medical Insurance between 2013 and 2016,covering approximately 0.50 billion individuals.MMD cases were identified by diagnostic code(International Classification of Diseases,10th Revision I67.5)or related diagnostic text.Results A total of 1987 MMD patients(mean age 44.45±14.30 years,female-to male ratio 1.12)were identified,representing a national crude incidence of 0.59(95%CI:0.49 to 0.68)and a prevalence of 1.01(95%CI:0.81 to 1.21)per 100000 person-years in 2016.Rates were higher in females than in males for the incidence(0.66 vs 0.52)and prevalence(1.05 vs 0.90).And the age-specific rates showed a bimodal distribution,with the highest peak in middle-aged group and the second peak in child group.Conclusions Our results confirm that MMD is relatively common in East Asians,but the rates in China were lower than those in other East Asian countries such as Japan and Korea.The unique epidemiological features,including a relatively weak female predominance and a shift in the highest peak of incidence from children to adults,revealed new sight into MMD.Further research is expected to explore the potential pathogenesis of MMD. | Yixin Sun Guoyu Zhou Jingnan Feng Lu Chen Guozhen Liu Jinxi Wang Qingliang Wang Junyou Yu Xiwang Yang Zheng Yang Pei Gao Shengfeng Wang Siyan Zhan | 2021 | Stroke & Vascular Neurology2021，6，4： | 4 |
| 2 | Effects of “Bioactive” amino acids leucine, glutamate, arginine and tryptophan on feed intake and mRNA expression of relative neuropeptides in broiler chicks显示文摘Feed intake control is vital to ensuring optimal nutrition and achieving full potential for growth and development in poultry. The aim of the present study was to investigate the effects of L-leucine, L-glutamate, L-tryptophan and L-arginine on feed intake and the mRNA expression levels of hypothalamic Neuropeptide involved in feed intake regulation in broiler chicks. Leucine, glutamate, tryptophan or arginine was intra-cerebroventricularly (ICV) administrated to 4d-old broiler chicks respectively and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of Neuropeptide Y (NPY), agouti related protein (AgRP), pro-opiomelanocortin (POMC), melanocortin receptor 4 (MC4R) and corticotrophin releasing factor (CRF). Our results showed that ICV administration of L-leucine (0.15 or 1.5 μmol) significantly (P<0.05) increased feed intake up to 2 h post-administration period and elevated both hypothalamic NPY and AgRP mRNA expression levels. In contrast, ICV administration of L-glutamate (1.6μmol) significantly (P<0.05) decreased feed intake 0.25, 0.5 and 2 h post-injection, and increased hypothalamic CRF and MC4R mRNA expression levels. Meanwhile, both L-tryptophan (10 or 100μg) and L-arginine (20 or 200μg) had no significant effect on feed intake. These findings suggested that L-leucine and L-glutamate could act within the hypothalamus to influence food intake, and that both orexigenic and anorexigenic Neuropeptide genes might contribute directly to these effects. | Songbo Wang Paul Khondowe Shengfeng Chen Jianjian Yu Gang Shu Xiaotong Zhu Lina Wang Ping Gao Qianyun Xi Yongliang Zhang Qingyan Jiang | 2012 | Journal of Animal Science and Biotechnology2012，3，4： | 3 |
| 3 | Selective laser melting of bulk immiscible alloy with enhanced strength:Heterogeneous microstructure and deformation mechanisms显示文摘To overcome the dimension limits of immiscible alloys produced by traditional techniques and enhance their mechanical properties,bulk Cu-Fe-based immiscible alloy with abundant nanotwins and stacking faults was successfully produced by selective laser melting(SLM).The SLM-produced bulk immiscible alloy displays a heterogeneous microstructure characterized by micro-scaledγ-Fe particles dispersed in fineε-Cu matrix with a high fraction(~92%)of high-angle grain boundaries.Interestingly,abundant nanotwins and stacking faults are generated in the interior of nano-scaledγ-Fe particles embedded withinε-Cu matrix.The heterogeneous interface of soft domains(ε-Cu)and hard domains(γ-Fe)not only induces the geometrically necessary dislocations(GNDs)but also affects the dislocation propagation during plastic deformation.Therefore,the bimodal heterogeneous interface,and the resistance of nanotwins and stacking faults to the propagation of partial dislocation make the bulk immiscible alloy exhibit an enhanced strength of~590 MPa and a good ductility of~8.9%. | Shengfeng Zhou Min Xie Changyi Wu Yanliang Yi Dongchu Chen Lai-Chang Zhang | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 4 | Recovery of Astaxanthin from Discharged Wastewater During the Production of Chitin显示文摘In this paper, studies were carried out to extract astaxanthin from discharged wastewater during the production of chitin and to reveal the scavenging effect of the obtained pigment on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. Different ratios of dichloromethane/methanol (V/V) were used to extract astaxanthin. When the ratio of dichloromethane/methanol was 2:8 and the ratio between the mixed organic solvent (dichloromethane/methanol, 2:8, V/V) and wastewater was 1:1, the highest yield of pigment was obtained (8.4 mg/ 50 mL). The concentration of free astaxanthin in the obtained pigment analyzed by HPLC was 30.02%. The obtained pigment possessed strong scavenging ability on DPPH radical and IC50 was 0.84mg/ml. | CHEN Xiaolin YANG Shengfeng XING Ronge YU Huahua LIU Song LI Pengcheng | 2012 | Journal of Ocean University of China2012，11，2： | 1 |
| 5 | Comprative study of optimization techniques for irrigation project planning显示文摘 | Kuo Shengfeng Liu Chenwuing Chen Shihkai | 2003 | Journal of the American Water Resources Association2003，39，1： | 1 |
| 6 | Feature selec- tion for text classification with Na'fve Bayes 显示文摘 | Jingnian Chen Houkuan Huang Shengfeng Tian | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 7 | Feature selection for text classification with Na lve Bayes显示文摘 | Jingnian Chen Houkuan Huang Shengfeng Tian Youli Qu | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 8 | 活性RAG转座子的发现揭示V(D)J重排的起源显示文摘有颌类脊椎动物适应性免疫起源的关键事件之一是介导抗体基因V(D)J重排机制的RAG1和RAG2蛋白的出现。有科学家认为RAG1/2源自一个古老的转座元件,但在此之前一直没有确切的证据证明这一点。 | Shengfeng Huang Xin Tao Shaochun Yuan Yuhang Zhang Peiyi Li Helen A.Beilinson Ya Zhang Wenjuan Yu Pierre Pontarotti Hector Escriva Yann Le Petillon Xiaolong Liu Shangwu Chen David G.Schatz 徐安龙 | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ显示文摘The balance between inflammatory T helper type 17(Th17)and immunosuppressive regulatory T(Treg)cells is critical for maintaining immune homeostasis in the human body and is tightly regulated under healthy conditions.An increasing number of studies have reported that deubiquitinases(DUBs)play a vital role in regulating Th17-and Treg-cell differentiation.However,the biological functions of only a small fraction of DUBs in Th17-and Treg-cell differentiation are well defined.In this study,we identified ubiquitin-specific peptidase 1(USP1)as a vital regulator of CD4+T-cell differentiation.USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation,thereby promoting the development of inflammatory diseases.Mechanistically,USP1 in CD4+T cells enhanced the activity of RORγt but promoted the proteasomal degradation of Foxp3 through deubiquitination and stabilization of TAZ in vitro and in vivo.Notably,ML323,a specific inhibitor of the USP1/UAF1 deubiquitinase complex,inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo,indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells.Our study highlights the critical role of USP1 in regulating adaptive immune responses and suggests that USP1 might be a drug target for the treatment of diseases associated with an imbalance between Th17 and Treg cells. | Xiaotong Zhu Peng Wang Xiaoxia Zhan Yuping Zhang Junli Sheng Shitong He Yitian Chen Dingnai Nie Xiaolong You Haiyan Mai Qinghong Yu Laisheng Li Ligang Jie Shengfeng Hu | 2023 | Cellular & Molecular Immunology2023，20，3： | 0 |
| 10 | Localization technique research of a pipeline robot based on the magnetic-dipole model显示文摘The magnetic field distribution of an emission antenna is studied in this paper.When the slenderness ratio of the emission antenna is high,the emission antenna can be simplified as a magnetic dipole for practical application.The numerical results of the magnetic dipole magnetic field show that the magnetic magnitude distribution has a hump-shape,whose direction is perpendicular with the antenna axis direction.A localization method based on the hump-shape signal detection is presented.The experimental result shows that the precision can reach a value of±5 cm.The method can be used to localize a pipeline robot working in a metal pipe. | Junyuan LI Hongjun CHEN Shengfeng LI Xiaohua ZHANG | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，1： | 0 |
| 11 | Diurnal Variation of Photosynthetic Physiological Characteristics of Kadsura coccinea(Lem.)A.C.Smith显示文摘[Objectives]This study was conducted to investigate the diurnal variations of photosynthetic and physiological characteristics in 3-year-old Kadsura coccinea(Lem.)A.C.Smith plants.[Methods]A Li-6400 portable photosynthetic system was used to study the diurnal variations of the photosynthetic physiological characteristics of K.coccinea.[Results]The diurnal variation of the net photosynthetic rate(Pn)of K.coccinea leaves showed a'double peak'curve,and there was a lunch break at noon.The maximum value of Pn[4.51 mmol/(m^(2)·s)]appeared at 10:00,and the daily average Pn was 3.98 mol/(m^(2)·s);and the stepwise regression analysis showed that photosynthetically active radiation(PAR)and stomatal conductance(Gs)were the main factors affecting Pn.The partial correlation analysis and path analysis showed that the order of effects on Pn was Gs>PAR.[Conclusions]This study provides a reference for further research on the development and utilization of K.coccinea. | Zongyou CHEN Shengfeng CHAI Xiaoxue QI Yujing Wei Huafei CEN | 2021 | Agricultural Biotechnology2021，10，4： | 0 |
| 12 | Exploring link generation in a temporal evolution network for human mobility显示文摘The prevalence of mobile devices has spurred human mobility to be applied in mobile networking and communications by using network science, in which the temporal evolution of a network topology is of great importance for protocol design and performance analysis. This paper focuses on link generation in a temporal evolution network. Based on observations revealing the strong correlation between the connection patterns of different time periods, a link generation potential based on historical connections is proposed in this paper, aiming to provide a method for making topological predictions with less randomness. Using MIT Reality dataset, an evaluation of the accuracy of the proposed method was conducted. The experimental results demonstrate the proposal's adequacy in terms of its accuracy. | SHI Yan SUN WangDong CHEN Bin ZHOU XiaoJuan CHEN ShanZhi WANG ShengFeng | 2016 | Science China(Technological Sciences)2016，59，1： | 0 |
| 13 | Dual-bionic regenerative microenvironment for peripheral nerve repair显示文摘Autologous nerve grafting serves is considered the gold standard treatment for peripheral nerve defects;however,limited availability and donor area destruction restrict its widespread clinical application.Although the performance of allogeneic decellularized nerve implants has been explored,challenges such as insufficient human donors have been a major drawback to its clinical use.Tissue-engineered neural regeneration materials have been developed over the years,and researchers have explored strategies to mimic the peripheral neural microenvironment during the design of nerve catheter grafts,namely the extracellular matrix(ECM),which includes mechanical,physical,and biochemical signals that support nerve regeneration.In this study,polycaprolactone/silk fibroin(PCL/SF)-aligned electrospun material was modified with ECM derived from human umbilical cord mesenchymal stem cells(hUMSCs),and a dual-bionic nerve regeneration material was successfully fabricated.The results indicated that the developed biomimetic material had excellent biological properties,providing sufficient anchorage for Schwann cells and subsequent axon regeneration and angiogenesis processes.Moreover,the dual-bionic material exerted a similar effect to that of autologous nerve transplantation in bridging peripheral nerve defects in rats.In conclusion,this study provides a new concept for designing neural regeneration materials,and the prepared dual-bionic repair materials have excellent auxiliary regenerative ability and further preclinical testing is warranted to evaluate its clinical application potential. | Yanjun Guan Zhiqi Ren Boyao Yang Wenjing Xu Wenjun Wu Xiangling Li Tieyuan Zhang Dongdong Li Shengfeng Chen Jun Bai Xiangyu Song Zhibo Jia Xing Xiong Songlin He Chaochao Li Fanqi Meng Tong Wu Jian Zhang Xiuzhi Liu Haoye Meng Jiang Peng Yu Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 14 | Effect of Down-regulated Expression of cPouV and cNanog on Pluripotency of Chicken(Gallus gallus) Embryonic Stem Cells(cESCs)显示文摘To explore the pluripotency maintenance and update the functional influence of pluripotency genes c Nanog and c Pou V in chicken( Gallus gallus) embryonic stem cells( c ESCs),the stable RNAi vectors p Super-c Nanog and p Super-c Pou V constructed previously were used to transfect c ESCs. The mRNA levels of two target genes were detected with real-time PCR. These two genes were down-regulated since the 48 thh and the down-regulation continued with the extension of time,the interference efficiency reached 65% at 96thhour( P < 0. 05). With the down-regulation of c Nanog or c Pou V gene,c ESCs showed differentiation and proliferation rate of these cells slowed down,the domed colony of these cells disappeared gradually when the edge of colony became irregular. At 96 thhour after transfection,the alkline phosphatase( AKP) and stage-specific embryonic antigen-1( SSEA-1) were not be detected in c Nanog gene-knocked out c ESCs,but it was done in that with c Pou V gene-knocked out. The c Pou V-suppressing c ESCs were again transfected with p Super-c Nanog,the pluripotency markers AKP and SSEA-1 were both not found expressing at the 48 thhour. The results showed that c Pou V and c Nanog genes played an important role in maintaining pluripotency and self- renewal in c ESCs,and c Nanog gene was dominant. To sum up,our results may provide insights into the molecular regulation mechanism of avian during development. | Zhisheng CHEN Te PENG Shengfeng CHEN Dongsheng LI Huiqin JI Bingyun WANG Jinding CHEN | 2015 | Agricultural Biotechnology2015，4，3： | 0 |
| 15 | Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway显示文摘Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum. | Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu | 2024 | Genes & Diseases2024，11，3： | 0 |
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