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| 1 | Multi-functional polyethersulfone nanofibrous membranes with ultra-high adsorption capacity and ultra-fast removal rates for dyes and bacteria显示文摘The adsorption technology has been widely applied in water remediation for contamination removal of dyes and bacteria,by virtue of the advantages of adsorption technology including high efficiency,energy conservation and ease of operation.Simultaneous removal of dyes and bacteria has been realized by some reported materials,but to achieve satisfactory adsorption amounts and rates remain an unmet goal for decades.Herein,a poly(methacrylatoethyl trimethyl ammonium chloride-co-methyl methacrylate)copolymer was synthesized,and then blended with polyethersulfone for the fabrication of nanofibrous membranes via electrospinning for the use of fast and massive removal of dyes and bacteria.Owing to the introduction of abundant quaternary ammonium groups,the maximum adsorption amount for methyl orange was up to 909.8 mg g^(-1).In addition,the modified nanofibrous membranes showed good recyclability,broad applications in severe environments,selective adsorption ability,and excellent dynamic removal performance.Especially,thanks to the abundant functional groups,the membranes showed fast adsorption ability for bacteria through electrostatic interaction.It should be noted that the clearance ratio for Staphylococcus aureus or Escherichia coli by 6 min of static adsorption could reach 93%or 90%for each.Additionally,dynamic removal ratio via filtration with the nanofibrous membranes could reach 99.7%for Staphylococcus aureus or 98.7%for Escherichia coli in 90 s.Therefore,the proposed approach towards the quaternary ammonium modified polyethersulfone nanofibrous membranes creates a new route for ultra-high adsorption capacity and ultra-fast removal rates for dyes and bacteria in water remediation. | Jianxu Bao Hang Li Yuanting Xu Shengqiu Chen Zhoujun Wang Chunji Jiang Huilin Li Zhiwei Wei Shudong Sun Weifeng Zhao Changsheng Zhao | 2021 | Journal of Materials Science & Technology2021，，19： | 4 |
| 2 | Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing显示文摘The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools.However,the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in mammalian cells,which significantly limits their utility.Here,we have developed a method termed Improving Editing Activity by Synergistic Engineering(MIDAS).This method exerts a synergistic effect to improve mammalian genome-editing efficiency of a wide range of CRISPR-Cas systems by enhancing the interactions of Cas nuclease with the protospacer adjacent motif(PAM)and the single-stranded DNA(ssDNA)substrate in the catalytic pocket simultaneously.MIDAS robustly and significantly increased the gene-editing efficiency of Cas12i,Cas12b,and CasX in human cells.Notably,a Cas12i variant,Cas12iMax,exhibited robust activity with a very broad PAM range(NTNN,NNTN,NAAN,and NCAN)and higher efficiency than the current widely used Cas nucleases.A high-fidelity version of Cas12iMax(Cas12iHiFi)has been further engineered to minimize off-target effects.Our work provides an expandable and efficacious method for engineering Cas nucleases for robust mammalian genome editing. | Yangcan Chen Yanping Hu Xinge Wang Shengqiu Luo Ning Yang Yi Chen Zhikun Li Qi Zhou Wei Li | 2022 | The Innovation2022，3，4： | 3 |
| 3 | Reducing obesity and inflammation in mice with organically-derivatized polyoxovanadate clusters显示文摘Obesity,characterized by the dysregulation of energy balance in adipose tissue and other metabolic organs,is frequently accompanied by chronic low-grade inflammation.As long-acting insulin sensitizers,the organically-derivatized polyoxovanadates(POVs),can extend the dosing interval of antidiabetic drugs from hourly to almost daily.In this work,the protective activity of POVs is investigated by an eight-week in vivo experiment,in which a small amount of POVs was administrated orally to a mouse model of dietinduced obesity every day.The present study shows that administration of POVs significantly decreases the body weight of mice,reduces adipose tissue accumulation,and simultaneously reduces adipose tissue inflammation.In addition,the anti-obesogenic population of i NKT cells is protected potentially by POVs,which subsequently alleviates visceral adipose tissue inflammation in high-fat-diet(HFD)-fed mice against diet-induced obesity.By contrast,the change in body weight after POV treatment is the result of a substantial reduction in fat mass,with no obvious effects on lean body mass.These findings demonstrate that supplementary of POVs would be an effective way to combat obesity and metabolic disorders while lowering metabolic inflammation. | Kun Chen Guoyong Dai Shengqiu Liu Yongge Wei | 2023 | Chinese Chemical Letters2023，34，5： | 2 |
| 4 | Sugar-rich sweet sorghum is distinctively affected by wall polymer features for biomass digestibility and ethanol fermentation in bagasse显示文摘 | Meng Li Shengqiu Feng Leiming Wu Ying Li Chunfen Fan Rui Zhang Weihua Zou Yuanyuan Tu Hai-Chun Jing Shizhong Li Liangcai Peng | 2014 | Bioresource Technology2014，，： | 1 |
| 5 | An integrative analysis of four CESA isoforms specific for fiber cellulose production between Gossypium hirsutum and Gossypium barbadense显示文摘 | Ao Li Tao Xia Wen Xu Tingting Chen Xianliang Li Jian Fan Ruyi Wang Shengqiu Feng Yanting Wang Bingrui Wang Liangcai Peng | 2013 | Planta2013，，6： | 1 |
| 6 | Analysis of five rice 4-coumarate:coenzyme A ligase enzyme activity and stress response for potential roles in lignin and flavonoid biosynthesis in rice显示文摘 | Haiyan Sun Ying Li Shengqiu Feng Weihua Zou Kai Guo Chunfen Fan Shengli Si Liangcai Peng | 2012 | Biochemical and Biophysical Research Communications2012，，： | 1 |
| 7 | Correction to:Buckling of Multiple Intersecting Spherical Shells Under Uniform External Pressure显示文摘The title of the article“Buckling of Multiple Intersecting Spherical Shells Under Uniform External Pressure,”written by Zhang,J.,Li,S.,Cui,W.et al.,was spelled incorrectly.The original article has been corrected. | Jian Zhang Shengqiu Li Weicheng Cui Kai Xiang Fang Wang Wenxian Tang | 2021 | Journal of Marine Science and Application2021，20，3： | 0 |
| 8 | A telomere-to-telomere reference genome provides genetic insight into the pentacyclic triterpenoid biosynthesis in Chaenomeles speciosa显示文摘Chaenomeles speciosa(2n=34),a medicinal and edible plant in the Rosaceae,is commonly used in traditional Chinese medicine.To date,the lack of genomic sequence and genetic studies has impeded efforts to improve its medicinal value.Herein,we report the use of an integrative approach involving PacBio HiFi(third-generation)sequencing and Hi-C scaffolding to assemble a high-quality telomere-to-telomere genome of C.speciosa.The genome comprised 650.4 Mb with a contig N50 of 35.5 Mb.Of these,632.3 Mb were anchored to 17 pseudo-chromosomes,in which 12,4,and 1 pseudo-chromosomes were represented by a single contig,two contigs,and four contigs,respectively.Eleven pseudo-chromosomes had telomere repeats at both ends,and four had telomere repeats at a single end.Repetitive sequences accounted for 49.5%of the genome,while a total of 45515 protein-coding genes have been annotated.The genome size of C.speciosa was relatively similar to that of Malus domestica.Expanded or contracted gene families were identified and investigated for their association with different plant metabolisms or biological processes.In particular,functional annotation characterized gene families that were associated with the biosynthetic pathway of oleanolic and ursolic acids,two abundant pentacyclic triterpenoids in the fruits of C.speciosa.Taken together,this telomere-to-telomere and chromosome-level genome of C.speciosa not only provides a valuable resource to enhance understanding of the biosynthesis of medicinal compounds in tissues,but also promotes understanding of the evolution of the Rosaceae. | Shaofang He Duanyang Weng Yipeng Zhang Qiusheng Kong Keyue Wang Naliang Jing Fengfeng Li Yuebin Ge Hui Xiong Lei Wu De-Yu Xie Shengqiu Feng Xiaqing Yu Xuekui Wang Shaohua Shu Zhinan Mei | 2023 | Horticulture Research2023，10，10： | 0 |
| 9 | The effects of dark-broken by UV-B,UV-A,and blue light on fertility of PGMR Nongken 58s显示文摘PGMR(Photoperiod sensitive Genic Male-sterile Rice) Nongken 58s was discovered in 1973 by SHI Mingsong, | YUE Bing LI Hesheng FENG Shengqiu Agro Dept.Huazhong Agri Univ,Wuhan 430070,China | 1998 | Chinese Rice Research Newsletter1998，6，2： | 0 |
| 10 | Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization显示文摘New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital importance.Although antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are scarce.Herein,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular layer.This synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal tissue.In infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo models.In other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound. | Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang Hirotaka Ejima Junling Guo Changsheng Zhao | 2022 | Bioactive Materials2022，7，10： | 0 |
| 11 | Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice显示文摘Obesity is closely related with insulin resistance and chronic inflammation.Here,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated inflammation.Oral administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat diet.ULPOV treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight control.In addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by obesity.These data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity. | Kun Chen Shengqiu Liu Yujun Wei | 2024 | Nano Research2024，17，3： | 0 |
| 12 | Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing显示文摘Dear editor.The remarkably diversified CRISPR-Cas systems in nature have provided unlimited valuable resources to develop genome editing tools that are revolutionizing the fields of biotechnology and medicine.However,due to their microbial origin,the activity of most naturally occurring CRISPR-Cas nucleases is relatively poor in mammalian cells(Ran et al.,2015).Thus,improving the mammalian genome editing efficiency becomes the priority for harnessing more CRISPRCas systems for widespread applications.Rational protein engineering serves as a powerful approach to enhance the catalytic activity of enzymes.Whereas,this approach largely relies on proteinic three-dimension(3D)structure information as guide for design.The fact is that of the large numbers of the CRISPR-Cas systems discovered in recent years,only a small number of them with the 3D structures were reported.To bypass this limitation,here,we report an efficient and simple strategy for rational engineering of Cas nucleases without the need of 3D structure information and successfully optimized nucleases from Cas9 and Cas12 families. | Yangcan Chen Yanping Hu Shengqiu Luo Xinge Wang Bangwei Mao Yi Chen Jing Xu Zhikun Li Qi Zhou Wei Li | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 13 | 受均匀外压作用的多个贯穿球壳屈曲研究显示文摘This study explored the buckling of multiple intersecting spherical shells.A three-segment spherical shell was designed using the theory of deformation coordination;the design was compared with that of a volume-equivalent cylindrical shell and ring-ribbed cylindrical shell.The numerical results indicated that the buckling capacity of the three-segment spherical shell was superior to those of the other two cylindrical shells.To validate our numerical approach,three laboratory-scale shell models were fabricated.Each model was accurately measured and slowly tested in a pressure chamber;thus,the tested shells were studied numerically.The experimental collapse modes agreed well with numerical results,and the collapse load of the three-segment pressure shell was considerably higher than that of the two cylindrical shells. | Jian Zhang Shengqiu Li Weicheng Cui Kai Xiang Fang Wang Wenxian Tang | 2020 | Journal of Marine Science and Application2020，19，4： | 0 |
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