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| 1 | Generation of pancreatic islet cells from human embryonic stem cells显示文摘Efficiently obtaining functional pancreatic islet cells derived from human embryonic stem(hES) cells not only provides great potential to solve the shortage of islets sources for type I diabetes cell therapy,but also benefits the study of the development of the human pancreas and diabetes pathology.In 2001,hES cells were reported to have the capacity to generate insulin-producing cells by spontaneous differentiation in vitro.Since then,many strategies(such as overexpression of key transcription factors,delivery of key proteins for pancreatic development,co-transplantation of differentiated hES cells along with fetal pancreas,stepwise differentiation by mimicking in vivo pancreatic development) have been employed in order to induce the differentiation of pancreatic islet cells from hES cells.Moreover,patient-specific induced pluripotent stem(iPS) cells can be generated by reprogramming somatic cells.iPS cells have characteristics similar to those of ES cells and offer a new cell source for type I diabetes cell therapy that reduces the risk of immunologic rejection.In this review,we summarize the recent progress made in the differentiation of hES and iPS cells into functional pancreatic islet cells and discuss the challenges for their future study. | ZHANG DongHui1,2,JIANG Wei1,SHI Yan2 & DENG HongKui1,2 1 Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education,College of Life Sciences,Peking University,Beijing 100871,China 2 Laboratory of Chemical Genomics,Shenzhen Graduate School of Peking University,Shenzhen 518055,China | 2009 | Science China(Life Sciences)2009，52，7： | 6 |
| 2 | Large-area hydrated vanadium oxide/carbon nanotube composite films for high-performance aqueous zinc-ion batteries显示文摘Synchronously reducing/self-assembling strategy on Zn substrate was designed to fabricate large-area cation-doped hydrated V_(2)O_(5)/multi-walled carbon nanotube(D-HVO/MWCNT)composite films.Interestingly,the Zn^(2+)ions are simultaneously doped in hydrated V_(2)O_(5) during the assembly process,which will be beneficial to the high electrochemical performance of hydrated V_(2)O_(5).By further combining 3D conductive MWCNT network,the freestanding D-HVO/MWCNT composite films display high capacity,excellent rate capability,and remarkable long-term cycling performance(up to 10,000 cycles with a high capacity retention of 98.5%).Moreover,owing to the high conductivity and flexibility of the D-HVO/MWCNT composite films,the softpackaged aqueous zinc-ion batteries(ZIBs)were constructed based on such composite films.The devices exhibit stable electrochemical performance even under different bending states.Therefore,such a strategy provides a promising route to achieve large-area carbon and metal oxides-based composite films with high performance and good flexibility. | Hongmei Cao Shenzhen Deng Zhiwei Tie Jinlei Tian Lili Liu Zhiqiang Niu | 2022 | Science China Chemistry2022，65，9： | 1 |
| 3 | Characteristics and Causes of the Spatial Evolution of Urban Villages:A Case Study of Shenzhen Special Economic Zone | TONG De,Shenzhen Graduate School of Peking University FENG Changchun,Professor,Director of Center of Urban and Economic Geography,College of Urban and Environmental Sciences,Peking University,Beijing,P.R.China. DENG Jinjie,Shenzhen Graduate School of Peking University,Shenzhen,P.R.China.SHI Ke | 2012 | China City Planning Review2012，21，3： | 0 |
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