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| 1 | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system显示文摘允许的技术内长的基因的特定的规定为基因功能的学习是珍贵的并且在治疗学有大潜力。我们创造了在 CRISPR 上系统,由核酸酶死者 Cas9 (dCas9 ) 蛋白质组成的二部件的 transcriptional 使活跃之物与互补顺序与 transcriptional 激活域和单个指南 RNA (sgRNAs ) 熔化了到基因倡导者。我们证明在 CRISPR 上能高效地以一种悦耳的方式在人和老鼠房间激活外长的记者基因。另外,我们证明在 vivo 的柔韧的记者基因激活能被把系统部件注入老鼠接合子完成。而且,我们证明在 CRISPR 上能激活内长的 IL1RN, SOX2,和 OCT4 基因。最有效的基因激活被对近似倡导者有约束力的 3-4 sgRNAs 的簇完成,建议他们在基因正式就职的 synergistic 行动。显著地,当指向多重基因的 sgRNAs 同时被介绍进房间时,柔韧的多路的内长的基因激活被完成。染色体宽的表示介绍表明了系统的高特性。 | Albert W Cheng Haoyi Wang Hui Yang Linyu Shi Yarden Katz Thorold W Theunissen Sudharshan Rangarajan Chikdu S Shivalila Daniel B Dadon Rudolf Jaenisch | 2013 | Cell Research2013，23，10： | 65 |
| 2 | Metal contamination in urban, suburban and country park soils of Hong Kong: A study based on GIS and multivariate statistics显示文摘 | Lee C S Li X Shi W | 2006 | The Science of the Total Environment2006，356，13： | 1 |
| 3 | Synthesis and microstructure of gallium phosphide nanowires 显示文摘 | Zheng Y F Wang N | 2001 | J Vac Sci Tech B2001，19，4： | 1 |
| 4 | Lipid nanoparticles loaded with 10hydroxyeamptothecinphospholipid complex developed for the treatment of hepatoma in clinical application显示文摘 | WEI W SHI S J LIU J | 2010 | J Drug Target2010，18，7： | 1 |
| 5 | Adsorption of Cu ( I1 ) and Pb ( 11 ) onto diethylenetriamine-bacterial cellulose 显示文摘 | Shen W Chen S Y Shi S K | 2009 | Carbohydrate Polymers2009，75，1： | 1 |
| 6 | Uniform deposition ofultrathin polymer films on the surfaces of Al2O3 nanoprticles by a plasma treatment 显示文摘 | Shi D L Wang S X Ooij W J V | 2001 | Appl Phys Lett2001，78，： | 1 |
| 7 | A novel role for defensins in intesti- nal homeostasis: regulation of IL-1beta secretion 显示文摘 | Shi J Aono S Lu W | 2007 | J Im- munol2007，179，： | 1 |
| 8 | Baicalin inhibits TLR2/4 signa- ling pathway in rat brain following permanent cerebral ischemia 显示文摘 | Tu X K Yang W Z Shi S S | 2011 | Inflammation2011，34，5： | 1 |
| 9 | Immuno protection against influenza virus H9N2 by the oral administration of recombinant Lactobacillus planta- rumNC8 expressing hemagglutinin in BALB/c mice 显示文摘 | SHI S H YANG W T YANG G L | 2014 | Virology2014，，： | 1 |
| 10 | Nonlocal Image Restoration with Bilateral Variance Estimation: a Low-rank Approach 显示文摘 | DONG W S SHI G M LI X | 2013 | IEEE Transactions on Image Processing2013，22，2： | 1 |
| 11 | Coal liquefaction technoln- gies--development in China and challenges in chemical reaction engineering显示文摘 | I IU Z Y SHI S D LI Y W | 2010 | Chemical Engineering Science2010，65，1： | 1 |
| 12 | Microstructures of Gallium Nitride Nanowires Synthesized by Oxide-Assisted Method显示文摘 | Shi W S Zhang Y F Wang N | 2001 | Chemical Physics Letters2001，345，： | 1 |
| 13 | Real-time visualization of high- intensity focused ultrasound imaging显示文摘 | Vaezy S Shi X Martin R W | 2001 | Uhrasound Med Biol2001，27，1： | 1 |
| 14 | Microstructure of gallium nitride nanowires synthesized by oxide-assisted method 显示文摘 | Zheng Y F Wang N | 2001 | Chem Phys Lett2001，345，： | 1 |
| 15 | Flame retardant mechanism of hyperbranched polyurethane acrylates used for UV curable flame retardant coatings显示文摘 | Zhu S W Shi W F | 2002 | Polymer Degradation and Stability2002，75，3： | 1 |
| 16 | Metal contamination in urban,suburban,and country park soils of Hong Kong:A study based on GIS and multivariate statistics显示文摘 | Lee C S Li X Shi W | 2006 | Science of the Total Environment2006，356，13： | 1 |
| 17 | Application of the stable-isotope system to the study of sources and fate of Hg in the en- vironment: A review显示文摘 | Yin R S Feng X B Shi W F | 2010 | Applied Geochemistry2010，25，10： | 1 |
| 18 | Comparative study of anion polyacrylamide (APAM) adsorption-related fouling o a PVDF UF membrane and a modified PVDF UF membrane 显示文摘 | YiXS Shi W X Yu S L Sun N Jin L M Wang S Zhang B Ma C Sun L P | 2012 | Desalination2012，286，： | 1 |
| 19 | Benefit and cost analysis of mariculture based on ecosystem services 显示文摘 | Zheng W Shi H Chen S | 2009 | Ecological Economics2009，68，6： | 1 |
| 20 | Defect gap solitons in selbfocusing Kerr media with paritFtime symmetric linear superlattices and modulated nonlinear lattices 显示文摘 | Wang H He W Shi S etal | 2014 | Physica Seripta2014，89，02： | 1 |
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