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| 1 | Pollen-inferred vegetation and environmental changes since 16.7 ka BP at Balikun Lake, Xinjiang显示文摘A high-resolution fossil pollen record from the sedimentary cores of Balikun Lake, northwestern China, combined with modern surface pollen data, is used to reconstruct the history of vegetation and climatic change since 16.7 cal. ka BP. Fossil pollen assem-blages and lithology indicate that the study area was dominated by desert. The desert had extremely arid climate and lower effec-tive moisture during 16.7–7.9 cal. ka BP, especially from 16.7 to 8.9 cal. ka BP when the lake maybe dried up. During 8.9–7.9 cal. ka BP, the environment gradually recovered in this area. It was then followed by the optimum period from 7.9 to 4.3 cal. Ka BP, when the effective moisture obviously increased. It was characterized by the typical desert-steppe/steppe vegetation and was ac-companied with several patch-birch woodlands around the lake. After that, a short but extremely arid climatic event occurred during 4.3–3.8 cal. ka BP, and the vegetation quickly changed from desert-steppe/steppe to desert. It was a relatively optimum period from 3.8 to 0.53 cal. ka BP showing typical desert-steppe/meadow-steppe landscape. Since 0.53 cal. ka BP, the climate has shown signs of deteriorating again. Furthermore, regional comparison shows that the characteristics of climatic and environmental evolution in this area were clearly different from East Asia monsoonal area during the last 16.7 cal. ka BP. It was characterized by the arid climate during the late-glacial and early Holocene, and relatively wet during the mid-late Holocene. | TAO ShiChen AN ChenBang CHEN FaHu TANG LingYu WANG ZongLi LU YanBin LI ZhiFei ZHENG TongMing ZHAO JiaJu | 2010 | Chinese Science Bulletin2010，55，22： | 20 |
| 2 | Recent advances and prospects toward blue perovskite materials and light-emitting diodes显示文摘Perovskite based light-emitting diodes(PeLEDs)have become a powerful candidate for next-generation solid-state lightings and high-definition displays due to their high photoluminescence quantum yield(PLQY),tunable emission wavelength over the visible spectrum,and narrow emission linewidths.Over the past few years,the development of red-and green-emissive PeLEDs has rapidly increased,and the corresponding external quantum efficiencies(EQE)have exceeded 20%.However,the research progress of blue-emitting PeLEDs is limited by its poor material quality and inappropriate device structure.Currently,the maximum EQE of blue PeLED is only 6.2%,which is far from the industrialization requirements.In order to promote the development of blue PeLEDs,we summarize the recent research progress of blue perovskite materials and LEDs and discuss several fatal challenges,mainly embodied in low efficiency and poor stability.In order to overcome these challenges,detailed analysis and strategies are put forward in terms of the materials and devices.For the former,we summarize the feasible strategy for the preparation of efficient and stable blue-emissive perovskites using component engineering.For the latter,we analyze the advantages and limitations of the different strategies for blue-emissive perovskite in LEDs.At the end of the review,a comprehensive outlook is detailed,including future development directions and several technical problems to be solved.Thus,we aim to highlight the significance and promote the industrialization of PeLEDs. | Tao Fang Fengjuan Zhang Shichen Yuan Haibo Zeng Jizhong Song | 2019 | InfoMat2019，1，2： | 9 |
| 3 | Influence of Aspect Ratio on Rolling Shear Properties of Fast-Grown Small Diameter Eucalyptus Lumber显示文摘Eucalyptus is a major fast-grown species in South China,which has the potential for producing structural wood products such as cross-laminated timber(CLT).Aspect ratio(board width vs.board thickness)of eucalyptus lumbers is small due to the small diameter of fast-grown eucalyptus wood.To evaluate its rolling shear modulus and strength for potential CLT applications,three-layer hybrid CLT shear block specimens with different aspect ratios(2,4,6),were tested by planar shear test method.Digital image correlation(DIC)was employed to measure the rolling shear strain distribution and development during the planar shear tests.The mean values of rolling shear modulus and strength of eucalyptus lamination were 260.3%and 88.2%higher than those of SPF(Spruce-pine-fir)lamination with the same aspect ratio of 4,respectively.The rolling shear properties of eucalyptus laminations increased as the aspect ratio increased.Aspect ratio had a significant influence on rolling shear modulus compared to rolling shear strength.The high shear strain regions were primarily found around the gaps between segments of cross layer.The quantity of high shear strain regions increased as the aspect ratio of lamination decreased.Other high shear strain regions also occurred around the pith and along the glue line.The sudden failure of specimen occurred in the high strain region.In conclusion,the rolling shear strength and modulus of fast-grown eucalyptus laminations exceed the respective characteristic values for softwoods in the current standard by roughly factors of 3 and 8,indicating great potential for fast-grown eucalyptus wood cross-layers in CLT. | Tao Gui Shichen Cai Zhiqiang Wang Jianhui Zhou | 2020 | Journal of Renewable Materials2020，8，9： | 2 |
| 4 | El Ni?o/Southern Oscillation during the 4.2 ka event recorded by growth rates of corals from the North South China Sea显示文摘The 4.2 ka event that occurred during the period from 4 500–3 900 a BP was characterized by cold and dry climates and resulted in the collapse of civilizations around the world. The cause of this climatic event, however, has been under debate. We collected four corals(Porites lutea) from Yongxing Island, Xisha Islands, South China Sea, dated them with the U-series method, and measured the annual coral growth rates using X-ray technology. The dating results showed that the coral growth ages were from 4 500–3 900 a BP, which coincide well with the period of the4.2 ka event. We then reconstructed annual sea surface temperature anomaly(SSTA) variations based on the coral growth rates. The growth rate-based SSTA results showed that the interdecadal SSTA from 4 500–3 900 a BP was lower than that during modern times(1961–2008 AD). A spectral analysis showed that the SSTA variations from4 500–3 900 a BP were under the influence of El Nino-Southern Oscillation(ENSO) activities. From 4 500–4 100 a BP, the climate exhibited La Nina-like conditions with weak ENSO intensity and relatively stable and lower SSTA amplitudes. From 4 100–3 900 a BP, the climate underwent a complicated period of ENSO variability and showed alternating El Nino-or La Nina-like conditions at interdecadal time scales and large SSTA amplitudes. We speculate that during the early and middle stages of the 4.2 ka event, the cold climate caused by weak ENSO activities largely weakened social productivity. Then, during the end stages of the 4.2 ka event, the repeated fluctuations in the ENSO intensity caused frequent extreme weather events, resulting in the collapse of civilizations worldwide. Thus, the new evidence obtained from our coral records suggests that the 4.2 ka event as well as the related collapse of civilizations were very likely driven by ENSO variability. | Shaohua Dang Kefu Yu Shichen Tao Tao Han Huiling Zhang Wei Jiang | 2020 | Acta Oceanologica Sinica2020，39，1： | 1 |
| 5 | Dust variation recorded by lacustrine sediments from arid Central Asia since ~<ce:hsp sp='0.10'/>15 cal ka BP and its implication for atmospheric circulation显示文摘 | Cheng-Bang An Jiaju Zhao Shichen Tao Yanbin Lv Weimiao Dong Hu Li Ming Jin Zongli Wang | 2010 | Quaternary Research2010，，3： | 1 |
| 6 | SHARPIN激活HOIP用于线性泛素链组装的结构透视显示文摘文章简介线性泛素链组装复合物LUBAC是目前唯一被发现的、催化线性泛素链合成的E3泛素连接酶复合物,它由HOIP,HOIL-1L和SHARPIN三个蛋白组成。 | Jianping Liu Yingli Wang Yukang Gong Tao Fu Shichen Hu Zixuan Zhou 潘李峰 | 2018 | 科学新闻2018，0，4： | 0 |
| 7 | New insights into developmental biology of Eimeria tenella revealed by comparative analysis of mRNA N6-methyladenosine modification between unsporulated oocysts and sporulated oocysts显示文摘Evidence showed that N6-methyladenosine(m^(6)A)modification plays a pivotal role in influencing RNA fate and is strongly associated with cell growth and developmental processes in many species.However,no information regarding m^(6)A modification in Eimeria tenella is currently available.In the present study,we surveyed the transcriptome-wide prevalence of m^(6)A in sporulated oocysts and unsporulated oocysts of E.tenella.Methylated RNA immunoprecipitation sequencing(MeRIP-seq)analysis showed that m^(6)A modification was most abundant in the coding sequences,followed by stop codon.There were 3,903 hypermethylated and 3,178 hypomethylated mRNAs in sporulated oocysts compared with unsporulated oocysts.Further joint analysis suggested that m^(6)A modification of the majority of genes was positively correlated with mRNA expression.The mRNA relative expression and m^(6)A level of the selected genes were confirmed by quantitative reverse transcription PCR(RT-qPCR)and MeRIP-qPCR.GO and KEGG analysis indicated that differentially m^(6)A methylated genes(DMMGs)with significant differences in mRNA expression were closely related to processes such as regulation of gene expression,epigenetic,microtubule,autophagy-other and TOR signaling.Moreover,a total of 96 DMMGs without significant differences in mRNA expression showed significant differences at protein level.GO and pathway enrichment analysis of the 96 genes showed that RNA methylation may be involved in cell biosynthesis and metabolism of E.tenella.We firstly present a map of RNA m^(6)A modification in E.tenella,which provides significant insights into developmental biology of E.tenella. | Qing Liu Bingjin Mu Yijing Meng Linmei Yu Zirui Wang Tao Jia Wenbin Zheng Wenwei Gao Shichen Xie Xingquan Zhu | 2024 | Journal of Integrative Agriculture2024，23，1： | 0 |
| 8 | A novel protein domain is important for photosystem Ⅱ complex assembly and photoautotrophic growth in angiosperms显示文摘Photosystem Ⅱ(PSⅡ)is a multi-subunit protein complex of the photosynthetic electron transport chain that is vital to photosynthesis.Although the structure,composition,and function of PSⅡ have been extensively studied,its biogenesis mechanism remains less understood.Thylakoid rhodanese-like(TROL)provides an anchor for leaf-type ferredoxin:NADP^(+)oxidoreductase.Here,we report the chacterizaton of a second type of TROL protein,TROL2,encoded by seed plant genomes whose function has not previously been reported.We show that TROL2 is a PSⅡ assembly cofactor with essential roles in the establishment of photoautotrophy.TROL2 contains a 45-amino-acid domain,termed the chlorotic lethal seedling(CLS)domain,that is both necessary and sufficient for TROL2 function in PSⅡ assembly and photoautotrophic growth.Phylogenetic analyses suggest that TROL2 may have arisen from ancestral TROL1 via gene duplication before the emergence of seed plants and acquired the CLS domain via evolution of the sequence encoding its N-terminal portion.We further reveal that TROL2(or CLS)forms an assembly cofactor complex with the intrinsic thylakoid membrane protein LOW PSⅡ ACCUMULATION2 and interacts with small PSⅡ subunits to facilitate PSⅡ complex assembly.Collectively,our study not only shows that TROL2(CLS)is essential for photoautotrophy in angiosperms but also reveals its mechanistic role in PSⅡ complex assembly,shedding light on the molecular and evolutionary mechanisms of photosynthetic complex assemblyin angiosperms. | Wei Li Jiangfan Guo Xue Han Xiaowen Da Kai Wang Hongfei Zhao Shi-Tang Huange Bosheng Li Hang He Ruirui Jiang Shichen Zhou Peng Yan Tao Chen Yi He Jiming Xu Yu Liu Yunrong Wu Huixia Shou Zhongchang Wu Chuanzao Mao Xiaorong Mo | 2023 | Molecular Plant2023，16，2： | 0 |
| 9 | Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin显示文摘Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML cells.Here,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive resistance.Mitochondrial metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of mTOR.Consequently,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of AML.Through a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA binding.Gardenoside synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft model.These results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML. | Zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou | 2024 | Genes & Diseases2024，11，1： | 0 |
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