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您的检索式：作者名="Shifang SHAO"
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| 1 | Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds显示文摘Wound infections are a compelling health issue caused by the invasion and proliferation of pathogens in wound sites.Antibioticloaded hydrogels are widely used to achieve anti-infectious wound healing.However,due to the quick emergence of drugresistant bacteria,such as methicillin-resistant Staphylococcus aureus(MRSA),wound infection has been a formidable challenge to human health.To address MRSA-infected wounds,an antibacterial peptide polymer-loaded hyaluronic acid(HA)hydrogel(Gel-HA@P)is prepared.The peptide polymer is designed to mimic host defense peptides as the antibiotic alternative showing potent antibacterial activity,low susceptibility to drug resistance and good stability against proteolysis.HA is biocompatible and biodegradable hydrogel substrate as a primary constituent of the extracellular matrix and suitable for cell migration and wound healing.Gel-HA@P shows potent activity against MRSA in vitro and in vivo,low toxicity during the treatment and promotes the wound healing in vivo.This design has proven to be an effective and antibiotic-free strategy to enable the healing of MRSA-infected wounds. | Zhongqian Qiao Wenjing Zhang Yueming Wu Weinan Jiang Ning Shao Jiayang Xie Guixue Xia Qimeng Chen Zhefeng Liu Jingcheng Zou Jiawei Gu Shifang Luan Haodong Lin Runhui Liu | 2023 | Science China Chemistry2023，66，6： | 1 |
| 2 | Population Ecology of Ilex cornuta in Longgan Lake National Nature Preserve,Hubei Province显示文摘The population size class structure,survival curve,height class structure and population distribution patterns of Ilex cornuta in Longgan Lake National Nature Preserve,Hubei Province,were investigated by using the adjacent grid method. The result showed that the population age structure of I. cornuta was of middle-aging type,in the vertical space of population individuals,most of them lived in the shrub layer,and a small number of individuals entered the arborous layer.The distribution pattern of I. cornuta was analyzed by variance/mean ratio method,and the results showed that the distribution pattern of the population was the cluster type. This study can provide references for the further protection,research and development and utilization of I. cornuta. | Junjie YANG Shifang SHAO Xiao GUO Yuanping FANG | 2018 | Agricultural Biotechnology2018，7，5： | 0 |
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