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| 1 | Recent Advances in Space-Deployable Structures in China显示文摘Deployable space structure technology is an approach used in building spacecraft,especially when realizing deployment and folding functions.Once in orbit,the structures are released from the fairing,deployed,and positioned.With the development of communication,remote-sensing,and navigation satellites,space-deployable structures have become cutting-edge research topics in space science and technology.This paper summarizes the current research status and development trend of spacedeployable structures in China,including large space mesh antennas,space solar arrays,and deployable structures and mechanisms for deep-space exploration.Critical technologies of space-deployable structures are addressed from the perspectives of deployable mechanisms,cable-membrane form-finding,dynamic analysis,reliable environmental adaptability analysis,and validation.Finally,future technology developments and trends are elucidated in the fields of mesh antennas,solar arrays,deployable mechanisms,and on-orbit adjustment,assembly,and construction. | Xiaofei Ma Tuanjie Li Jingya Ma Zhiyi Wang Chuang Shi Shikun Zheng Qifeng Cui Xiao Li Fan Liu Hongwei Guo Liwu Liu Zuowei Wang Yang Li | 2022 | Engineering2022，，10： | 6 |
| 2 | A micro-scale strain rosette for residual stress measurement by SEM Moiré method显示文摘In this paper,a new method combining focused ion beam(FIB)and scanning electron microscope(SEM)Moirétechnique for the measurement of residual stress at micro scale is proposed.The FIB is employed to introduce stress relief like the macro ring-core method and fabricate gratings with a frequency of 5000 lines/mm on the measured area of the sample surface.Three groups of gratings in different radial directions are manufactured in order to form a micro-scale strain rosette.After milling ring-core by FIB,the deformation incurred by relief of the stress will be recorded with the strain rosette.The displacement/strain field can be measured using SEM scanning Moiréwith random phase-shifting algorithm.In this study,the Nickel alloy GH4169 sample(which was processed by laser shock peening)is selected as a study object to determine its residual stress.The results showed that the components of the in-plane principal stresses were-359 MPa and-207 MPa,respectively,which show good agreement with the results obtained from the available literature. | ZHU RongHua XIE HuiMin ZHU JianGuo LI YanJie CHE ZhiGang ZOU ShiKun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 6 |
| 3 | Subthalamic nucleus deep brain stimulation for Parkinson’s disease: 8 years of follow-up显示文摘Objective:The short-term benefits of bilateral stimulation of the subthalamic nucleus(STN)in patients with advanced Parkinson’s disease(PD)are well documented,but long-term benefits are still uncertain.The aim of this study is to evaluate the outcome of 8 years of bilateral STN stimulation to PD patients.Methods:In this study,31 consecutive PD patients were treated with bilateral STN stimulation.Their functional status was measured using the Activities of Daily Living section of the Unified Parkinson’s Disease Rating Scale(UPDRS-ADL)at drug on(with medication)and drug off(without medication)states preoperatively and at 1,5,and 8 years postoperatively.In addition,Levodopa equivalent doses and stimulation parameters were also assessed.Results:After 8 years of STN stimulation,the UPDRS-ADL scores were improved by 4%at drug off status(P>0.05)and 22%at drug on status(P<0.05)compared with baseline;the levodopa daily doses were reduced by 28%(P<0.05)compared with baseline;the stimulation voltage and pulse width were not changed,but the stimulation frequency was decreased remarkably compared with the 5 years of follow-up.Adverse events were observed in 6 patients,including misplacement of the electrode and skin erosion requiring further surgery.All events were resolved without permanent sequelae.2 patients died of aspiration pneumonia 6 and 7 years after surgery.Conclusions:The marked improvement in UPDRS-ADL scores were still observed after 8 years of bilateral STN stimulation with medication. | Dianyou Li Chunyan Cao Jing Zhang Shikun Zhan Shengdi Chen Bomin Sun | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 4 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 5 | Synthesis and crystal structure of hydroquinone-β-cyclo-dextrin complex显示文摘The title inclusion complex with the formula [(C42H70O35)2 · (C6O2H6)3 · (H2O)21.2(CH3OH)2] has been crystallized and characterized by single crystal X-ray analysis. The complex crystallizes in the triclinic system, space group P1, with a =1.5500 (1), b =1.5536(1), c = 1.8246(1) nm, α = 113.17(2), β = 99.12(2), γ=103.37(3)? V = 3.7739(4) nm3, Z = 1; Dc =1.343 g/cm3, μ = 0.124 mm-1, F(000) = 1594, R = 0.0795 and S = 0.9639. Two independent molecules of β-cyclodextrin (β-CD) form a 'head-to-head' dimer. The fairly important factor of the position and stability of the guest in the host cavity is the solvation of the polar group of the guest. | Shikun Ma Jinling Wang Aixiu Li Ming Yu Ming Sun Xiumei Su Fangming Miao | 2001 | Chinese Science Bulletin2001，46，5： | 3 |
| 6 | Online measurement of alkalinity in anaerobic co-digestion using linear regression method显示文摘Alkalinity is a reliable indicator of process stability in anaerobic digestion system.Total alkalinity(TA)and partial alkalinity(PA)are usually monitored offline as indicators for the status of anaerobic digestion process.In order to online monitor TA and PA,the linear regression method was used as estimator to predict alkalinity via software sensor method.Parameters,namely,pH,oxidation and reduction potential(ORP),and electrical conductivity(EC),were used as input variables.EC was the most significant parameter with TA and PA.Multiple linear regression(MLR)models and simple linear regression models with EC were constructed to predict TA and PA in anaerobic co-digestion system.On the basis of the evaluation of prediction accuracy,the applications of linear regression models were better for monitoring PA than TA.MLR models provided higher accuracy for alkalinity prediction than simple linear regression models.The two MLR models based on single-phase anaerobic digestion system were also feasible to predict TA in anaerobic co-digestion systems.However,the accuracy of these models should be improved by calibrating for broad applications of linear regression method in online alkalinity measurement. | Bai Xue Li Zifu Wang Xuemei He Xi Cheng Shikun Bai Xiaofeng Gao Ruiling | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 1 |
| 7 | Structural characterization of a water-insoluble(1,3)-α-D-glucan isolated from the Penicillium chrysongenum显示文摘 | WANG Tianqi DENG Li LI Shikun | 2007 | Carbohydrate Polymer2007，67，： | 1 |
| 8 | Multi-Object Tracking with Micro Aerial Vehicle显示文摘A simple yet efficient tracking framework is proposed for real-time multi-object tracking with micro aerial vehicles(MAVs). It's basic missions for MAVs to detect specific targets and then track them automatically. In our method, candidate regions are generated using the salient detection in each frame and then classified by an eural network. A kernelized correlation filter(KCF) is employed to track each target until it disappears or the peak-sidelobe ratio is lower than a threshold. Besides, we define the birth and death of each tracker for the targets. The tracker is recycled if its target disappears and can be assigned to a new target. The algorithm is evaluated on the PAFISS and UAV123 datasets. The results show a good performance on both the tracking accuracy and speed. | Yufeng Ji Weixing Li Xiaolin Li Shikun Zhang Feng Pan | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 1 |
| 9 | The critical role of m^(6)A methylation in the pathogenesis of Graves'ophthalmopathy显示文摘Purpose:To investigate the role of N6-methyladenosine(m^(6)A)RNA modification in the pathogenesis of Graves'ophthalmopathy(GO).Methods:Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without GO were used.The global m^(6)A levels in the specimens were determined using an m^(6)A RNA methylation quantification kit.RNA sequencing(RNA-seq)was used to analyze the molecules involved in the regulation of m^(6)A RNA methylation and the differential expression of mRNAs between the two groups(4 eyes,respectively).The expression of m^(6)A RNA modification genes was evaluated by real-time PCR.The functional implications of the gene alterations between the GO and control specimens were determined by Gene Ontology analysis.Results:The m^(6)A level was significantly increased in the specimens of GO patients compared to the control specimens(P<0.05).The expression of m^(6)A methylation regulators,such as WT1 associated protein(WTAP),alkylation repair homolog protein 5(ALKBH5),E74 like ETS transcription factor 3(ELF3),YTH N6-methyladenosine RNA binding protein 2(YTHDF2),YTHDF3 and YTH domain containing 2(YTHDC2),was significantly upregulated(P<0.05).Gene Ontology enrichment analysis showed that the most highly upregulated genes and biological pathways were related to the immune response and inflammatory processes such as lymphocyte activation,leukocyte differentiation,cytokine production and cytokine-mediated signaling pathways.Conclusions:Our results suggest that m^(6)A methylation may play a critical role in the pathogenesis of GO and that targeting genes that regulate m^(6)A methylation may provide a new therapeutic approach for GO. | Li Zhu Siyan Li Shikun He Qizhe Tong Lejin Wang Xiaohua Li Xi Wu Qingyu Meng Enzhong Jin Chuan Zhang Tianyuan Li Ningda Xu Lvzhen Huang Yi Wang Mingwei Zhao | 2020 | Eye and Vision2020，7，1： | 1 |
| 10 | Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-α显示文摘 | Man LI Shikun H Vanessa W Ryan S J Hinton DR | 2000 | Invest Ophthalmol Vis Sci2000，41，13： | 1 |
| 11 | Phylogenetic diversity of bacteria associated with the marine sponge Agelas robusta from South China Sea显示文摘It is well known that marine sponges harbor large numbers of bacteria,some of which have been proved to be sponge-specific.The diversity of bacteria in marine sponges distributed along the coast of South China Sea has been previously studied but that of bacteria in sponges inhabiting the open sea has been rarely investigated.In this report,the diversity of bacteria associated with the marine sponge Agelas robusta from a remote coral reef in the South China Sea was documented employing 16S rDNA library construction,amplified ribosomal DNA restriction analysis(ARDRA) and phylogenetic analysis.A total of 32 phylotypes were finally categorized in nine phyla including Cyanobacteria,Proteobacteria,Chloroflexi,Firmicutes,Actinobacteria,Acidobacteria,Planctomycetes,Bacteroidetes and Gemmatimonadetes.The dominant phylum was Proteobacteria whereas the dominant genus was Synechococcus in Cyanobacteria.Some spongespecific bacteria were also found in the bacteria population,but the proportion(5 OTUs/32 OTUs) was much lower than other sponges.This study reveals the phylogenetic diversity of bacteria in A.robusta and confirms the presence of some sponge-specific bacteria in the South China Sea.Understanding the diversity of sponge-associated bacteria in China assists to exploit the bacteria resources for biotechnology. | SUN We DAI Shikun WANG Guanghua XIE Lianwu JIANG Shumei LI Xiang | 2010 | Acta Oceanologica Sinica2010，29，5： | 1 |
| 12 | The essential role of N6-methyladenosine RNA methylation in complex eye diseases显示文摘There are many complex eye diseases which are the leading causes of blindness,however,the pathogenesis of the complex eye diseases is not fully understood,especially the underlying molecular mechanisms of N6-methyladenosine(m6A)RNA methylation in the eye diseases have not been extensive clarified.Our review summarizes the latest advances in the studies of m6A modification in the pathogenesis of the complex eye diseases,including cornea disease,cataract,diabetic retinopathy,age-related macular degeneration,proliferative vitreoretinopathy,Graves’disease,uveal melanoma,retinoblastoma,and traumatic optic neuropathy.We further discuss the possibility of developing m6A modification signatures as biomarkers for the diagnosis of the eye diseases,as well as potential therapeutic approaches. | Xiaohua Li Binyun Ma Wenfang Zhang Zongming Song Xiaodan Zhang Mengyu Liao Xue Li Xueru Zhao Mei Du Jinguo Yu Shikun He Hua Yan | 2023 | Genes & Diseases2023，10，2： | 1 |
| 13 | Synthesis and crystal structure of β-CD and paradioxy benzene显示文摘 | Mat shikun Wang Jinlin Li Aixiu | 2000 | 45(13) : 1383-13862000，45，13： | 1 |
| 14 | Optimization of Thermal Conductivity of Alumina-Filled Composites by Numerical Simulations显示文摘Understanding the correlation between the physical features of composite components and thermal conductive pathway is beneficial to optimizing the overall heat-transfer performance.Herein,we conduct numerical simulation to investigate the thermal conductivity and heat flux distributions of alumina(Al_(2)O_(3))-filled composites.The finite element model was verified by both experimental data and theoretical models.The crucial factors include the influence of the interface thermal resistance,the intrinsic thermal conductivity of the matrix and Al_(2)O_(3)filler,and the size effect of Al_(2)O_(3)fillers were investigated.For single Al_(2)O_(3)-filled composites,the results indicate that increasing the intrinsic thermal conductivity of the matrix is conductive to bridge the Al_(2)O_(3)pathway along heat-transfer direction,but there are very limited contributions by enhancing the intrinsic thermal conductivity of Al_(2)O_(3)filler,tuning the size of Al_(2)O_(3)filler,and reducing the interface thermal resistance.After introducing the multiscale fillers,it is found that the high thermal conductivity can be achieved by regulating their size matching effect.At the optimal binary ratio of 70:30(40µm:15µm)and ternary ratio of 55:35:10(40µm:15µm:10µm),the heat-conduction network presents the dominant skeleton of large-sized filler and the bridging branch of small-sized fillers features,which facilitates the formation of a complete and continuous thermal conductive network.This study gives a practical guidance for the thermal conductive design of Al_(2)O_(3)-filled composites. | LI Shikun LIU Bin JIA Xiao XU Min ZONG Ruoyu LIU Guohua HUAI Xiulan | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 15 | Review of key technologies of climbing robots显示文摘In recent years,the robot industry has developed rapidly,and researchers and enterprises have begun to pay more attention to this industry.People are barely familiar with climbing robots,a kind of special robot.However,from their practical value and scientific research value,climbing robots should studied further.This paper analyzes and summarizes the key technologies of climbing robots,introduces various kinds of climbing robots,and examines their advantages and disadvantages to provide a reference for future researchers.Many countries have studied climbing robots and made some achievements.However,due to the complexity of climbing robots,their climbing efficiency and accuracy need to be further improved.The new structure can improve the climbing efficiency.This paper analyzes climbing robots such as mechanical arms,magnetic attraction,and claws.Optimization methods and path planning can improve the accuracy of work.This paper involves some control methods,including complex intelligent control methods such as behavior-based robot control.This paper also investigates various kinematic planning methods and expounds and summarizes various path planning algorithms,including machine learning and reinforcement learning of artificial intelligence,ant colony algorithm,and other algorithms.Therefore,by analyzing the research status of climbing robots at home and abroad,this paper summarizes three important aspects of climbing robots,namely,structural design,control methods,and climbing strategies,elaborates on the achievements and existing problems of these key technologies,and looks forward to the future development trend and research direction of climbing robots. | Ye DAI Shikun LI Xukun RUI Chaofang XIANG Xinlei NIE | 2023 | Frontiers of Mechanical Engineering2023，18，4： | 0 |
| 16 | Utilization of MSWI fly ash as partial cement or sand substitute with focus on cementing efficiency and health risk assessment显示文摘The strength of cement substituted mortar decreases with the increase in fly ash amount,whereas the strength increases when the fly ash is blended as sand substitute.A mortar with highest strength(compressive strength=30.2 Mpa;flexural strength=7.0 Mpa)was obtained when the sand replacement ratio was 0.75%.The k value(cementing efficiency)of fly ash varied between 0.36 and 0.15 for the fly ash fraction in binder between 5%and 25%.The k values of fly ash used for sand replacement were all significantly above that used for cement substitution.The macropores assigned to the gaps between particles decreased when the fly ash was used as sand replacement,providing an explanation for the strength enhancement.The waste-extraction procedure(toxicity-sulphuric acid and nitric acid method(HJ/T 299-2007))was used to evaluate metal leaching,indicating the reuse possibility of fly ash blended mortar.For the mortar with the mass ratio of fly ash to binder of 0.5%,the carcinogenic risks(CR)and non-carcinogenic hazard quotient(HQ)in sensitive scenario for blended mortar utilization were 9.66 x 10 and 0.06,respectively;these results were both lower than the threshold values,showing an acceptable health risk.The CR(9.89 x 105)and HQ(3.89)of the nonsensitive scenario for fly ash treatment exceeded the acceptable threshold values,indicating health risks to onsite workers.The main contributor to the carcinogenic and non-carcinogenic risk is Cr and Cd,respectively.The CR and HQ from inhalation was the main route of heavy metal exposure. | Lei Zheng Xingbao Gao Wei Wang Zifu Li Lingling Zhang Shikun Cheng | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 0 |
| 17 | Research progress of siloxane removal from biogas显示文摘Siloxanes in biogas are detrimental to engine,turbine,fuel cell,etc.,thus it is necessary to remove siloxanes from biogas before biogas high-value utilization.At present,there are few domestic researches and related reports in view of siloxanes removal from biogas.This paper introduces the property of siloxanes as well as sampling and analysis method,and then presents the research progress of siloxanes removal from biogas.Three commercial technologies overseas are adsorption,absorption and cryogenic condensation.Among them,adsorption on activated carbon is the most widely used method.Other technologies,such as biological removal,catalytic processes,membranes,source controlling,etc.are under exploration and development.At last,this paper summarizes the advantages and disadvantages of siloxanes removal technologies as well as the applicability and analyzes the future research trend and emphasis.This paper could provide a reference in the field of biogas high-value utilization. | Gao Ruiling Cheng Shikun Li Zifu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 0 |
| 18 | Technical Characteristics and Applications of Chuan Style Coring Tools显示文摘TechnicalCharacteristicsandApplicationsofChuanStyleCoringTools￥ZhangShikunandLiBing(DrillincgandProdiictionTechnologi.Researc... | Zhang Shikun and Li Bing(Drillincg and Prodiiction Technologi.Research Instilule. Sichuan Petroleum Adinistralion) | 1995 | China Oil & Gas1995，2，3： | 0 |
| 19 | Mechanism of drilling rate improvement using high-pressure liquid nitrogen jet显示文摘To address the high rock strength and low drilling rate issues in deep oil/gas and geothermal exploitation, we performed mechanical property tests on three kinds of rock samples(granite, shale and sandstone) subjected to liquid nitrogen(LN2) cooling and conducted rock-breaking experiments using LN2 jet. Rock-breaking characteristics and mechanisms of LN2 jet, heat transfer features between LN2 and rock and thermal stress evolution in rock were analyzed. A novel high-pressure LN2 jet assisted drilling method was proposed accordingly. The study results show that LN2 thermal shock can significantly reduce uniaxial compression strength and elastic modulus of rock. Rock damage and corresponding mechanical deterioration become more pronounced with increasing rock temperature. The LN2 jet has merits of high rock-breaking efficiency and low threshold rock-breaking pressure. Rock failure under LN2 jet impact is characterized by large volume breakage and the rock-breaking performance becomes more significant with increase of rock temperature. Under the impact of LN2 jet, the damage of granite is the most remarkable among the three rock samples. Thus, this method works better for high temperature granite formations. It has a good application prospect in speeding up drilling rate in deep hot dry rock geothermal reservoirs. | HUANG Zhongwei WU Xiaoguang LI Ran ZHANG Shikun YANG Ruiyue | 2019 | Petroleum Exploration and Development2019，46，4： | 0 |
| 20 | Ultrathin Metal Silicate Hydroxide Nanosheets with Moderate Metal-Oxygen Covalency Enables Efficient Oxygen Evolution显示文摘Exploring efficient,cost-effective,and durable electrocatalysts for electrochemical oxygen evolution reaction(OER)is pivotal for the large-scale application of water electrolysis.Recent advance has demonstrated that the activity of electrocatalysts exhibits a strong dependence on the surface electronic structure.Herein,a series of ultrathin metal silicate hydroxide nanosheets(UMSHNs)M_(3)Si_(2)O_(5)(OH)_(4)(M=Fe,Co,and Ni)synthesized without surfactant are introduced as highly active OER electrocatalysts.Cobalt silicate hydroxide nanosheets show an optimal OER activity with overpotentials of 287 and 358 m V at 1 and 10 m A cm^(-2),respectively.Combining experimental and theoretical studies,it is found that the OER activity of UMSHNs is dominated by the metal-oxygen covalency(MOC).High OER activity can be achieved by having a moderate MOC as reflected by aσ^(*)-orbital(e_(g))filling near unity and moderate[3d]/[2p]ratio.Moreover,the UMSHNs exhibit favorable chemical stability under oxidation potential.This contribution provides a scientific guidance for further development of active metal silicate hydroxide catalysts. | Jiexin Zhu Shikun Li Zechao Zhuang Shan Gao Xufeng Hong Xuelei Pan Ruohan Yu Liang Zhou Lyudmila V.Moskaleva Liqiang Mai | 2022 | Energy & Environmental Materials2022，5，1： | 0 |
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