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| 1 | NEAT1/miR-140-3p/MAPK1 mediates the viability and survival of coronary endothelial cells and affects coronary atherosclerotic heart disease显示文摘Studies have shown that long non-coding RNAs(lncRNA)play critical roles in coronary atherosclerotic heart disease(CAD).However,the function of lncRNA nuclear enriched abundant transcript 1(NEAT1)in CAD is unclear.In this study,we aimed to investigate the functions of lncRNA NEAT1 in CAD.RTPCR and western blot analysis were carried out to examine the expressions of related RNAs.Colony formation assay,cell proliferation assay,apoptosis assay,and dual-luc讦erase reporter assay were con ducted to investigate the abilities of colony migration,cell proliferatio n,apoptosis,and targeting.The results showed that NEAT1 was up-regulated in CAD blood samples and in human coronary endothelial cells(HCAECs).Transfection of pcNEATI sign讦icantly inhibited the survival rate of HCAECs and induced apoptosis of HCAECs.MiR-140-3p was down-regulated in HCAECs.NEAT1 directly targeted miR-140-3p,and the expression of miR-140-3p was inversely correlated with the expression of NEAT1 in CAD patients.In addition,co-transfection of NEAT1 with miR-140-3p mimic reversed the effect of pcNEATI on cell viability and apoptosis,mitogenactivated protein kinase 1(MAPK1)was proved to be a target gene of miR-140-3p,and the miR-140-3p mimic was shown to reduce the expression of MAPK1 in HCAECs.pcNEATI sigrdficantly increased the expression level of MAPK1,while shNEATI significantly reduced the expression level of MAPK1.Our results revealed that lncRNA NEAT1 increased cell viability and inhibited CAD cell apoptosis possibly by activating the miR-140-3p/MAPK1 pathway,and lncRNA NEAT1 might serve as a potential therapeutic target for CAD. | Hui Zhang Ningning Ji Xinyan Gong Shimao Ni Yu Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 9 |
| 2 | A NEW LOW-COST DEMODULATOR FOR 2.4 GHZ ZIGBEE RECEIVERS显示文摘A new low-cost demodulator for ZigBee receivers satisfying requirements of IEEE802.15.4 standard is presented,which is designed for ISM 2.4 GHz band and based on Zero-IF receivers.This demodulator extracts symbols directly from baseband signal rather than recovering PN code chips,so its structure is simple.Two main techniques are used to improve the performance of demodulator.One is Phase-Axis Crossing Detector(PACD) which detects the phase correlation of baseband signal.The other is symbol synchronization and sampling clock correction algorithm.The result shows that this demodulator performance,Symbol Error Rate(SER) and Packet Error Rate(PER) meet IEEE 802.15.4TM standard requirements and the demodulator can handle frequency offset in excess of 200 kHz,involving a Zero-IF receiver with a Noise Figure(NF) lower than 17 dB,which is easily imple-mented in standard CMOS technology. | Yu Yunfeng Meng Xin Xiao Shimao Ma Chengyan Ye Tianchun | 2009 | Journal of Electronics(China)2009，26，2： | 2 |
| 3 | MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer显示文摘 | Akao Zhu Jiazeng Xia Junbo Zuo Shimao Jin Hong Zhou Lubin Yao Hongyu Huang Zhijun Han | 2012 | Medical Oncology2012，，4： | 2 |
| 4 | Effects of Root Zone Temperature on Growth and Photosynthetic Parameters of Grafted Cucumber显示文摘Taking Cucurbita maxima and Cucurbita moschata as root stocks,and‘Jinyou No 3'cucumber as scion,the effects of different root zone temperature conditions optimal temperature( CK)( 18-20 ℃),suboptimal temperature( 13-15 ℃) and low temperature( 8-10 ℃) on the growth and photosynthesis indexes were studied. The results showed that,compared with optimal temperature( CK),suboptimal temperature and low temperature produced a significant inhibition of growth on cucumbers. The plant height,stem diameter,leaf area,number of leaves and dry weight of aboveground part were all reduced,dry weight of underground part and root shoot ratio all increased,while the inhibition was more significant at low temperature. Low and suboptimal temperature conditions also reduced SPAD value,net photosynthetic rate,transpiration rate,intercellular CO_2 concentration and stomatal conductance of the grafted cucumber. And there were differences between different grafted seedlings,and seedlings with‘black seeds' as stock performed better than those with‘white seeds' as stock at low temperature. | shijun sun shimao cui yang song chongyi fu lihong ye yu gao | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 5 | Diffusion- weighted magnetic resonance imaging of human skeletal muscles: gender-, age- and muscle-related differences in apparent diffusion coefficient 显示文摘 | Yanagisawa O Shimao D Maruyama K | 2009 | Magn Resonance Imaging2009，27，1： | 1 |
| 6 | Benign esophageal schwannoma: report of case显示文摘 | Kobayashi N Kikuchi S Shimao H | 2000 | Surg Tody2000，30，6： | 1 |
| 7 | Symbiotic utilization of polyvinyl alcohol by mixed cultures显示文摘 | Sakazawa C Shimao M Taniguchi Y | 1981 | Applied and Environmental Microbiology1981，41，1： | 1 |
| 8 | Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas:its overexpression in carcinomas and association with invasion fronts显示文摘 | NABESHIMA K SHIMAO Y INOUE T | 2002 | Cancer Lett2002，176，1： | 1 |
| 9 | Magnetic properties of extremely small Nd-Fe-B sintered magnets 显示文摘 | Nakamura H Hirota K Shimao M Minowa T Honshima M | 2005 | IEEE Transactions on Magnetics2005，41，10： | 1 |
| 10 | Cohort migration of carcinoma cell:differentiated colorectal carcinoma cells move as coherent cellclusters or sheets显示文摘 | Nabeshima K Inoue T Shimao Y | 1999 | Histol Histopathol1999，14，： | 1 |
| 11 | Matrix metalloproteinases in tumor invasion: role for cell migration显示文摘 | Nabeshima K Lnoue T Shimao Y | 2002 | Pathol Int2002，52，： | 1 |
| 12 | Studies on factors influencing patient's,doctor's and total delay of tuberculosis casedetection in Japan显示文摘 | Aoki M Mori T Shimao T | 1985 | Bull Int Union Tub1985，60，： | 1 |
| 13 | Matrix metalloproteinases in tumor invasion: role for cell migration显示文摘 | Nabeshima K Inoue T Shimao Y | 2002 | Pathol Int2002，52，4： | 1 |
| 14 | Magnetic properties of extremely small Nd-Fe-B sintered mag- nets显示文摘 | Hajime Nakamura Koichi Hirota Masanobu Shimao | 2005 | IEEE Transactions on Magnetics2005，41，10： | 1 |
| 15 | Properties and role of bacterial symbionts of polyvinyl alcohol utilizing mixed cultures显示文摘 | Shimao M Saimoto H Kato N el al | 1983 | Appl Environ Microbiolm1983，，46： | 1 |
| 16 | X-ray dark field im- aging of human articular cartilage :possible clinical application to orthopedic surgery显示文摘 | Kunisada T Shimao D Sugiyama H | 2008 | Eur J Radiol2008，68，： | 1 |
| 17 | MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1显示文摘 | Jiang Yan Xiaoqiang Guo Jiazeng Xia Tin Shan Chen Gu Zheng Liang Wei Zhao Shimao Jin | 2014 | Medical Oncology2014，，3： | 1 |
| 18 | Biodegradation of plastics显示文摘 | Shimao M | 2001 | Current Opinion in Biotechnology2001，12，： | 1 |
| 19 | Biodegradation of plastics显示文摘 | SHIMAO M | 2001 | Current Opinion in Biotechnology2001，12，3： | 1 |
| 20 | Biodegradation of plastics 显示文摘 | Shimao M | 2001 | Curr Opin Biotechnol2001，12，3： | 1 |
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