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| 1 | Video-based running water animation in Chinese painting style显示文摘This paper presents a novel algorithm for synthesizing animations of running water,such as water-falls and rivers,in the style of Chinese paintings,for applications such as cartoon making. All video frames are first registered in a common coordinate system,simultaneously segmenting the water from background and computing optical flow of the water. Taking artists’ advice into account,we produce a painting structure to guide painting of brush strokes. Flow lines are placed in the water following an analysis of variance of optical flow,to cause strokes to be drawn where the water is flowing smoothly,rather than in turbulent areas: this allows a few moving strokes to depict the trends of the water flows. A variety of brush strokes is then drawn using a template determined from real Chinese paintings. The novel contributions of this paper are:a method for painting structure generation for flows in videos,and a method for stroke placement,with the necessary temporal coherence. | ZHANG SongHai CHEN Tao ZHANG YiFei HU ShiMin MARTIN Ralph | 2009 | Science in China(Series F)2009，52，2： | 8 |
| 2 | Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts显示文摘In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical application.The[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular efflux.Compared to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo.Micro-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node metastases.These results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical evaluation.The feasibility of FAP imaging was demonstrated using PET studies. | Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 3 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，： | 2 |
| 4 | 慢性中性粒细胞白血病诊治进展显示文摘慢性中性粒细胞白血病(CNL)是一种罕见但可致命的慢性骨髓增殖性肿瘤。其临床特征主要包括以中性粒细胞为主的白细胞升高超过25×109/L,且不伴有病态造血或其他骨髓增殖性肿瘤及生理性中性粒细胞升高。CSF3R T618I突变是CSF3R的激活突变。近期的研究揭示了该突变在CNL发病中的重要作用。目前,CSF3R突变已经被纳入CNL诊断标准。其他突变包括SETBP1及ASXL1,也在疾病发病及进展中发挥着重要作用,且对药物治疗的反应有关。个体化治疗时代,CNL的目标是基于疾病临床特征及分子生物学特征的诊断和治疗。 | 宫子木 Shimin HU | 2018 | 中国实用内科杂志2018，38，2： | 2 |
| 5 | Advanced graph model for tainted variable tracking显示文摘The reliability of hardware devices is of critical importance to the overall stability of operating systems.Drivers assume that hardware devices always work normally,but this assumption may cause drivers or systems to crash,since hardware device failures occur frequently.This can lead to incorrect values for drivers and cause them to malfunction.This paper proposes an advanced graph model for tainted variable tracking.The proposed approach can efciently fnd variables,which are related to values read from hardware devices.It can also be used for variable assignment tracking,which is of great beneft in improving the reliability of hardware devices and drivers. | MA Chao YAN Dong WANG YuPing HU ShiMin | 2013 | Science China(Information Sciences)2013，56，11： | 2 |
| 6 | An extension algoRithm for B-spline by curve unclamping显示文摘 | Hu Shimin Tai C L Zhang Songhai | 2002 | Computer-Aided Design2002，34，5： | 1 |
| 7 | Approximate degree reduction of B6zier curves显示文摘 | Hu Shimin Sun Jiaguang Jin Tongguang | 1998 | Tsinghua Science & Technology1998，3，2： | 1 |
| 8 | Optimization approach for 3D model watermarking by linear binary progranaming 显示文摘 | Wang Yuping Hu Shimin | 2010 | Computer Aided Geometric Design2010，27，5： | 1 |
| 9 | Reconstruction of curved solids from engineering drawings显示文摘 | Liu Shixia Hu Shimin Chen Yujian Sun Jiaguang | | 0，，14： | 1 |
| 10 | Preparation and characterization of montmorillonite silica nanocomposites:a sol gel approach to modifying clay surfaces显示文摘 | Qian Zhongzhong Hu Guangjun Zhang Shimin | 2008 | Physica B2008，403，18： | 1 |
| 11 | Surface fitting based on a feature sensitive parametrization显示文摘 | LAI Yukun HU Shimin POTTMANN H | 2006 | Computer-Aided Design2006，38，7： | 1 |
| 12 | A constructive approach to solving 3D geometric constraint systems using dependence analysis显示文摘 | LI Yantao HU Shimin SUN Jiaguang | 2002 | Computer Aided Design2002，34，2： | 1 |
| 13 | Degree reduction of B-spline curves 显示文摘 | Yong Junhai Hu Shimin Sun Jiaguang | 2001 | Computer Aided Geometric Design2001，18，2： | 1 |
| 14 | Approximate degree reduction of B6zier curves 显示文摘 | Hu Shimin Sun Jiaguang Jin Tongguang | 1998 | Tsinghua Science and Technology1998，3，2： | 1 |
| 15 | An extension algorithm for B-spline by curve unelamping显示文摘 | Hu Shimin Tai Chiewlan Zhang Songhai | 2002 | Computer Adided Design2002，34，5： | 1 |
| 16 | An extension algorithm for B-spline by curves unclamping 显示文摘 | Hu Shimin Tai Chiewlan Zhang Songhai | 2002 | Computer Aided Design2002，34，5： | 1 |
| 17 | Trace determination of nine haloacetic acids in drinking water by liquid chromatography–electrospray tandem mass spectrometry显示文摘 | Liping Meng Shimin Wu Fujun Ma Ai Jia Jianying Hu | 2010 | Journal of Chromatography A2010，，29： | 1 |
| 18 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，3： | 1 |
| 19 | Reconstruction of curved solids from engineering drawings显示文摘 | Liu Shixie Hu Shimin Chen Yujian | 2001 | Computer Aided Design2001，33，14： | 1 |
| 20 | Approximate degree reduction of Bézier curves显示文摘 | Hu Shimin Sun Jiaguang Jin Tongguang | 1998 | Tsinghua Science and Technology1998，3，2： | 1 |
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