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| 1 | Multifunctional core/satellite polydopamine@Nd^3+- sensitized upconversion nanocomposite: A single 808 nm near-infrared light-triggered theranostic platform for in vivo imaging-guided photothermal therapy显示文摘重要变细并且过热,在水里由刺激乐队(980 nm ) 的吸收引起了,是主要障碍在在里面做 lanthanide 的 upconversion nanoparticles (UCNP ) 的 vivo 申请。因此,有 808 nm 刺激的适当地组织的 Nd 3+-doped UCNP 能是一种有希望的选择。此处,我们开发了 core-shell-shell 作为成像代理人组织了 Nd 3+-sensitized UCNP,并且装饰了他们到 polydopamine (PDA ) 的表面上构造新奇多功能的核心 / 卫星 nanotheranostic (PDA@UCNPs ) 为在 vivo 成像指导 photothermal 治疗使用单身者 808 nm 激光照耀。core-shell-shell 组织了设计启用的突出的 upconversion 光性质和强壮的 X 光检查变细,从而为优秀 upconversion luminescence/computed 断层摄影术使 nanocomposites 成为潜在的候选人双形式的成像。另外, PDA 核心不仅提供高 photothermal 变换效率和突出的 antitumor 效果,而且由于它的自然特征赋予站台以柔韧的 biocompatibility。因此,这多功能的 nanocomposite 能是在未来 oncotherapy 的有希望的 theranostic,与高治疗学的有效性但是低副作用。这研究将刺激在设计 bio-application-compatible 使多功能的 nanocomposites 感兴趣,特别为在 vivo 的癌症诊断和治疗。 | Xing Ding Jianhua Liu Dapeng Liu Junqi Li Fan Wang Leijiao Li Yinghui Wang Shuyan Song Hongjie Zhang | 2017 | Nano Research2017，10，10： | 16 |
| 2 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 3 | Integral stormwater management master plan and design in an ecological community显示文摘Urban stormwater runoff nearly discharges directly into bodies of water through gray infrastructure in China,such as sewers,impermeable ditches,and pump stations.As urban flooding,water shortage,and other environment problems become serious,integrated water environment management is becoming increasingly complex and challenging.At more than 200 ha,the Oriental Sun City community is a large retirement community located in the eastern side of Beijing.During the beginning of its construction,the project faced a series of serious water environment crises such as eutrophication,flood risk,water shortage,and high maintenance costs.To address these issues,an integral stormwater management master plan was developed based on the concept of low impact development(LID).A large number of LID and green stormwater infrastructure(GSI)approaches were designed and applied in the community to replace traditional stormwater drainage systems completely.These approaches mainly included bioretention(which captured nearly 85th percentile volume of the annual runoff in the site,nearly 5.4×105m3annually),swales(which functioned as a substitute for traditional stormwater pipes),waterscapes,and stormwater wetlands.Finally,a stormwater system plan was proposed by integrating with the gray water system,landscape planning,an architectural master plan,and related consultations that supported the entire construction period.After more than 10 years of planning,designing,construction,and operation,Oriental Sun City has become one of the earliest modern large-scale LID communities in China.Moreover,the project not only addressed the crisis efficiently and effectively,but also yielded economic and ecological benefits. | Wu Che Yang Zhao Zheng Yang Junqi Li Man Shi | 2014 | Journal of Environmental Sciences2014，26，9： | 13 |
| 4 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 5 | Early filiform needle acupuncture for poststroke depression: a meta-analysis of 17 randomized controlled clinical trials显示文摘OBJECTIVE: To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL: We retrieved data from the Chinese National Knowledge Infrastructure(1979–2012), Wanfang(1980–2012), VIP(1989–2012), Chinese Biomedical Literature(1975–2012), PubMed(1966–2012), Ovid Lww(–2012), and Cochrane Library(–2012) Database using the internet. SELECTION CRITERIA: Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the included articles scored at least 4 points on the Jadad scale. Exclusion criteria: other acupuncture therapies as treatment group, not stroke-induced depression patients, score < 4 points, non-randomized controlled trials, or animal trials. MAIN OUTCOME MEASURES: These were the Hamilton Depression Scale scores, clinical effective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS: A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with filiform needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval(CI): 1.03–1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale(17 items) scores were lower than in the antidepressant drug group(mean difference =-2.34, 95%CI:-3.46 to-1.22, P < 0.000,1). At 4 weeks, Hamilton Depression Scale(24 items) scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 articles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION: Early filiform needle acupuncture for poststroke depression can perfectly control depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs. | Jiping Zhang Jing Chen Junqi Chen Xiaohui Li Xueyan Lai Shaoqun Zhang Shengxu Wang | 2014 | Neural Regeneration Research2014，9，7： | 11 |
| 6 | Hepatitis C virus core protein triggers expansion and activation of CD4+CD25+ regulatory T cells in chronic hepatitis C patients显示文摘 | Naicui Zhai Xiumei Chi Tianyang Li Hongxiao Song Haijun Li Xia Jin Ian Nicholas Crispe Lishan Su Junqi Niu Zhengkun Tu | 2015 | Cellular & Molecular Immunology2015，12，6： | 10 |
| 7 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 8 | Effects of Cr Content on the Microstructure and Properties of 26Cr–3.5Mo–2Ni and 29Cr–3.5Mo–2Ni Super Ferritic Stainless Steels显示文摘By using scanning electron microscopy,energy-dispersive spectrometry,X-ray diffraction,strength and hardness measurements,the microstructure,precipitation,mechanical properties,and corrosion resistance have been investigated for two super ferritic stainless steels,26Cr–3.5Mo–2Ni and 29Cr–3.5Mo–2Ni,with the aim to consider the effect of Cr content.The results showed that with the addition of Cr content,the recrystallization temperature was increased;the precipitation of Laves and Sigma(σ)phases was promoted and the mechanical properties of super ferritic stainless steel were modified.Furthermore,the pitting corrosion resistance and corrosion resistance to H_2SO_4 of the two super ferritic stainless steels were improved.In addition,suitable annealing processing is a key factor to maintain integrated performance by optimizing microstructure and removing detrimental precipitation phases. | Li Ma Shengsun Hu Junqi Shen Jian Han Zhixiong Zhu | 2016 | Journal of Materials Science & Technology2016，32，6： | 8 |
| 9 | Is urban development an urban river killer? A case study of Yongding Diversion Channel in Beijing, China显示文摘The high population and concrete environment alter urban areas by changing temperature, rainfall runoff, and water resource utilization activities. This study was conducted to investigate the water quality features of the Yongding Diversion Channel in Beijing, China, and its relationship with rainfall and urban development. Monthly water quality data were obtained from April to October of 2004 at monitoring sites of Sanjiadian, Gaojing, Luodaozhuang, and Yuyuangtan. The monthly water quality grades from 2007 to 2011 were also investigated and compared with those of other rivers. Dissolved oxygen and pH showed greater decreases after one or two moderate rainfall events than several light rainfall events. The potassium permanganate index(CODMn), ammonia nitrogen(NH3-N) and total phosphorus(TP) increased more after several light rainfall events than after one or two moderate or heavy rainfall events. Pollutant concentrations(CODMn, NH3-N, TP) in downstream regions showed greater changes than those in upstream areas after heavy rainfall events. Intense human activities around the channel greatly influenced the water quality of the channel in rainy season because of runoff pollution; however, heavy rainfall had a strong dilution effect on the pollutant concentrations in rivers. Overall, urban development has obviously deteriorated the water quality of the Yongding Diversion Channel as indicated by an increase in the water quality index from 3.22 in 2008 to 4.55 in2010. The Pearson correlation between monthly rainfall and water quality indices from 2007 to 2011ranged from 0.1286 to 0.6968, generally becoming weaker as rainfall and rainfall runoff became more random and extreme. | Xi Wang Junqi Li Yingxia Li Zhenyao Shen Xuan Wang Zhifeng Yang Inchio Lou | 2014 | Journal of Environmental Sciences2014，26，6： | 8 |
| 10 | Expert consensus on dental caries management显示文摘Dental Caries is a kind of chronic oral disease that greatly threaten human being’s health.Though dentists and researchers struggled for decades to combat this oral disease,the incidence and prevalence of dental caries remain quite high.Therefore,improving the disease management is a key issue for the whole population and life cycle management of dental caries.So clinical difficulty assessment system of caries prevention and management is established based on dental caries diagnosis and classification.Dentists should perform oral examination and establish dental records at each visit.When treatment plan is made on the base of caries risk assessment and carious lesion activity,we need to work out patient-centered and personalized treatment planning to regain oral microecological balance,to control caries progression and to restore the structure and function of the carious teeth.And the follow-up visits are made based on personalized caries management.This expert consensus mainly discusses caries risk assessment,caries treatment difficulty assessment and dental caries treatment plan,which are the most important parts of caries management in the whole life cycle. | Lei Cheng Lu Zhang Lin Yue Junqi Ling Mingwen Fan Deqin Yang Zhengwei Huang Yumei Niu Jianguo Liu Jin Zhao Yanhong Li Bin Guo Zhi Chen Xuedong Zhou | 2022 | International Journal of Oral Science2022，14，2： | 8 |
| 11 | Effects of Microalloying and Heat-Treatment Temperature on the Toughness of 26Cr–3.5Mo Super Ferritic Stainless Steels显示文摘The effects of Ni content and heat-treatment process on the toughness of a super ferritic stainless steel with26 wt% Cr and 3.5 wt% Mo were investigated. It was found that with the increase of Ni content, the Charpy impact toughness improved remarkably, and transformed from cleavage brittle fracture to the most ductile fracture. There were no obvious differences between the high- and low-Ni contents on the microstructure and mechanical properties since the addition of Ni did not influence crystal structure, phase composition, and precipitation of ultra pure ferritic stainless steels.Meanwhile, the heat-treatment process was a key point to maintain a high level of toughness by optimizing structure and removing detrimental precipitation, i.e., chi phase. | Li Ma Jian Han Junqi Shen Shengsun Hu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，3： | 6 |
| 12 | Blind position detection for large field-of-view scattering imaging显示文摘Prio-free imaging beyond the memory efect(ME)is critical to seeing through the scattering media.However,methods proposed to exceed the ME range have suffered from the availability of prior information of imaging targets.Here,we propose a blind target position detection for large field-of-view scattering imaging.Only exploiting two captured multi-target near field speckles at diferent imaging distances,the unknown number and locations of the isolated imaging targets are blindly reconstructed via the proposed scaling vecto-based detection.Autocorrelations can be calculated for the speckle regions centered by the derived positions via low.cross talk region allocation strategy.Working with the modified phase retrieval algorithm,the complete scene of the multiple targets exceeding the ME range can be reconstructed without any prior information.The effectiveness of the proposed algorithm is verified by testing on a real scattering imaging system. | XIAOYU WANG XIN JIN JUNQI LI | 2020 | Photonics Research2020，8，6： | 6 |
| 13 | Expert consensus on regenerative endodontic procedures显示文摘Regenerative endodontic procedures(REPs)is a biologic-based treatment modality for immature permanent teeth diagnosed with pulp necrosis.The ultimate objective of REPs is to regenerate the pulp-dentin complex,extend the tooth longevity and restore the normal function.Scientific evidence has demonstrated the efficacy of REPs in promotion of root development through case reports,case series,cohort studies,and randomized controlled studies.However,variations in clinical protocols for REPs exist due to the empirical nature of the original protocols and rapid advancements in the research field of regenerative endodontics.The heterogeneity in protocols may cause confusion among dental practitioners,thus guidelines and considerations of REPs should be explicated.This expert consensus mainly discusses the biological foundation,the available clinical protocols and current status of REPs in treating immature teeth with pulp necrosis,as well as the main complications of this treatment,aiming at refining the clinical management of REPs in accordance with the progress of basic researches and clinical studies,suggesting REPs may become a more consistently evidence-based option in dental treatment. | Xi Wei Maobin Yang Lin Yue Dingming Huang Xuedong Zhou Xiaoyan Wang Qi Zhang Lihong Qiu Zhengwei Huang Hanguo Wang Liuyan Meng Hong Li Wenxia Chen Xiaoying Zou Junqi Ling | 2022 | International Journal of Oral Science2022，14，4： | 5 |
| 14 | First-principles Study of NiAl Alloyed with Rare Earth Element Ce显示文摘The structural, elastic, and electronic properties of NiAl alloyed with rare earth element (REE) Ce have been investigated by using density functional theory (DFT). It is found that Ce has a strong Al site preference and causes lattice distortion of NiAl. The calculation of elastic constants shows that Ce increased both the hardness and the ductility of NiAl, which could be explained by the formation of new ionic bonds between Al (and Ni) and Ce and the enhancement of covalent bonds in Ni8Al7Ce. Our results are in good agreement with the available experimental data and other theoretical results. | You Wang Junqi He Mufu Yan Chonggui Li Liang Wang YeZhou | 2011 | Journal of Materials Science & Technology2011，27，8： | 5 |
| 15 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 16 | Mass production of Co3O4@CeO2 core@shell nanowires for catalytic CO oxidation显示文摘在这研究,公司 3 O 4@CeO2 core@shell nanowires 成功地经由公司的热分解被准备(公司 3)0.5(OH) | Jiangman Zhen Xiao Wang Dapeng Liu Zhuo Wang Junqi Li Fan Wang Yinghui Wang Hongjie Zhang | 2015 | Nano Research2015，8，6： | 4 |
| 17 | Online adaptive Q-learning method for fully cooperative linear quadratic dynamic games显示文摘A model-based offline policy iteration(PI) algorithm and a model-free online Q-learning algorithm are proposed for solving fully cooperative linear quadratic dynamic games. The PI-based adaptive Q-learning method can learn the feedback Nash equilibrium online using the state samples generated by behavior policies, without sending inquiries to the system model. Unlike the existing Q-learning methods, this novel Q-learning algorithm executes both policy evaluation and policy improvement in an adaptive manner.We prove the convergence of the offline PI algorithm by proving its equivalence to Newton’s method while solving the game algebraic Riccati equation(GARE). Furthermore, we prove that the proposed Q-learning method will converge to the Nash equilibrium under a small learning rate if the method satisfies certain persistence of excitation conditions, which can be easily met by suitable behavior policies. Our simulation results demonstrate the good performance of the proposed online adaptive Q-learning algorithm. | Xinxing LI Zhihong PENG Lei JIAO Lele XI Junqi CAI | 2019 | Science China(Information Sciences)2019，62，12： | 4 |
| 18 | Overwhelming low ammonia escape and low temperature denitration efficiency via MnOx-decorated two-dimensional MgAl layered double oxides显示文摘Low temperature catalysts are attracting increasing attention in the selective catalytic reduction(SCR)of NO with NH3.Mn Ox-decorated Mg Al layered double oxide(Mn/Mg Al-LDO)was synthesized via a facile fast pour assisted co-precipitation(FP-CP)process.Compared to the Mn/Mg Al-LDO obtained via slow drop assisted coprecipitation(SD-CP)method,the Mn/Mg Al-LDO(FP-CP)has excellent activity.The Mn/Mg Al-LDO(FP-CP)catalyst was shown to possess a high NO conversion rate of 76%-100%from 25 to 150℃,which is much better than the control Mn/Mg Al-LDO(SD-CP)(29.4%-75.8%).In addition,the Mn/Mg Al-LDO(FP-CP)offered an enhanced NO conversion rate of 97%and a N2selectivity of 97.3%at 100℃;the NO conversion rate was 100%and the N2selectivity was 90%at 150℃with a GHSV of 60,000 h^-1.The Mn/Mg Al-LDO(FP-CP)catalyst exhibited a smaller fragment nano-sheet structure(sheet thickness of 7.23 nm).An apparent lattice disorder was observed in the HRTEM image confirming the presence of many defects.The H2-TPR curves show that the Mn/Mg Al-LDO(FP-CP)catalyst has abundant reducing substances.Furthermore,the enhanced surface acidity makes the NH3concentration of the Mn/Mg Al-LDO(FP-CP)catalyst lower than 100 ml·m^-3after the reaction from 25 to 400℃.This can effectively reduce the ammonia escape rate in the SCR reaction.Thus,the Mn/Mg Al-LDO(FP-CP)catalyst has potential applications in stationary industrial installations for environmentally friendly ultra-low temperature SCR. | Junqi Tian Yanqin Li Xia Zhou Yongbin Yao DenghaoWang Jianming Dan Bin Dai Qiang Wang Feng Yu | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 4 |
| 19 | Preclinical evaluation and pilot clinical study of [^(18)F]AlF-labeled FAPI-tracer for PET imaging of cancer associated fibroblasts显示文摘In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel^(18)Flabeled FAP tracer([^(18)F]Al F-P-FAPI)for FAP imaging and evaluated its potential for clinical application.The[^(18)F]Al F-P-FAPI novel tracer was prepared in an automated manner within 42 min with a non-decay corrected radiochemical yield of 32±6%(n=8).Among A549-FAP cells,[^(18)F]Al F-P-FAPI demonstrated specific uptake,rapid internalization,and low cellular efflux.Compared to the patent tracer[^(18)F]FAPI-42,[^(18)F]Al F-P-FAPI exhibited lower levels of cellular efflux in the A549-FAP cells and higher stability in vivo.Micro-PET imaging in the A549-FAP tumor model indicated higher specific tumor uptake of[^(18)F]Al F-P-FAPI(7.0±1.0%ID/g)compared to patent tracers[^(18)F]FAPI-42(3.2±0.6%ID/g)and[68 Ga]Ga-FAPI-04(2.7±0.5%ID/g).Furthermore,in an initial diagnostic application in a patient with nasopharyngeal cancer,[^(18)F]Al F-P-FAPI and[^(18)F]FDG PET/CT showed comparable results for both primary tumors and lymph node metastases.These results suggest that[^(18)F]Al F-P-FAPI can be conveniently prepared,with promising characteristics in the preclinical evaluation.The feasibility of FAP imaging was demonstrated using PET studies. | Kongzhen Hu Junqi Li Lijuan Wang Yong Huang Li Li Shimin Ye Yanjiang Han Shun Huang Hubing Wu Jin Su Ganghua Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 20 | Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer显示文摘Electroactive bacteria could perform bi-directional extracellular electron transfer(EET)to exchange electrons and energy with extracellular environments,thus playing a central role in microbial electro-fermentation(EF)process.Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels.However,the low efficiency of the bi-directional EET is a dominating bottleneck in these processes.In this review,we firstly demonstrate the main bi-directional EET mechanisms during EF,including the direct EET and the shuttle-mediated EET.Then,we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail.Furthermore,we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis,thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis.Lastly,a perspective on the applications of microbial electro-fermentation is provided. | Ziying Gong Huan Yu Junqi Zhang Feng Li Hao Song | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 4 |
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