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| 1 | Gas Hydrates in the Qilian Mountain Permafrost, Qinghai, Northwest China显示文摘Qilian Mountain permafrost, with area about 10×104 km2, locates in the north of Qinghai-Tibet plateau. It equips with perfect conditions and has great prospecting potential for gas hydrate. The Scientific Drilling Project of Gas Hydrate in Qilian Mountain permafrost, which locates in Juhugeng of Muri Coalfield, Tianjun County, Qinghai Province, has been implemented by China Geological Survey in 2008–2009. Four scientific drilling wells have been completed with a total footage of 2059.13 m. Samples of gas hydrate are collected separately from holes DK-1, DK-2 and DK-3. Gas hydrate is hosted under permafrost zone in the 133–396 m interval. The sample is white crystal and easily burning. Anomaly low temperature has been identified by the infrared camera. The gas hydrate-bearing cores strongly bubble in the water. Gas-bubble and water-drop are emitted from the hydrate-bearing cores and then characteristic of honeycombed structure is left. The typical spectrum curve of gas hydrate is detected using Raman spectrometry. Furthermore, the logging profile also indicates high electrical resistivity and sonic velocity. Gas hydrate in Qilian Mountain is characterized by a thinner permafrost zone, shallower buried depth, more complex gas component and coal-bed methane origin etc. | ZHU Youhai ZHANG Yongqin WEN Huaijun LU Zhenquan JIA Zhiyao LI Yonghong LI Qinghai LIU Changling WANG Pingkang GUO Xingwang | 2010 | Acta Geologica Sinica(English Edition)2010，84，1： | 19 |
| 2 | Regulation of inflammation and tumorigenesis by the FIPE family of phospholipid transfer proteins显示文摘 | Jason R Goldsmith Youhai H Chen | 2017 | Cellular & Molecular Immunology2017，14，6： | 15 |
| 3 | Gas Sources of Natural Gas Hydrates in the Shenhu Drilling Area, South China Sea: Geochemical Evidence and Geological Analysis显示文摘The Shenhu gas hydrate drilling area is located in the central Baiyun sag, Zhu Ⅱ depression, Pearl River Mouth basin, northern South China Sea. The gas compositions contained in the hydrate-bearing zones is dominated by methane with content up to 99.89% and 99.91%. The carbon isotope of the methane (δ13C1 ) are 56.7‰ and 60.9‰, and its hydrogen isotope (δD) are 199‰ and 180‰, respectively, indicating the methane from the microbial reduction of CO2 . Based on the data of measured seafloor temperature and geothermal gradient, the gas formed hydrate reservoirs are from depths 24-1699 m below the seafloor, and main gas-generation zone is present at the depth interval of 416-1165 m. Gas-bearing zones include the Hanjiang Formation, Yuehai Formation, Wanshan Formation and Quaternary sediments. We infer that the microbial gas migrated laterally or vertically along faults (especially interlayer faults), slump structures, small-scale diapiric structures, regional sand beds and sedimentary boundaries to the hydrate stability zone, and formed natural gas hydrates in the upper Yuehai Formation and lower Wanshan Formation, probably with contribution of a little thermogenic gas from the deep sedments during this process. | ZHU Youhai HUANG Xia FU Shaoying SU Pibo | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 13 |
| 4 | 在由巨噬细胞并且从而的增加的 IL-10 表示的规划房间死亡 4 结果的缺乏在 hyperlipidemic 鼠标稀释动脉粥样硬化显示文摘(Pdcd4 ) 规划房间死亡 4 是抄写和翻译和肿瘤 suppressor 的一个最新定义的禁止者。最近的研究建议了 Pdcd4 可以也涉及一些煽动性的疾病。然而,它在动脉粥样硬化的角色,动脉的墙的长期的发炎,尚待被调查。这里,我们发现在老鼠的那 Pdcd4 缺乏在巨噬细胞增加了 IL-10 的表示并且减少在 T 房间的 IL-17 的表示面对在 vitro 并且在高导致脂肪的动脉粥样硬化患者匾的一个联系动脉粥样硬化的激发器。重要地,击倒 Pdcd4 在喂的 Apoe −/− 老鼠在动脉粥样硬化患者损害导致了减少一本高胖的食谱。这效果能被与抵销的抗体堵住 IL-10 然而并非由外长的 IL-17 的申请部分颠倒。进一步机械学的研究表明 Pdcd4 否定地以一种 ERK1/2 依赖、 p38 依赖的方式调整了 IL-10 的表示。这些结果证明那 Pdcd4 缺乏通过反煽动性的 cytokine IL-10 的 upregulation 部分地在 hyperlipidemic 老鼠稀释动脉粥样硬化。这显示内长的 Pdcd4 支持动脉粥样硬化因此与动脉粥样硬化为病人代表一个潜在的治疗学的目标。 | Yang Jiang Qi Gao Liyang Wang Chun Guo Faliang Zhu Bo Wang Qun Wang Fei Gao Youhai Chen Lining Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 5 | Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins显示文摘In this article,the name of an author was listed incorrectly.The author names should have been listed as Jason R Goldsmith,Svetlana Fayngerts and Youhai H Chen.The authors regret the errors. | Jason R Goldsmith Youhai H Chen | 2017 | Cellular & Molecular Immunology2017，14，12： | 8 |
| 6 | Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL显示文摘The purpose of this study is to observe the effects of HBx on the apoptosis of hepatoma cells induced by TNF-related apoptosis-inducing ligand (TRAIL) and to study prelimi- nary molecular mechanisms for its effects. In order to set up a model in vitro, BEL7402-HBx cell line, stably expressing HBx mRNA, was established by stable transfection of pcDNA-HBx, which contains HBx gene, into hepatoma cell line BEL7402. Control cell line BEL7402-cDNA3, stably transfected with pcDNA3, was set up simultaneously as a control. Trypan blue exclusion test, caspase 3 activity detection and TUNEL assay were performed to detect the apoptosis of BEL7402, BEL7402-cDNA3, BEL7402-HBx induced by TRAIL. The expression of TRAIL recep- tors in three groups was analyzed by Flow cytometry. In addition, phosphorothioated antisense oligonucleotide against the translation initial region of HBx gene (PS-asODNs/HBx) was used to block the expression of HBx in HepG2.2.15 cells and to further confirm the effects of HBx on TRAIL-induced apoptosis. Trypan blue exclusion test indicated that TRAIL had a dose-dependent cytotoxicity on BEL7402, BEL7402-cDNA3 and BEL7402-HBx cells. Under treatment of the same concentration of TRAIL, BEL7402-HBx had a higher apoptosis rate and a higher level of Caspase 3 activation than BEL7402 and BEL7402-cDNA3. TUENL assay showed that the apoptosis rate of BEL7402-HBx induced by 10 μg/L TRAIL was 41.4%±7.2%, signifi- cantly higher than that of BEL7402 and BEL7402-cDNA3 cells. Blockade of HBx expression in Hep G2.2.15 cells partly inhibited the apoptosis induced by TRAIL. The introduction or blockade of HBx did not change the expression pattern of TRAIL receptors. The present study firstly con- firms the effects of HBx on TRAIL- induced apoptosis from two different points and it is not re- lated with the expression level of TRAIL receptors. This would be useful to further clarify the roles of imbalanced apoptosis in pathogenesis of Hepatitis B and related hepatocellular carcinoma. | LIANG Xiaohong 1 , SUN Wensheng 1 , GAO Lifen 1 , MA Chunhong 1 , HAN Lihui 1 & CHEN Youhai 2 1. Institute of Immunology, Medical School of Shandong University, Jinan 250012, China 2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia PA19104, USA | 2005 | Science China(Life Sciences)2005，48，3： | 7 |
| 7 | Geochemistry and genesis of authigenic pyrite from gas hydrate accumulation system in the Qilian Mountain permafrost, Qinghai, northwest China显示文摘A type of authigenic pyrites that fully fill or semi-fill the rock fractures of drillholes with gas hydrate anomalies are found in the Qilian Mountain permafrost; this type of pyrite is known as 'fracture-filling' pyrite. The occurrence of 'fracture-filling' pyrite has a certain similarity with that of the hydrate found in this region, and the pyrite is generally concentrated in the lower part of the hydrate layer or the hydrate anomaly layer. The morphology, trace elements, rare earth elements, and sulfur isotope analyses of samples from drillhole DK-6 indicate that the 'fracture-filling' pyrites are dominated by cubic ones mainly aligned in a step-like fashion along the surfaces of rock fractures and are associated with a circular structure, lower Co/Ni and Sr/Ba, lower ?REE, higher LREE, significant Eu negative anomalies, and ? 34 SCDT positive bias. In terms of the pyrites' unique crystal morphology and geochemical characteristics and their relationship with the hydrate layers or abnormal layers, they are closely related with the accumulation system of the gas hydrate in the Qilian Mountain permafrost. As climate change is an important factor in affecting the stability of the gas hydrate, formation of fracture-filling pyrites is most likely closely related to the secondary change of the metastable gas hydrate under the regional climate warming. The distribution intensity of these pyrites indicates that when the gas hydrate stability zone(GHSZ) is narrowing, the hydrate decomposition at the bottom of the GHSZ is stronger than that at the top of the GHSZ, whereas the hydrate decomposition within the GHSZ is relatively weak. Thus, the zone between the shallowest and the deepest distribution of the fracture-filling pyrite recorded the largest possible original GHSZ. | WANG PingKang ZHU YouHai LU ZhenQuan HUANG Xia PANG ShouJi ZHANG Shuai JIANG ShaoQing LI QingHai YANG KaiLi LI Bing | 2014 | Science China Earth Sciences2014，57，9： | 6 |
| 8 | Development mechanism of internal local corrosion of X80 pipeline steel显示文摘The occurrence and development mechanism of internal local corrosion has always been a controversial topic,and especially under flow conditions.In this paper,an improved high shear force loop was experimentally used,and local flow field is induced by simulating corrosion defects on the surface of X80 pipeline steel specimens.The characteristics of corrosion products deposited on the surface of specimens in CO2-saturated NACE solution were investigated by means of electrochemical impedance spectroscopy(EIS),scanning electron microscopy(SEM),X-ray diffraction(XRD),and energy dispersive spectrometry(EDS).The 3D micromorphology of the corrosion test surface after remove the corrosion scale used to measure the size of localized corrosion pit.Under the influence of local defects,the wall shear stress(WSS)and turbulent kinetic energy of local flow fields enhanced significantly,and pressure fluctuations in local flow field were induced.The results showed that the characteristics of surface corrosion products varied with flow velocity.The corrosion scales formed in various regions of specimens with defects exhibited different surface micro-morphologies and chemical compositions.Overall,these data offer new perspectives for better understanding the mechanisms behind local corrosion. | Zhuowei Tan Liuyang Yang Dalei Zhang Zhenbo Wang Frank Cheng Mingyang Zhang Youhai Jin | 2020 | Journal of Materials Science & Technology2020，47，14： | 6 |
| 9 | Heat oscillation in the upper ocean of the southern South China Sea显示文摘Data used in this study are temperature/depth profiles taken over the upper 400 m of the ocean in the southern South China Sea (4°-14° N, 106°-120° E) for the period 1961-1973. The data are analyzed on the grid 2 (latitude) by 2 (longitude) in space and bimonthly in time. The vertically averaged temperature (TAV) over the upper 100 m of the ocean is calculated as the estimate of the heat content in the upper ocean.The TAV is cooler in the northwest region of the study area and warmer in the southeast in the annual and seasonal mean figures. The first EOF (Empirical Orthogonal Function) of anomalous TAV accounts for 41 % of the total variance for the period 1961-1973. The time function associated with it displays a significant interannual changes in the heat content, with 2-4 a oscillation period and associated with the ENSO events. During ENSO event TAV increases with the tendency of increasing towards equator along the basin. This anomalous states also exist in the water layers below 100 m depth. | He Youhai, Guan Cuihua and Gan Zijun South China Sea Institute of Oceanology, Academia Sinica, Guangzhou 510301, China | 1992 | Acta Oceanologica Sinica1992，11，3： | 5 |
| 10 | Geochemical Indications of Possible Gas Hydrates in the Northeastern South China Sea显示文摘煤气的水合物,主要烃气体和水创作了,被认为是在第 21 世纪的一个干净精力。象 BSR (模仿底部的思考) 那样的许多指示物,被认为与煤气的水合物有关,在最近的年里在华南海(SCS ) 被发现。SCS 的东北部分被许多科学家在区域作为大多数潜力之一拿。它位于北分叉的大陆人边缘和东方会聚的岛边缘的连词,其地质的背景更好让煤气的水合物发生。通过这研究,亮度温度异例由基于卫星的热红外线的遥远地察觉到的图象记录了在前或在逼近的地震,从表面下的沉积排除酸的烃气体满意的高度和表面下的沉积的放射性的热照明价值在这个区域被发现的高度以内。有时,亮度温度异例独自在包围 Dongsha 岛存在。到 393 亩 L 甲烷的烃气体数量的最高的内容每公斤沉积和最高放射性的热照明珍视是 31752 单位;他们的几何一般水准分别地是 60.5 亩 L/kg 和 2688.9 单位。是更鼓舞人心的的,是有三个地点,甲烷内容直到 243, 268 并且 359mu L/kg 和他们的放射性的热照明价值分别地是 8430,9537 和 20826 单位。这三个地点只在前辈识别的最高充满信心的 BSR 之一的附近。同时,异例在在这个地点的孔隙水与象在沉积和氯化物异例的 headspacegas 异例那样的另外的结果通常是重合的 1146 Leg184。上述异例是最可能在东北 SCS 显示煤气的水合物的出现。 | LU Zhengquan WU Bihao ZHU Youhai QIANG Zuji WANG Zaimin ZHANG Fuyuan | 2006 | Acta Geologica Sinica(English Edition)2006，80，4： | 4 |
| 11 | COVID-19:immunopathogenesis and Immunotherapeutics显示文摘The recent novel coronavirus disease(COVID-19)outbreak,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is seeing a rapid increase in infected patients worldwide.The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations.SARS-CoV-2 not only activates antiviral immune responses,but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19,leading to lymphopenia,lymphocyte dysfunction,and granulocyte and monocyte abnormalities.These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms,septic shock,and severe multiple organ dysfunction.Therefore,mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease.Moreover,rational management of the immune responses to SARSCoV-2,which includes enhancing anti-viral immunity while inhibiting systemic inflammation,may be key to successful treatment.In this review,we discuss the immunopathology of COVID-19,its potential mechanisms,and clinical implications to aid the development of new therapeutic strategies against COVID-19. | Li Yang Shasha Liu Jinyan Liu Zhixin Zhang Xiaochun Wan Bo Huang Youhai Chen Yi Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 12 | Improvement of CO2 capture performance of calcium-based absorbent modified with palygorskite显示文摘Limestone can be used for CO_2 capture and sequestration(CCS) in flue gas effectively. However, its CCS capability will dramatically decline after several cycles due to the surface 'sintering'. In this work, the limestone was modified with palygorskite to reduce sintering phenomenon between the absorbent particles during the CCS process and the carbonation rate of the limestone can be enhanced effectively. Palygorskite is a natural mineral with nano-fibrous structure which can reduce the mutual contact of limestone particles during the CCS process. The results were detected by TGA, SEM, MIP, FTIR and particle size analyzer respectively. The best CO_2 capture performance of modified absorbent was 13.11% improvement with only 5 wt% palygorskite added during the CCS process after 15 cycles compared with natural absorbent. It was found that excellent microscopic structures of absorbent modified with palygorskite was created, and the surface sintering was postponed leading to CO_2 capture performance enhanced under the same conditions. | Liyuan Shan Hui Li Binglu Meng Youhai Yu Yonggang Min | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 4 |
| 13 | A GIS-based Earthquake and Tsunami Emergency Command System for Seaside Cities显示文摘在这篇论文,地理信息系统(GIS ) 被用于地震和地震和海啸紧急情况命令系统(ETECS ) 因为海滨城市被开发它一个基本数据库和六个分系统是镇静的。Byemploying 这个系统,负责的市政的部门罐头在地震或海啸的出现前做快速的预言,成为在灾难性的事件期间有关灾难战斗命令决定,并且做伤亡和经济损失的快速的估计。以便政府能及时进行救济工作并且为未来灾难减小和预防计划。 | GUAN Youhai FENG Qimin JIA Jing | 2006 | Journal of Ocean University of China2006，5，2： | 3 |
| 14 | Maintaining immunological tolerance with Foxp3显示文摘在胸腺的中央忍耐是为删除汽车的主要机制反应 T 房间。尽管有这,进圆周的自我反应的 T 淋巴细胞的逃跑揭示汽车免疫的威胁。补偿它的瑕疵,胸腺也与镇压功能生产 Foxp3+CD4+CD25+ 规章的 T 房间的一个自然地发生的子集,能够控制汽车反应房间。Foxp3 (叉头框 P3 ) ,为房间的这个子集的系特定的标记,对他们的 thymic 开发和外部功能关键,并且还 Foxp3 驾驶的 transcriptional 程序直到现在大部分未定义。新兴的证据提供了卓见进它的角色:从 Foxp3 到的能力与象 NFAT 那样的另外的抄写因素合作,到目标的染色体宽的描述,基因直接由 Foxp3 跳了并且调整。这里,我们讨论自然地发生的规章的 T 房间的发现 - 他们的显型,发展,维护,和功能 - 大部分当他们被系特定的标记定义, Foxp3。 | Lauren E Mays Youhai H Chen | 2007 | Cell Research2007，17，11： | 3 |
| 15 | The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras显示文摘 | Yael Gus-Brautbar Derek Johnson Li Zhang Honghong Sun Peng Wang Shirley Zhang Lining Zhang Youhai H. Chen | 2012 | Molecular Cell2012，，5： | 2 |
| 16 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，： | 2 |
| 17 | Organoid Technology and Clinical Applications in Digestive System Cancer显示文摘Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality worldwide.Current cancer models cannot faithfully recapitu-late the critical features of the original tumor,resulting in the failure of translation from basic research into clinical practice.More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development.Organoids are in vitro cultured three dimensional(3D)self-organizing organotypic structures derived from tissues and pluripotent stem cells,which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues.Both normal and malignant organoids can now be efficiently established from the DS tissues of patients.In this review,we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research,preclinical medical practice,and precision medicine. | Xiaofang Zhao Youhai Jiang Chunliang Liu Minghui Hou Hongyang Wang Jing Fu | 2022 | Engineering2022，8，2： | 2 |
| 18 | A review on the gas hydrate research in China 显示文摘 | Tianmin Guo Bihao Wu Youhai Zhu | 2004 | Journal of Petroleum Science and Engineering2004，41，： | 1 |
| 19 | A review on the gas hydrate research in China 显示文摘 | GUO Tianmin WU Bihao ZHU Youhai | 2004 | Journal of Petroleum Science and Engineering2004，41，： | 1 |
| 20 | Heavy metal contamination in western Xiamen Bay sediments and its vicinity, China显示文摘 | Luoping Zhang Xin Ye Huan Feng Youhai Jing Tong Ouyang Xingtian Yu Rongyuan Liang Chengtie Gao Weiqi Chen | 2007 | Marine Pollution Bulletin2007，，7： | 1 |
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