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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 3 | Assessing the carbon footprint of water production 显示文摘 | Strutt J Wilson S Shomey'-Darby H | 2008 | Journal of the American Water Works Association2008，100，6： | 1 |
| 4 | Removal of Mercury from Coal by Mild Pyrolysis and Leaching Behavior of Mercury 显示文摘 | Akira Iwashita Shomei Tanamachi Tsunenori Nakajima | 2004 | Fuel2004，，83： | 1 |
| 5 | Release Behavior of Mercury During Mild Pyrolysis of Coals and Nitric Acid-treated Coals 显示文摘 | Akira Ohki Kota Sagayarna Shomei Tanamachi | 2008 | Powder Technology2008，，180： | 1 |
| 6 | Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration显示文摘 | Hideaki Kitoh Shomei Ryozawa Tomohiko Harada Satoshi Kondoh Tomoko Furuya Shigeto Kawauchi Atsunori Oga Kiwamu Okita Kohsuke Sasaki | 2005 | Journal of Gastroenterology2005，，5： | 1 |
| 7 | Proteomics finding heat shock protein 27 as a biomarker for resistanceof pancreatic cancer cells to gemcitabine显示文摘 | Sayaka Mori-Iwamoto Yasuhiro Kuramitsu Shomei Ryozawa Kuniko Mikuria Masanori Fujimoto Shin-Ichiro Maehara Yoshihiro Maehara Kiwamu Okita Kazuyuki Nakamura Isao Sakaida | 2007 | International Journal of Oncology2007，，6： | 1 |
| 8 | Expression of glycolytic enzymes is increased in pancreatic canceroustissues as evidenced by proteomic profiling by two-dimensional electrophoresisand liquid chromatography-mass spectrometry/mass spectrometry显示文摘 | Kuniko Mikuriya Yasuhiro Kuramitsu Shomei Ryozawa Masanori Fujimoto Sayaka Mori Masaaki Oka Kimikazu Hamano Kiwamu Okita Isao Sakaida Kazuyuki Nakamura | 2007 | International Journal of Oncology2007，，4： | 1 |
| 9 | Vascular endothelial growth factor-C expression in human gallbladdercancer and its relationship to lymph node metastasis显示文摘 | Tetsuya Nakashima Satoshi Kondoh Hideaki Kitoh Hirokazu Ozawa Satoshi Okita Tomohiko Harada Kei Shiraishi Shomei Ryozawa Kiwamu Okita | 2003 | International Journal of Molecular Medicine2003，，1： | 1 |
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