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| 1 | Coordinated flight control of miniature fixed-wing UAV swarms: methods and experiments显示文摘In this paper,we present our recent advances in both theoretical methods and field experiments for the coordinated control of miniature fixed-wing unmanned aerial vehicle(UAV)swarms.We propose a multi-layered group-based architecture,which is modularized,mission-oriented,and can implement large-scale swarms.To accomplish the desired coordinated formation flight,we present a novel distributed coordinated-control scheme comprising a consensus-based circling rendezvous,a coordinated path-following control for the leader UAVs,and a leader-follower coordinated control for the follower UAVs.The current framework embeds a formation pattern reconfiguration technique.Moreover,we discuss two security solutions(inter-UAV collision avoidance and obstacle avoidance)in the swarm flight problem.The effectiveness of the proposed coordinated control methods was demonstrated in field experiments by deploying up to 21 fixed-wing UAVs. | Xiangke WANG Lincheng SHEN Zhihong LIU Shulong ZHAO Yirui CONG Zhongkui LI Shengde JIA Hao CHEN Yangguan YU Yuan CHANG Yajing WANG | 2019 | Science China(Information Sciences)2019，62，11： | 21 |
| 2 | Reconstruction of hydrological changes based on tree-ring data of the Haba River, northwestern China显示文摘Reconstructing the hydrological change based on dendrohydrological data has important implications for understanding the dynamic distribution and evolution pattern of a given river. The widespread, long-living coniferous forests on the Altay Mountains provide a good example for carrying out the dendrohydrological studies. In this study, a regional composite tree-ring width chronology developed by Larix sibirica Ledeb. and Picea obovata Ledeb. was used to reconstruct a 301-year annual(from preceding July to succeeding June) streamflow for the Haba River, which originates in the southern Altay Mountains, Xinjiang, China. Results indicated that the reconstructed streamflow series and the observations were fitting well, and explained 47.5% of the variation in the observed streamflow of 1957–2008. Moreover, floods and droughts in 1949–2000 were precisely captured by the streamflow reconstruction. Based on the frequencies of the wettest/driest years and decades, we identified the 19 th century as the century with the largest occurrence of hydrological fluctuations for the last 300 years. After applying a 21-year moving average, we found five wet(1724–1758, 1780–1810, 1822–1853, 1931–1967, and 1986–2004) and four dry(1759–1779, 1811–1821, 1854–1930, and 1968–1985) periods in the streamflow reconstruction. Furthermore, four periods(1770–1796, 1816–1836, 1884–1949, and 1973–1997) identified by the streamflow series had an obvious increasing trend. The increasing trend of streamflow since the 1970s was the biggest in the last 300 years and coincided with the recent warming-wetting trend in northwestern China. A significant correlation between streamflow and precipitation in the Altay Mountains indicated that the streamflow reconstruction contained not only local, but also broad-scale, hydro-climatic signals. The 24-year, 12-year, and 2.2–4.5-year cycles of the reconstruction revealed that the streamflow variability of the Haba River may be influenced by solar activity and the atmosphere–ocean system. | zhang tongwen yuan yujiang chen feng yu shulong zhang ruibo qin li jiang shengxia | 2018 | Journal of Arid Land2018，10，1： | 8 |
| 3 | The chemistry of heavy haze over Urumqi, Central Asia显示文摘 | Juan Li Guoshun Zhuang Kan Huang Yanfen Lin Qiongzhen Wang Yuhong Guo Jinghua Guo Shulong Yu Caixia Cui Joshua S. Fu | 2008 | Journal of Atmospheric Chemistry2008，，1： | 2 |
| 4 | Characteristics and sources of air-borne particulate in Urumqi, China, the upstream area of Asia dust显示文摘 | Juan Li Guoshun Zhuang Kan Huang Yanfen Lin Chang Xu Shulong Yu | 2007 | Atmospheric Environment2007，，4： | 2 |
| 5 | Tree‐ring‐based annual precipitation reconstruction for the H exi C orridor, NW C hina: consequences for climate history on and beyond the mid‐latitude A sian continent显示文摘 | Feng Chen Yujiang Yuan Wenshou Wei Ruibo Zhang Shulong Yu Huaming Shang Tongwen Zhang Li Qin Huiqing Wang Fahu Chen | 2013 | Boreas2013，，4： | 1 |
| 6 | Doppler Ultrasound-guided Percutaneous Nephrolithotomy With Two-step Tract Dilation for Management of Complex Renal Stones显示文摘 | Youming Xu Zhonghua Wu Jianhua Yu Shulong Wang Fang Li Jiushun Chen Jin Liu Kan Chen | 2012 | Urology2012，，： | 1 |
| 7 | The chemistry of heavy haze over Urumqi, Central Asia显示文摘 | Juan Li Guoshun Zhuang Kan Huang Yanfen Lin Qiongzhen Wang Yuhong Guo Jinghua Guo Shulong Yu Caixia Cui Joshua S. Fu | 2008 | Journal of Atmospheric Chemistry2008，，1： | 1 |
| 8 | A 602-year Reconstruction of July-June Streamflow in the Kuqa River, China, Reveals the Changing Hydrological Signals of the Tarim Basin显示文摘A regional tree-ring width chronology of Schrenk spruce(Picea schrenkiana) was used to determine the annual(previous July to current June) streamflow of the Kuqa River in Xinjiang, China, for the period of 1414–2015. A linear transformation of the tree-ring data accounted for 63.9% of the total variance when regressed against instrumental streamflow during 1957–2006. The model was validated by comparing the regression estimates against independent data. High streamflow periods with a streamflow above the 602-year mean occurred from 1430–1442, 1466–1492, 1557–1586, 1603–1615, 1687–1717, 1748–1767, 1795–1819, 1834–1856, 1888–1910 and 1989–2015. Low streamflow periods(streamflow below the mean) occurred from 1419–1429, 1443–1465, 1493–1556, 1587–1602, 1616–1686, 1720–1747, 1768–1794, 1820–1833, 1857–1887 and 1911–1988. The reconstruction compares well with the tree-ring-based streamflow series of the Tizinafu River from the Kunlun Mountains;both show well-known severe drought events. The streamflow reconstruction also shows highly synchronous upward trends since the 1980 s, suggesting that streamflow is related to Central Asian warming and humidification. Thus, the influences of the extremes and the persistence of low streamflows on local society may be considerable. Climatic changes in the watershed may be responsible for the change in the hydrologic regime of the Tarim Basin observed during the late twentieth century. | SHANG Huaming CHEN Feng WEI Wenshou MAO Weiyi ZHANG Ruibo ZHANG Tongwen YU Shulong | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 0 |
| 9 | Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer显示文摘Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric cancer.However,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal measure.Existing researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively lacking.This study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these patients.Methods:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome sequencing.Bioinformatics were used to analyze cell subtypes,metabolic pathways,and molecular signaling pathways.Changes in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)analyses.Finally,a multi-scale agent-based model(ABM)was constructed.The effects of combination treatment were further validated in nude mice to verify these effects predicted by the ABM.Results:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly overexpressed.Meanwhile,tumor-derived GLS1 microvesicles drove M2macrophage polarization.Furthermore,angiogenesis promoted trastuzumab resistance.IHC showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and nudemice.Mechanistically,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and in vivo experiments,we confirmed that the combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy had the best effect in reversing trastuzumab resistance in HER2-positive gastric cancer.Conclusions:This study revealed that tumor cells secrete GLS1 microvesicles via CDC42 to promote glutamine metabolism,M2 macrophage polarization,and pro-angiogenic function of macrophages,leading to acquired trastuzumab resistance in HER2-positive gastric cancer.A combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy may provide a new insight into reversing trastuzumab resistance. | Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing Wu Qiong Huang Le Yu Fenghua Wang Min Shi | 2023 | Cancer Communications2023，43，8： | 0 |
| 10 | Climatic response of Pinus sylvestris var. mongolica tree-ring width and precipitation reconstruction for the northern Greater Higgnan Mountains, China, since 1720显示文摘August–June precipitation has been reconstructed back to AD 1720 for the northern Greater Higgnan Mountains, China, by use of Pinus sylvestris var. mongolica tree-ring width. The reconstruction explains the variance of 39% in observed precipitation from 1973 to 2008. Some extremely dry/wet signals in historical documents and other precipitation reconstructions in previous studies are precisely captured in our reconstruction. Wet periods occurred during the periods of 1730 to 1746, 1789 to 1812, 1844 to 1903, 1920 to 1930, 1942 to 1961, and 1985 to 1998; while periods of 1747 to 1788, 1813 to 1843, 1904 to 1919, 1931 to 1941, and 1962 to 1984 were relatively dry. Power spectral and wavelet analyses demonstrated the existence of significant 24-year, 12-year, and 2-year cycles of variability. | TongWen Zhang YuJiang Yuan WenShou Wei RuiBo Zhang ShuLong Yu Feng Chen HuaMing Shang Li Qin ZiAng Fan | 2014 | Research in Cold and Arid Regions2014，6，6： | 0 |
| 11 | Magma Chamber Process of Post-collisional Magmatism: Insight from Textural and Elemental Characteristics of Plagioclase from the Tatun Volcanic Group, Northern Taiwan Volcanic Zone显示文摘The Taiwan mountain belt, one of the youngest orogenies in the world, is caused by the collision of the Luzon arc with the Eurasian margin, which leads to post-collisional extension and magmatism in the Northern Taiwan Volcanic Zone(NTVZ). The magma chamber process in this region has not previously been elucidated in detail. In this paper, the textural and compositional features of plagioclase phenocrysts in basalt from the Tatun Volcanic Group(TTVG) were studied to restrict the dynamics of magma system. Results show that the magma melts in TTVG are mainly sourced from the underlying MORB-like mantle wedge but influenced by incorporation of subduction components, causing the elevated Sr/Y and Ba/Y ratios in magma melts. The subduction components are mainly transported in the form of sediment melt. The plagioclase phenocrysts in the TTVG volcanic rocks are generally coarsely core-sieved with a clear rim. The An contents in the rims of plagioclase are much lower than those of cores, and elevated FeO concentrations are detected in the plagioclase rims. We propose there exists a double-layer magma chamber in this region. The core of the plagioclase was crystalized in the deeper quiescent magma chamber(~21 km), which was subsequently partially dissolved during the ascent of magma melt under H_(2)O-undersaturated condition, forming the typical coarsely sieved texture and synneusis. When this crystal-rich melt migrates into the shallower chamber, water saturation is reached and more sodic plagioclase formed as the rim of phenocryst. Due to the considerably higher fO_(2) in the shallow chamber than in the deeper one, and the distribution of Fe between plagioclase and melt positively correlates with fO_(2), the FeO content in the plagioclase rim elevates in conjunction with increasing fO_(2). | ZHANG Xia GUO Kun ZHANG Yu LAI Zhiqing JIANG Shulong JIANG Wenpeng LI Jingbo | 2022 | Acta Geologica Sinica(English Edition)2022，96，5： | 0 |
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