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| 1 | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells显示文摘橡黄素是自然地发生之一饮食的黄酮醇混合物。它在植物富有地是在场的并且有 chemopreventive 和 anticancer 效果。调查它的 anticancer 机制,我们对尖锐白血病房间线检验了橡黄素的活动, HL-60。我们的结果证明橡黄素禁止了房间增长并且在一个时间依赖者和剂量依赖者举止导致了 apoptosis。而且,橡黄素下面调整 anti-apoptosis 蛋白质 Bcl-2 的表示并且起来调整 pro-apoptosis 蛋白质 Bax 的表示。Caspase-3 被橡黄素也激活,它开始了一条 caspase-3-depended mitochodrial 小径导致 apoptosis。橡黄素禁止了 cycloocygenase-2 (Cox-2 ) 的表示,这也被发现 mRNA 和 Cox-2 蛋白质。一起拿,这些调查结果建议橡黄素由禁止 Cox-2 表示在一条 caspase-3-dependent 小径导致 apoptosis 并且调整下游的 apoptotic 部件的表示,包括 Bcl-2 和 Bax。橡黄素能是可能安全地在白血病治疗被使用的一个有势力和有希望的药。 | Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 28 |
| 2 | SKP2 siRNA inhibits the degradation of P27^kip1 and down-regulates the expression of MRP in HL-60/A cells显示文摘S 阶段联系 kinase 的蛋白质 2 (SKP2 ) 基因是肿瘤 suppressor 基因,并且涉及 P27kip1 的调停 ubiquitin 的降级。SKP2 和 P27kip1 影响通过调整白血病房间的增长, apoptosis 和区别继续和白血病的预后。在这研究,我们探索了通过 SKP2 下面规定 HL-60/A 药抵抗逆行的机制。HL-60/A 房间是由有 SKP2 siRNA 的 Amaxa Nucleofector 系统的 nucleofected。Skp2, P27kip1,和多药抵抗的基因和蛋白质表示层次联系了蛋白质(MRP ) 被反向的抄写聚合酶链反应和西方的污点分析分别地决定。房间周期被流动 cytometry 分析。50% 禁止的集中价值在 chemotherapeutics 的不同集中下面根据这些二种房间的死亡率用细胞毒素的分析被计算比较房间的敏感。HL-60/A 房间显示出由抗力移转特征的多药抵抗显型到 adriamycin, daunorubicin,和 arabinosylcytosine,由于 MRP 的表示。我们发现 SKP2 的表示比在 HL-60 房间在 HL-60/A 房间是更高的,但是 P27kip1 的表示更低。而 P27kip1 的蛋白质水平是起来调整的,在由 SKP2 siRNA 的 HL-60/A 房间 nucleofected 的 SKP2 的表示是下面调整的。与在控制组(由控制 siRNA 的 nucleofected ) 的 MRP 表达式水平相比, mRNA 和蛋白质表达式由 SKP2 siRNA 在 HL-60/A 房间 nucleofected MRP 铺平更低,并且后者房间对 adriamycin, daunorubicin,和 arabinosylcytosine 更敏感。下面调整在 G0/G1 阶段的 SKP2 表示和逮捕房间与下面调整的 MRP 改进白血病房间的药敏感表示。 | Jie Xiao Songmei Yin Yiqing Li Shuangfeng Xie Danian Nie Liping Ma Xiuju Wang Yudan Wu Jianhong Feng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 7 |
| 3 | Preparation and phase change performance of Na_2HPO_4·12H_2O@poly(lactic acid) capsules for thermal energy storage显示文摘Micro-encapsulated phase-change materials(micro PCMs) with Na_2 HPO_4·12 H_2 O encapsulated in poly(lactic acid)(PLA) shell were prepared by a solvent evaporation–precipitation method that involves the use of a coaxial needle. The effects of PLA concentration, stirring speed, injection rate of core and shell solutions, and polyvinyl alcohol(PVA) concentration on phase change properties were investigated. The thermal properties of microP CMs were characterized by differential scanning calorimetry(DSC). The capsules prepared under the optimal conditions are about 2 mm in diameter and show a latent heat of up to 122.2 J·g^(-1). | Na Fan Lang Chen Guoyong Xie Donghong Yin Chak-Tong Au Shuangfeng Yin | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 4 |
| 4 | The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells显示文摘我们的以前的研究证明了橡黄素禁止 Cox-2 和 Bcl-2 表情,并且导致人的白血病 HL-60 cellapoptosis。以便在 HL-60cells 的导致橡黄素的 apoptosis 上调查激活安培的蛋白质 kinase (AMPK ) 的角色,我们使用了流动 cytometry 检测房间 apoptosis。LKB1, phosphorylated AMPK (p-AMPK ) ,和 Cox-2 proteinwere 的表情由西方的污点在 HL-60 房间和正常的外部血 mononuclear 房间(PBMC ) 检测了。LKB1, p-AMPK,和 Cox-2 的表情与橡黄素在文化以后在 HL-60 房间被检测。p-AMPK 的表情与 AMPK 禁止者混合物 C 在文化以后在 HL-60cells 被检测。然后, LKB1, p-AMPK,和 Cox-2 的表情与独自一个的橡黄素或橡黄素 + 混合物 C 在文化以后在 HL-60cells 被检测。在 PBMC 和 HL-60 之间没有重要 differencein LKB1,这被发现。在 PBMC 的 p-AMPK 在 HL-60 比那高,当 Cox-2 更低时。在 HL-60with 橡黄素的文化以后, p-AMPK 被增加, Cox-2 被减少,但是 LKB1 仍然保持未改变。在有 CompoundC 的 HL-60 的文化以后, p-AMPK 被减少。在 LKB1 在之间没有重要差别橡黄素独自一个并且橡黄素 + CompoundC 组。p-AMPK 更显著地减少了,当 Cox-2 在橡黄素 + 混合物 C groupsthan 更显著地增加了时那些在橡黄素独自一个的组。一起拿,这些调查结果建议橡黄素激活独立于 LKB1 激活的 AMPK expressionin HL-60 房间,由激活 AMPK 禁止 Cox-2 表示,并且进一步调整施加它的反白血病效果的 apoptosis 的 Bcl-2-dependentpathways。 | Jie Xiao Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 2 |
| 5 | Involvement of levels of Toll like receptor-4 in monocytes, CD4+ T-lymphocyte subsets, and cytokines in patients with immune thrombocytopenic purpura显示文摘 | Hongyun Liu Xianfeng Ouyang Yiqing Li Hua Zeng Xiuju Wang Shuangfeng Xie Danian Nie Jie Xiao Jing Wei Yudan Wu Songmei Yin Liping Ma | 2013 | Thrombosis Research2013，，： | 2 |
| 6 | Bismuth subnitrate as an efficient heterogeneous catalyst for acetalization and ketalization of carbonyl compounds with diols显示文摘 | WU Shuisheng DAI Weili YIN Shuangfeng | 2008 | Catalysis2008，124，12： | 1 |
| 7 | Green and efficient cycloaddition of CO2 toward epoxides over thiamine derivatives/GO aerogels under mild and solvent-free conditions显示文摘Thiamine derivatives that are cheap, readily available, non-toxic and green are used as heterogeneous catalyst for the generation of cyclic carbonates through cycloaddition of CO_2 to epoxides without the need of co-catalyst and solvent. The interaction between thiamine hydrochloride(VB_1-Cl) and substrates(CO_2 and propylene oxide) was proven by ultraviolet-visible spectroscopy and ~1H nuclear magnetic resonance analysis, and it is deduced that the synergistic action among multi-functional groups(hydroxyl, halide anion and amine) is a favorable factor for cycloaddition reaction. A series of VB_1/GO aerogels were facilely prepared through the addition of aqueous VB_1 derivatives to a suspension of GO in ethanol at room temperature. It was found that the aerogel generated through the interaction of VB_1-Cl with GO shows catalytic activity and stability higher than those of VB_1-Cl. It is because the electrostatic interaction between GO and VB_1-Cl enhances the nucleophilicity and leaving ability of anion. The effects of reaction temperature, catalyst loading, CO_2 pressure and reaction time on CO_2 cycloaddition to propylene oxide were thoroughly studied. | Ziqi Yi Donghui Lan Ying Wang Lang Chen Chaktong Au Shuangfeng Yin | 2017 | Science China Chemistry2017，60，7： | 1 |
| 8 | A mini review on chemical fixation of CO_(2):Absorption and catalytic conversion into cyclic carbonates显示文摘In this article,we present our research results on chemical fixation of CO_(2) using organobismuth compounds.We fabricated bismuth biphenoate complex,Zn-Mg-Al composite oxides,and SBA-15 or Al-SBA-15 immobilized hydroxyl ionic liquid for CO_(2) cycloaddition onto epoxides.The hypervalent bismuth compounds show good ability for association and dissociation with CO_(2).The bismuth biphenolate complexes are catalytically effective for the cycloaddition reaction.The heterogeneous catalysts,viz.Zn-Mg-Al oxides and SBA-15 or Al-SBA-15 immobilized ionic liquid,are efficient for the synthesis of cyclic carbonate from CO_(2) and epoxide.It is found that the presence of a trace amount of water can improve the catalytic activity of the immobilized ionic liquid. | Weili DAI Shenglian LUO Shuangfeng YIN Chaktong AU | 2010 | Frontiers of Chemical Science and Engineering2010，4，2： | 1 |
| 9 | 3-(2-hydrox- yl-Ethyl)-1-propylimidazolium bromide immobilized on SBA- 15 as efficient catalyst for the synthesis of cyclic carbonates via the coupling of carbon dioxide with epoxides显示文摘 | Dai Weili Chen Lang Yin Shuangfeng | 2010 | Catal Lett2010，135，： | 1 |
| 10 | Facile synthesis of BiOC1 nano-flowers of narrow band gap and their visible- light-induced photocatalytic property 显示文摘 | Chen Lang Yin Shuangfeng Huang Rui | 2012 | Catalysis Commu- nications2012，23，： | 1 |
| 11 | Nanosized Ru on high-surface-area superbasic ZrO2-KOH for efficient generation of hydrogen via ammonia decomposition 显示文摘 | Yin Shuangfeng Xu Boqing Wang Shuiju | 2006 | Applied Catalysis A2006，301，： | 1 |
| 12 | Graphite as a highly efficient and stable catalyst for the production of lactones 显示文摘 | LI Yuefang GUO Mingqi YIN Shuangfeng | 2013 | Carbon2013，55，： | 1 |
| 13 | Preparation of nanosized silicalite-1 and its application in vapor-phase Beckmann rearrangement of cyclohexanone oxime显示文摘 | Deng Yiqiang Yin Shuangfeng Au Chaktong | 2012 | Ind Eng Chem Res2012，51，28： | 1 |
| 14 | Methane oxybromination over Rh-based catalysts:Effect of supports显示文摘Bromine mediation has been regarded as one of the most efficient ways to activate and convert methane to useful organics.This article reports the effects of active components(Rh,Ru,Pd and Pt)and supports(SiO2,Mg O and Al2O3)on the catalysis of methane oxybromination.Among the prepared catalysts,Rh/SiO2 is the best in performance(CH4 conversion of ca.20%and CH3Br selectivity exceeding 70%).The results reveal that support type has a notable influence on the catalytic performance of Rh,especially on product distribution.The high selectivity to CH3 Br over Rh/SiO2 is attributed to its low propensity for CH3Br oxidation.It was found that Rh small in particle size shows high catalytic activity and CH3Br selectivity.Although silicalite-1 zeolite suffers from a certain degree of structural damage due to the presence of high temperature steam,the use of silicalite-1 as support results in a performance comparable to that of Rh/SiO2. | Peng Wang Lang Chen Sheng Shen Chak-Tong Au Shuangfeng Yin | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 1 |
| 15 | Facile Syn- thesis of BiOCI Nano-Flowers of Narrow Band Gap and Their Visible-Light-Induced Photocatalytie Property 显示文摘 | Chen Lang Yin Shuangfeng Huang Rui | 2012 | Catal Com- mun2012，23，： | 1 |
| 16 | Preparation of nanosized silicalite-1 and its application in vapor-phase Beckmann rearrangement of cyclohexanone oxime显示文摘 | Deng Yiqiang Yin Shuangfeng Au Chaktong | 2012 | Ind Eng Chem Res2012，51，28： | 1 |
| 17 | Dual-template synthesis of HZSM-5 zeolites with tailored activity in toluene methylation with CH3Br显示文摘Shape-selective zeolites(UZ-x/y) were synthesized by a one-pot method using TPAOH(y) and/or MeEt3 N^+I^-(x) as templates.The use of MeEt3 N^+I^- affects the crystal growth and the distribution of acid sites on the external surface of the zeolites.The catalysts show excellent catalytic activity towards toluene alkylation with CH3 Br.With toluene conversion of 36.3% and p-xylene selectivity of 66.2%,HZ-40/0 is the most effective among the prepared catalysts,showing a p-xylene yield of 21.2%.The improved para-selectivity is mainly due to the decrease of acid sites on the external surface of the catalysts. | Wuhui Wang Jun Xie Peng Wang Lang Chen Chaktong Au Shuangfeng Yin | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 0 |
| 18 | Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway显示文摘Acute myeloid leukemia(AML)is one of the most common malignancies of the hematopoietic progenitor cell in adults.Quercetin has gained recognition over the years because of its anti-cancer effect with minimal toxicity.Herein,we aim to investigate the anti-leukemia mechanism of quercetin and to decipher the signaling pathway of quercetin in HL-60 leukemic cells.We observed that quercetin induces apoptosis and autophagic cell death,in which both pathways play an important role in suppressing the viability of leukemia cells.Phosphorylated AMPK(p-AMPK)protein expressions are lower in primary AML cells,HL-60 cells,KG-1 and THP-1 cells than in peripheral blood monocular cells.After quercetin treatment,the expression of p-AMPK is increased while the expression of pmTOR is decreased in a dose-dependent manner.Mechanistically,compound C,an AMPK phosphorylation inhibitor,upregulates the phosphorylation of mTOR and inhibits autophagy and apoptosis in quercetin-induced HL-60 cells,while silencing of CaMKKβinhibits the quercetin-induced phosphorylation of AMPK,resulting in increased mTOR phosphorylation.Furthermore,silencing of CaMKKβinhibits the autophagy in HL-60 cells.Taken together,our data delineate that quercetin plays its anti-leukemia role by inhibiting cell viability and inducing apoptosis and autophagy in leukemia cells.Quercetin inhibits the phosphorylation of mTOR by regulating the activity of AMPK,thus playing a role in the regulation of autophagy and apoptosis.CaMKKβis a potential upstream molecule for AMPK/mTOR signaling pathway,through which quercetin induces autophagy in HL-60 cells. | Jie Xiao Ben Zhang Songmei Yin Shuangfeng Xie Kezhi Huang Jieyu Wang Wenjuan Yang Hongyun Liu Guoyang Zhang Xiaoyan Liu Yiqing Li Danian Nie | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 19 | Cationic organobismuth complex as an effective catalyst for conversion of CO_(2) into cyclic carbonates显示文摘In order to achieve high-efficiency conversion of CO_(2) into valuable chemicals,and to exploit new applications of organobismuth compounds,cationic organobismuth complex with 5,6,7,12-tetrahydrodibenz[c,f][1,5]azabismocine framework was examined for the first time for the coupling of CO_(2) into cyclic carbonates,using terminal epoxides as substrates and tetrabutylammonium halide as co-catalyst in a solvent-free environment under mild conditions.It is shown that the catalyst exhibited high activity and selectivity for the coupling reaction of CO_(2) with a wide range of terminal epoxide.The selectivity of propylene carbonates could reach 100%,and the maximum turnover frequency was up to 10740 h^(-1) at 120℃ and 3 MPa CO_(2) pressure when tetrabutylammonium iodide was used as co-catalyst.Moreover,the catalyst is environment friendly,resistant to air and water,and can be readily reused and recycled without any loss of activity,demonstrating a potential in industrial application. | Xiaowen ZHANG Weili DAI Shuangfeng YIN Shenglian LUO Chak-Tong AU | 2009 | Frontiers of Environmental Science & Engineering2009，3，1： | 0 |
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